Male Patients With Dilated Cardiomyopathy Exhibiting a Higher Heart Rate Acceleration Capacity or a Lower Deceleration Capacity Are at Higher Risk of Cardiac Death
The effects of dilated cardiomyopathy (DCM) on cardiac autonomic regulation and electrophysiology, and the consequences of such changes, remain unclear. We evaluated the associations between heart rate acceleration capacity (AC) and deceleration capacity (DC), heart structural and functional changes...
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| Format: | Article |
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Frontiers Media S.A.
2018-12-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.01774/full |
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| author | Yichen Yang Fengyan Wang Cao Zou Hongkai Dong Xingmei Huang Bingyuan Zhou Xun Li Xiangjun Yang |
| author_facet | Yichen Yang Fengyan Wang Cao Zou Hongkai Dong Xingmei Huang Bingyuan Zhou Xun Li Xiangjun Yang |
| author_sort | Yichen Yang |
| collection | DOAJ |
| description | The effects of dilated cardiomyopathy (DCM) on cardiac autonomic regulation and electrophysiology, and the consequences of such changes, remain unclear. We evaluated the associations between heart rate acceleration capacity (AC) and deceleration capacity (DC), heart structural and functional changes, and cardiac death in 202 healthy controls and 100 DCM patients. The DC was lower and the AC was higher in DCM patients (both males and females). Multivariable, linear, logistic regression analyses revealed that in males, age was positively associated with AC in healthy controls (N = 85); the left atrial diameter (LAD) was positively and the left ventricular ejection fraction (LVEF) was negatively associated with AC in DCM patients (N = 65); age was negatively associated with DC in healthy controls (N = 85); and the LAD was negatively and the LVEF was positively associated with DC in DCM patients (N = 65). In females, only age was associated with either AC or DC in healthy controls (N = 117). Kaplan–Meier analysis revealed that male DCM patients with greater LADs (≥46.5 mm) (long-rank chi-squared value = 11.1, P = 0.001), an elevated AC (≥-4.75 ms) (log-rank chi-squared value = 6.8, P = 0.009), and a lower DC (≤4.72 ms) (log-rank chi-squared value = 9.1, P = 0.003) were at higher risk of cardiac death within 60 months of follow-up. In conclusion, in males, DCM significantly affected both the AC and DC; a higher AC or a lower DC increased the risk of cardiac death. |
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| format | Article |
| id | doaj.art-e73a854581824672b35e84e9750dafb2 |
| institution | Directory Open Access Journal |
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| last_indexed | 2024-12-12T06:45:03Z |
| publishDate | 2018-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Physiology |
| spelling | doaj.art-e73a854581824672b35e84e9750dafb22022-12-22T00:34:14ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-12-01910.3389/fphys.2018.01774394869Male Patients With Dilated Cardiomyopathy Exhibiting a Higher Heart Rate Acceleration Capacity or a Lower Deceleration Capacity Are at Higher Risk of Cardiac DeathYichen Yang0Fengyan Wang1Cao Zou2Hongkai Dong3Xingmei Huang4Bingyuan Zhou5Xun Li6Xiangjun Yang7Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Cardiology, People’s Hospital of Rizhao, Rizhao, ChinaDepartment of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Cardiology, Yuncheng Central Hospital, Yuncheng, ChinaDepartment of Electrocardiography, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Echocardiography, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaThe effects of dilated cardiomyopathy (DCM) on cardiac autonomic regulation and electrophysiology, and the consequences of such changes, remain unclear. We evaluated the associations between heart rate acceleration capacity (AC) and deceleration capacity (DC), heart structural and functional changes, and cardiac death in 202 healthy controls and 100 DCM patients. The DC was lower and the AC was higher in DCM patients (both males and females). Multivariable, linear, logistic regression analyses revealed that in males, age was positively associated with AC in healthy controls (N = 85); the left atrial diameter (LAD) was positively and the left ventricular ejection fraction (LVEF) was negatively associated with AC in DCM patients (N = 65); age was negatively associated with DC in healthy controls (N = 85); and the LAD was negatively and the LVEF was positively associated with DC in DCM patients (N = 65). In females, only age was associated with either AC or DC in healthy controls (N = 117). Kaplan–Meier analysis revealed that male DCM patients with greater LADs (≥46.5 mm) (long-rank chi-squared value = 11.1, P = 0.001), an elevated AC (≥-4.75 ms) (log-rank chi-squared value = 6.8, P = 0.009), and a lower DC (≤4.72 ms) (log-rank chi-squared value = 9.1, P = 0.003) were at higher risk of cardiac death within 60 months of follow-up. In conclusion, in males, DCM significantly affected both the AC and DC; a higher AC or a lower DC increased the risk of cardiac death.https://www.frontiersin.org/article/10.3389/fphys.2018.01774/fulldilated cardiomyopathycardiac autonomic regulationelectrophysiologyheart rate acceleration capacityheart rate deceleration capacity |
| spellingShingle | Yichen Yang Fengyan Wang Cao Zou Hongkai Dong Xingmei Huang Bingyuan Zhou Xun Li Xiangjun Yang Male Patients With Dilated Cardiomyopathy Exhibiting a Higher Heart Rate Acceleration Capacity or a Lower Deceleration Capacity Are at Higher Risk of Cardiac Death Frontiers in Physiology dilated cardiomyopathy cardiac autonomic regulation electrophysiology heart rate acceleration capacity heart rate deceleration capacity |
| title | Male Patients With Dilated Cardiomyopathy Exhibiting a Higher Heart Rate Acceleration Capacity or a Lower Deceleration Capacity Are at Higher Risk of Cardiac Death |
| title_full | Male Patients With Dilated Cardiomyopathy Exhibiting a Higher Heart Rate Acceleration Capacity or a Lower Deceleration Capacity Are at Higher Risk of Cardiac Death |
| title_fullStr | Male Patients With Dilated Cardiomyopathy Exhibiting a Higher Heart Rate Acceleration Capacity or a Lower Deceleration Capacity Are at Higher Risk of Cardiac Death |
| title_full_unstemmed | Male Patients With Dilated Cardiomyopathy Exhibiting a Higher Heart Rate Acceleration Capacity or a Lower Deceleration Capacity Are at Higher Risk of Cardiac Death |
| title_short | Male Patients With Dilated Cardiomyopathy Exhibiting a Higher Heart Rate Acceleration Capacity or a Lower Deceleration Capacity Are at Higher Risk of Cardiac Death |
| title_sort | male patients with dilated cardiomyopathy exhibiting a higher heart rate acceleration capacity or a lower deceleration capacity are at higher risk of cardiac death |
| topic | dilated cardiomyopathy cardiac autonomic regulation electrophysiology heart rate acceleration capacity heart rate deceleration capacity |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.01774/full |
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