| Summary: | Introduction: Ulcerative colitis (UC) is one type of inflammatory bowel
disease (IBD). The purpose of this study is to explore the prevalence of Epstein–Barr virus
(EBV) in UC patients in comparison with healthy subjects using the polymerase chain reaction
(PCR) method. Methods: In this case-control study, five biopsies of patients with UC and 30
healthy people as controls were selected. Sampling was performed by endoscopic biopsy
operation. After DNA extraction, PCR was used to determine EBV genome by specific primers.
Statistical analysis was performed using the chi-square test. Results: The results of PCR
indicated that EBV genome was detected in 60.0% of samples in the case group, and 36.7% of
samples in the control group were positive for EBV. Thus, no significant association was
observed between the prevalence of EBV and incidence of UC in comparison with the control
group (P = 0.36). Conclusion: The findings presented herein demonstrate no direct molecular
evidence to support an association of EBV with UC. These results, do not exclude the
possibility oncogenic role of EBV to infect the different colon cell.
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