Heterogeneity of prostate-specific membrane antigen (PSMA) and PSMA-ligand uptake detection combining autoradiography and postoperative pathology in primary prostate cancer

Heterogeneity of prostate-specific membrane antigen (PSMA) and PSMA-ligand uptake detection combining autoradiography and postoperative pathology in primary prostate cancer

Abstract Background Targeting prostate-specific membrane antigen (PSMA) has been highly successful for imaging and treatment of prostate cancer. However, heterogeneity in immunohistochemistry indicates limitations in the effect of imaging and radionuclide therapy of multifocal disease. 99mTc-PSMA-I&...

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Bibliographic Details
Main Authors: Hui Wang, Marianne Remke, Thomas Horn, Kristina Schwamborn, Yiyao Chen, Katja Steiger, Wilko Weichert, Hans-Jürgen Wester, Margret Schottelius, Wolfgang A. Weber, Matthias Eiber
Format: Article
Language:English
Published: SpringerOpen 2023-11-01
Series:EJNMMI Research
Subjects:
Primary prostate cancer
Heterogeneity
99mTc-PSMA-I&S
ARG
Immunohistochemistry
Online Access:https://doi.org/10.1186/s13550-023-01044-8

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