Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells
Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immatu...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/9/2087 |
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| author | Matthias Krumb Marie-Luise Frey Jens Langhanki Robert Forster Danuta Kowalczyk Volker Mailänder Katharina Landfester Till Opatz |
| author_facet | Matthias Krumb Marie-Luise Frey Jens Langhanki Robert Forster Danuta Kowalczyk Volker Mailänder Katharina Landfester Till Opatz |
| author_sort | Matthias Krumb |
| collection | DOAJ |
| description | Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immature human dendritic cells (hDCs) revealed a strong dependence on the used carbohydrate. A multivalent mannose-terminated dendron was found to be far superior in uptake compared to the structurally more complex oligosaccharides used. |
| first_indexed | 2024-03-10T16:23:01Z |
| format | Article |
| id | doaj.art-e73e72398fcb4dcca74b9b3613d0566a |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T16:23:01Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e73e72398fcb4dcca74b9b3613d0566a2023-11-20T13:31:12ZengMDPI AGCells2073-44092020-09-0199208710.3390/cells9092087Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic CellsMatthias Krumb0Marie-Luise Frey1Jens Langhanki2Robert Forster3Danuta Kowalczyk4Volker Mailänder5Katharina Landfester6Till Opatz7Department of Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz, GermanyMax Planck Institute for Polymer Research (MPIP), Ackermannweg 10, 55128 Mainz, GermanyDepartment of Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz, GermanyDepartment of Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz, GermanyDepartment of Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz, GermanyMax Planck Institute for Polymer Research (MPIP), Ackermannweg 10, 55128 Mainz, GermanyMax Planck Institute for Polymer Research (MPIP), Ackermannweg 10, 55128 Mainz, GermanyDepartment of Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz, GermanyHerein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immature human dendritic cells (hDCs) revealed a strong dependence on the used carbohydrate. A multivalent mannose-terminated dendron was found to be far superior in uptake compared to the structurally more complex oligosaccharides used.https://www.mdpi.com/2073-4409/9/9/2087carbohydratesglycodendronsdendritic cellsnanocapsulescell targeting |
| spellingShingle | Matthias Krumb Marie-Luise Frey Jens Langhanki Robert Forster Danuta Kowalczyk Volker Mailänder Katharina Landfester Till Opatz Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells Cells carbohydrates glycodendrons dendritic cells nanocapsules cell targeting |
| title | Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells |
| title_full | Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells |
| title_fullStr | Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells |
| title_full_unstemmed | Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells |
| title_short | Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells |
| title_sort | multivalency beats complexity a study on the cell uptake of carbohydrate functionalized nanocarriers to dendritic cells |
| topic | carbohydrates glycodendrons dendritic cells nanocapsules cell targeting |
| url | https://www.mdpi.com/2073-4409/9/9/2087 |
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