Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer
NFE2L3, also known as NFE2L3, is a nuclear transcription factor associated with the pathogenesis and progression of human tumors. To systematically and comprehensively investigate the role of NFE2L3 in tumors, a pan-cancer analysis was performed using multi-omics data, including gene expression anal...
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Frontiers Media S.A.
2022-06-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.916973/full |
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author | Mengxiao Liu Mengxiao Liu Mengxiao Liu Hui Wei Hui Wei Hui Wei Jing Yang Jing Yang Jing Yang Xia Chen Xia Chen Xia Chen Haoying Wang Haoying Wang Haoying Wang Ya Zheng Ya Zheng Yuping Wang Yuping Wang Yongning Zhou Yongning Zhou |
author_facet | Mengxiao Liu Mengxiao Liu Mengxiao Liu Hui Wei Hui Wei Hui Wei Jing Yang Jing Yang Jing Yang Xia Chen Xia Chen Xia Chen Haoying Wang Haoying Wang Haoying Wang Ya Zheng Ya Zheng Yuping Wang Yuping Wang Yongning Zhou Yongning Zhou |
author_sort | Mengxiao Liu |
collection | DOAJ |
description | NFE2L3, also known as NFE2L3, is a nuclear transcription factor associated with the pathogenesis and progression of human tumors. To systematically and comprehensively investigate the role of NFE2L3 in tumors, a pan-cancer analysis was performed using multi-omics data, including gene expression analysis, diagnostic and prognostic analysis, epigenetic methylation analysis, gene alteration analysis, immune feature analysis, functional enrichment analysis, and tumor cell functional status analysis. Furthermore, the molecular mechanism of NFE2L3 in liver hepatocellular carcinoma (LIHC) was explored. The relationship between NFE2L3 expression and survival prognosis of patients with LIHC was analyzed and a nomogram prediction model was constructed. Our study showed that NFE2L3 expression was upregulated in most cancers, suggesting that NFE2L3 may play an important role in promoting cancer progression. NFE2L3 expression is closely related to DNA methylation, genetic alteration, immune signature, and tumor cell functional status in pan-cancers. Furthermore, NFE2L3 was demonstrated to be an independent risk factor for LIHC, and the nomogram model based on NFE2L3 expression had good prediction efficiency for the overall survival of patients with LIHC. In summary, our study indicated that NFE2L3 may be an important molecular biomarker for the diagnosis and prognosis of pan-cancer. NFE2L3 is expected to be a potential molecular target for the treatment of tumors. |
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spelling | doaj.art-e7383d33202340d49a794ae7834741b72022-12-22T03:38:15ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-06-011310.3389/fgene.2022.916973916973Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-CancerMengxiao Liu0Mengxiao Liu1Mengxiao Liu2Hui Wei3Hui Wei4Hui Wei5Jing Yang6Jing Yang7Jing Yang8Xia Chen9Xia Chen10Xia Chen11Haoying Wang12Haoying Wang13Haoying Wang14Ya Zheng15Ya Zheng16Yuping Wang17Yuping Wang18Yongning Zhou19Yongning Zhou20The First Clinical Medical College, Lanzhou University, Lanzhou, ChinaDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, ChinaDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, ChinaDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, ChinaDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, ChinaNFE2L3, also known as NFE2L3, is a nuclear transcription factor associated with the pathogenesis and progression of human tumors. To systematically and comprehensively investigate the role of NFE2L3 in tumors, a pan-cancer analysis was performed using multi-omics data, including gene expression analysis, diagnostic and prognostic analysis, epigenetic methylation analysis, gene alteration analysis, immune feature analysis, functional enrichment analysis, and tumor cell functional status analysis. Furthermore, the molecular mechanism of NFE2L3 in liver hepatocellular carcinoma (LIHC) was explored. The relationship between NFE2L3 expression and survival prognosis of patients with LIHC was analyzed and a nomogram prediction model was constructed. Our study showed that NFE2L3 expression was upregulated in most cancers, suggesting that NFE2L3 may play an important role in promoting cancer progression. NFE2L3 expression is closely related to DNA methylation, genetic alteration, immune signature, and tumor cell functional status in pan-cancers. Furthermore, NFE2L3 was demonstrated to be an independent risk factor for LIHC, and the nomogram model based on NFE2L3 expression had good prediction efficiency for the overall survival of patients with LIHC. In summary, our study indicated that NFE2L3 may be an important molecular biomarker for the diagnosis and prognosis of pan-cancer. NFE2L3 is expected to be a potential molecular target for the treatment of tumors.https://www.frontiersin.org/articles/10.3389/fgene.2022.916973/fullNFE2L3pan-cancermulti-comicstumor immunityDNA methylation |
spellingShingle | Mengxiao Liu Mengxiao Liu Mengxiao Liu Hui Wei Hui Wei Hui Wei Jing Yang Jing Yang Jing Yang Xia Chen Xia Chen Xia Chen Haoying Wang Haoying Wang Haoying Wang Ya Zheng Ya Zheng Yuping Wang Yuping Wang Yongning Zhou Yongning Zhou Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer Frontiers in Genetics NFE2L3 pan-cancer multi-comics tumor immunity DNA methylation |
title | Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer |
title_full | Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer |
title_fullStr | Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer |
title_full_unstemmed | Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer |
title_short | Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer |
title_sort | multi omics analysis of molecular characteristics and carcinogenic effect of nfe2l3 in pan cancer |
topic | NFE2L3 pan-cancer multi-comics tumor immunity DNA methylation |
url | https://www.frontiersin.org/articles/10.3389/fgene.2022.916973/full |
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