Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control
Schistosomiasis is caused by the parasite Schistosoma mansoni, which uses mollusks of the Biomphalaria genus as intermediate hosts. In 2020, approximately 241 million people worldwide underwent treatment for schistosomiasis. For this reason, the World Health Organization encourages research on alter...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1078936/full |
| _version_ | 1797895443897647104 |
|---|---|
| author | Leonardo da Silva Rangel Leonardo da Silva Rangel Francisco Paiva Machado Francisco Paiva Machado Raquel Amaral Ana Cláudia Rodrigues Da Silva Ana Cláudia Rodrigues Da Silva Marcelo Guerra Santos José Augusto Albuquerque Dos Santos Natalia Lidmar Von Ranke Carlos Rangel Rodrigues Leandro Rocha Leandro Rocha Leandro Rocha Robson Xavier Faria Robson Xavier Faria |
| author_facet | Leonardo da Silva Rangel Leonardo da Silva Rangel Francisco Paiva Machado Francisco Paiva Machado Raquel Amaral Ana Cláudia Rodrigues Da Silva Ana Cláudia Rodrigues Da Silva Marcelo Guerra Santos José Augusto Albuquerque Dos Santos Natalia Lidmar Von Ranke Carlos Rangel Rodrigues Leandro Rocha Leandro Rocha Leandro Rocha Robson Xavier Faria Robson Xavier Faria |
| author_sort | Leonardo da Silva Rangel |
| collection | DOAJ |
| description | Schistosomiasis is caused by the parasite Schistosoma mansoni, which uses mollusks of the Biomphalaria genus as intermediate hosts. In 2020, approximately 241 million people worldwide underwent treatment for schistosomiasis. For this reason, the World Health Organization encourages research on alternative molluskicides based on plant species. The objective of this work was to investigate Neomitranthes obscura essential oil from leaf chemical composition and its essential oil nanoemulsion activity on intermediate hosts of schistosomiasis Biomphalaria glabrata control. The major chemical components of the Neomitranthes obscura essential oil were zonarene, seline-3,7(11)-diene, β-selinene, and α-selinene. The nanoemulsion tested using 24-well plate methodology showed lethality and juvenile mollusks with LC90 values of 53.9 and 25.0 ppm after 48 h, respectively, and on their spawning with an LC90 of 66.2 ppm after 48 h. Additionally, the nanoemulsion exhibited an LC90 value against the infective form of the parasite Schistosoma mansoni of 11.5 ppm after 4 h. This pharmaceutical formulation acted inhibiting the acetylcholinesterase activity and was not toxic for Mellanoides sp. This result suggests the use of this nanoformulation as a promising alternative in the control of Biomphalaria glabrata and the transmission of schistosomiasis. |
| first_indexed | 2024-04-10T07:25:39Z |
| format | Article |
| id | doaj.art-e7371655b60e44a49c4c458a457f98c3 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-10T07:25:39Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-e7371655b60e44a49c4c458a457f98c32023-02-24T07:38:16ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-02-011410.3389/fphar.2023.10789361078936Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis controlLeonardo da Silva Rangel0Leonardo da Silva Rangel1Francisco Paiva Machado2Francisco Paiva Machado3Raquel Amaral4Ana Cláudia Rodrigues Da Silva5Ana Cláudia Rodrigues Da Silva6Marcelo Guerra Santos7José Augusto Albuquerque Dos Santos8Natalia Lidmar Von Ranke9Carlos Rangel Rodrigues10Leandro Rocha11Leandro Rocha12Leandro Rocha13Robson Xavier Faria14Robson Xavier Faria15Laboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, BrazilPrograma de Pós Graduação em Ciências e Biotecnologia, Universidade Federal Fluminense, Niterói, RJ, BrazilLaboratório de Tecnologia de Produtos Naturais, Universidade Federal Fluminense, Niterói, RJ, BrazilPrograma de Pós Graduação em Biotecnologia Vegetal e Bioprocessos, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, BrazilDepartamento de Ciências, Faculdade de Formação de Professores, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, BrazilLaboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, BrazilPrograma de Pós Graduação em Ciências e Biotecnologia, Universidade Federal Fluminense, Niterói, RJ, BrazilDepartamento de Ciências Biológicas e da Saúde, Universidade Federal de Amapá, Macapá, AP, BrazilLaboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, BrazilCentro de Formação de Professores, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, BrazilCentro de Formação de Professores, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, BrazilPrograma de Pós Graduação em Ciências e Biotecnologia, Universidade Federal Fluminense, Niterói, RJ, BrazilLaboratório de Tecnologia de Produtos Naturais, Universidade Federal Fluminense, Niterói, RJ, BrazilPrograma de Pós Graduação em Biotecnologia Vegetal e Bioprocessos, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, BrazilLaboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, BrazilPrograma de Pós Graduação em Ciências e Biotecnologia, Universidade Federal Fluminense, Niterói, RJ, BrazilSchistosomiasis is caused by the parasite Schistosoma mansoni, which uses mollusks of the Biomphalaria genus as intermediate hosts. In 2020, approximately 241 million people worldwide underwent treatment for schistosomiasis. For this reason, the World Health Organization encourages research on alternative molluskicides based on plant species. The objective of this work was to investigate Neomitranthes obscura essential oil from leaf chemical composition and its essential oil nanoemulsion activity on intermediate hosts of schistosomiasis Biomphalaria glabrata control. The major chemical components of the Neomitranthes obscura essential oil were zonarene, seline-3,7(11)-diene, β-selinene, and α-selinene. The nanoemulsion tested using 24-well plate methodology showed lethality and juvenile mollusks with LC90 values of 53.9 and 25.0 ppm after 48 h, respectively, and on their spawning with an LC90 of 66.2 ppm after 48 h. Additionally, the nanoemulsion exhibited an LC90 value against the infective form of the parasite Schistosoma mansoni of 11.5 ppm after 4 h. This pharmaceutical formulation acted inhibiting the acetylcholinesterase activity and was not toxic for Mellanoides sp. This result suggests the use of this nanoformulation as a promising alternative in the control of Biomphalaria glabrata and the transmission of schistosomiasis.https://www.frontiersin.org/articles/10.3389/fphar.2023.1078936/fullessential oilNeomitranthes obscuramolluskicideBiomphalariaSchistosoma mansoni |
| spellingShingle | Leonardo da Silva Rangel Leonardo da Silva Rangel Francisco Paiva Machado Francisco Paiva Machado Raquel Amaral Ana Cláudia Rodrigues Da Silva Ana Cláudia Rodrigues Da Silva Marcelo Guerra Santos José Augusto Albuquerque Dos Santos Natalia Lidmar Von Ranke Carlos Rangel Rodrigues Leandro Rocha Leandro Rocha Leandro Rocha Robson Xavier Faria Robson Xavier Faria Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control Frontiers in Pharmacology essential oil Neomitranthes obscura molluskicide Biomphalaria Schistosoma mansoni |
| title | Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control |
| title_full | Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control |
| title_fullStr | Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control |
| title_full_unstemmed | Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control |
| title_short | Molluskicidal nanoemulsion of Neomitranthes obscura (DC.) N. Silveira for schistosomiasis control |
| title_sort | molluskicidal nanoemulsion of neomitranthes obscura dc n silveira for schistosomiasis control |
| topic | essential oil Neomitranthes obscura molluskicide Biomphalaria Schistosoma mansoni |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1078936/full |
| work_keys_str_mv | AT leonardodasilvarangel molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol AT leonardodasilvarangel molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol AT franciscopaivamachado molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol AT franciscopaivamachado molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol AT raquelamaral molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol AT anaclaudiarodriguesdasilva molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol AT anaclaudiarodriguesdasilva molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol AT marceloguerrasantos molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol AT joseaugustoalbuquerquedossantos molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol AT natalialidmarvonranke molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol AT carlosrangelrodrigues molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol AT leandrorocha molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol AT leandrorocha molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol AT leandrorocha molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol AT robsonxavierfaria molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol AT robsonxavierfaria molluskicidalnanoemulsionofneomitranthesobscuradcnsilveiraforschistosomiasiscontrol |