Characterization of muscle mass, strength and mobility of critically ill patients with SARS-CoV-2 pneumonia: Distribution by sex, age, days on mechanical ventilation, and muscle weakness
Objective: Quantify and categorize by sex, age, and time spent on mechanical ventilation (MV), the decline in skeletal muscle mass, strength and mobility in critically ill patients infected with SARS-CoV-2 and requiring mechanical ventilation while at intensive care unit (ICU).Design: Prospective ob...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1095228/full |
| _version_ | 1811167271396048896 |
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| author | Alexis Silva-Gutiérrez Macarena Artigas-Arias Macarena Artigas-Arias Andrea Alegría-Molina Pablo Guerra-Vega Pablo Navarrete Ángela Venegas Carlos Montecinos Lorena Vásquez Karen Moraga César Rubilar Germán Villagrán Rodrigo Parada Kaio Fernando Vitzel Gabriel Nasri Marzuca-Nassr |
| author_facet | Alexis Silva-Gutiérrez Macarena Artigas-Arias Macarena Artigas-Arias Andrea Alegría-Molina Pablo Guerra-Vega Pablo Navarrete Ángela Venegas Carlos Montecinos Lorena Vásquez Karen Moraga César Rubilar Germán Villagrán Rodrigo Parada Kaio Fernando Vitzel Gabriel Nasri Marzuca-Nassr |
| author_sort | Alexis Silva-Gutiérrez |
| collection | DOAJ |
| description | Objective: Quantify and categorize by sex, age, and time spent on mechanical ventilation (MV), the decline in skeletal muscle mass, strength and mobility in critically ill patients infected with SARS-CoV-2 and requiring mechanical ventilation while at intensive care unit (ICU).Design: Prospective observational study including participants recruited between June 2020 and February 2021 at Hospital Clínico Herminda Martin (HCHM), Chillán, Chile. The thickness of the quadriceps muscle was evaluated by ultrasonography (US) at intensive care unit admission and awakening. Muscle strength and mobility were assessed, respectively, through the Medical Research Council Sum Score (MRC-SS) and the Functional Status Score for the Intensive Care Unit Scale (FSS-ICU) both at awakening and at ICU discharge. Results were categorized by sex (female or male), age (<60 years old or ≥60 years old) and time spent on MV (≤10 days or >10 days).Setting: Intensive care unit in a public hospital.Participants: 132 participants aged 18 years old or above (women n = 49, 60 ± 13 years; men n = 85, 59 ± 12 years) admitted to intensive care unit with a confirmed diagnosis of severe SARS-CoV-2 and requiring MV for more than 48 h were included in the study. Patients with previous physical and or cognitive disorders were excluded.Interventions: Not applicable.Results: Muscle thickness have significantly decreased during intensive care unit stay, vastus intermedius (−11%; p = 0.025), rectus femoris (−20%; p < 0.001) and total quadriceps (−16%; p < 0.001). Muscle strength and mobility were improved at intensive care unit discharge when compared with measurements at awakening in intensive care unit (time effect, p < 0.001). Patients ≥60 years old or on MV for >10 days presented greater muscle loss, alongside with lower muscle strength and mobility.Conclusion: Critically ill patients infected with SARS-CoV-2 and requiring MV presented decreased muscle mass, strength, and mobility during their intensive care unit stay. Factors associated with muscle mass, such as age >60 years and >10 days of MV, exacerbated the critical condition and impaired recovery. |
| first_indexed | 2024-04-10T16:06:32Z |
| format | Article |
| id | doaj.art-e735518bdc8b409297a30afe317301b5 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-10T16:06:32Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-e735518bdc8b409297a30afe317301b52023-02-10T04:40:35ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-02-011410.3389/fphys.2023.10952281095228Characterization of muscle mass, strength and mobility of critically ill patients with SARS-CoV-2 pneumonia: Distribution by sex, age, days on mechanical ventilation, and muscle weaknessAlexis Silva-Gutiérrez0Macarena Artigas-Arias1Macarena Artigas-Arias2Andrea Alegría-Molina3Pablo Guerra-Vega4Pablo Navarrete5Ángela Venegas6Carlos Montecinos7Lorena Vásquez8Karen Moraga9César Rubilar10Germán Villagrán11Rodrigo Parada12Kaio Fernando Vitzel13Gabriel Nasri Marzuca-Nassr14Unidad de Paciente Crítico Adulto, Hospital Clínico Herminda Martín, Chillán, ChileDoctorado en Ciencias mención Biología Celular y Molecular Aplicada, Universidad de La Frontera, Temuco, ChileDepartamento de Procesos Terapéuticos, Facultad de Ciencias de la Salud, Universidad Católica de Temuco, Temuco, ChileMagíster en Terapia Física con mención, Facultad de Medicina, Universidad de La Frontera, Temuco, ChileUnidad de Paciente Crítico Adulto, Clínica Alemana, Osorno, ChileUnidad de Paciente Crítico Adulto, Hospital Clínico Herminda Martín, Chillán, ChileUnidad de Paciente Crítico Adulto, Hospital Clínico Herminda Martín, Chillán, ChileUnidad de Paciente Crítico Adulto, Hospital Clínico Herminda Martín, Chillán, ChileUnidad de Paciente Crítico Adulto, Hospital Clínico Herminda Martín, Chillán, ChileUnidad de Paciente Crítico Adulto, Hospital Clínico Herminda Martín, Chillán, ChileUnidad de Paciente Crítico Adulto, Hospital Clínico Herminda Martín, Chillán, ChileUnidad de Paciente Crítico Adulto, Hospital Clínico Herminda Martín, Chillán, ChileUnidad de Paciente Crítico Adulto, Hospital Clínico Herminda Martín, Chillán, ChileSchool of Health Sciences, College of Health, Massey University, Auckland, New ZealandDepartamento de Ciencias de la Rehabilitación, Facultad de Medicina, Universidad de La Frontera, Temuco, ChileObjective: Quantify and categorize by sex, age, and time spent on mechanical ventilation (MV), the decline in skeletal muscle mass, strength and mobility in critically ill patients infected with SARS-CoV-2 and requiring mechanical ventilation while at intensive care unit (ICU).Design: Prospective observational study including participants recruited between June 2020 and February 2021 at Hospital Clínico Herminda Martin (HCHM), Chillán, Chile. The thickness of the quadriceps muscle was evaluated by ultrasonography (US) at intensive care unit admission and awakening. Muscle strength and mobility were assessed, respectively, through the Medical Research Council Sum Score (MRC-SS) and the Functional Status Score for the Intensive Care Unit Scale (FSS-ICU) both at awakening and at ICU discharge. Results were categorized by sex (female or male), age (<60 years old or ≥60 years old) and time spent on MV (≤10 days or >10 days).Setting: Intensive care unit in a public hospital.Participants: 132 participants aged 18 years old or above (women n = 49, 60 ± 13 years; men n = 85, 59 ± 12 years) admitted to intensive care unit with a confirmed diagnosis of severe SARS-CoV-2 and requiring MV for more than 48 h were included in the study. Patients with previous physical and or cognitive disorders were excluded.Interventions: Not applicable.Results: Muscle thickness have significantly decreased during intensive care unit stay, vastus intermedius (−11%; p = 0.025), rectus femoris (−20%; p < 0.001) and total quadriceps (−16%; p < 0.001). Muscle strength and mobility were improved at intensive care unit discharge when compared with measurements at awakening in intensive care unit (time effect, p < 0.001). Patients ≥60 years old or on MV for >10 days presented greater muscle loss, alongside with lower muscle strength and mobility.Conclusion: Critically ill patients infected with SARS-CoV-2 and requiring MV presented decreased muscle mass, strength, and mobility during their intensive care unit stay. Factors associated with muscle mass, such as age >60 years and >10 days of MV, exacerbated the critical condition and impaired recovery.https://www.frontiersin.org/articles/10.3389/fphys.2023.1095228/fullCOVID-19muscle weaknesscritical caremuscular atrophyfunctional status |
| spellingShingle | Alexis Silva-Gutiérrez Macarena Artigas-Arias Macarena Artigas-Arias Andrea Alegría-Molina Pablo Guerra-Vega Pablo Navarrete Ángela Venegas Carlos Montecinos Lorena Vásquez Karen Moraga César Rubilar Germán Villagrán Rodrigo Parada Kaio Fernando Vitzel Gabriel Nasri Marzuca-Nassr Characterization of muscle mass, strength and mobility of critically ill patients with SARS-CoV-2 pneumonia: Distribution by sex, age, days on mechanical ventilation, and muscle weakness Frontiers in Physiology COVID-19 muscle weakness critical care muscular atrophy functional status |
| title | Characterization of muscle mass, strength and mobility of critically ill patients with SARS-CoV-2 pneumonia: Distribution by sex, age, days on mechanical ventilation, and muscle weakness |
| title_full | Characterization of muscle mass, strength and mobility of critically ill patients with SARS-CoV-2 pneumonia: Distribution by sex, age, days on mechanical ventilation, and muscle weakness |
| title_fullStr | Characterization of muscle mass, strength and mobility of critically ill patients with SARS-CoV-2 pneumonia: Distribution by sex, age, days on mechanical ventilation, and muscle weakness |
| title_full_unstemmed | Characterization of muscle mass, strength and mobility of critically ill patients with SARS-CoV-2 pneumonia: Distribution by sex, age, days on mechanical ventilation, and muscle weakness |
| title_short | Characterization of muscle mass, strength and mobility of critically ill patients with SARS-CoV-2 pneumonia: Distribution by sex, age, days on mechanical ventilation, and muscle weakness |
| title_sort | characterization of muscle mass strength and mobility of critically ill patients with sars cov 2 pneumonia distribution by sex age days on mechanical ventilation and muscle weakness |
| topic | COVID-19 muscle weakness critical care muscular atrophy functional status |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1095228/full |
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