Deletion Mutants of <i>Francisella</i> Phagosomal Transporters FptA and FptF Are Highly Attenuated for Virulence and Are Protective Against Lethal Intranasal <i>Francisella</i> LVS Challenge in a Murine Model of Respiratory Tularemia

Deletion Mutants of <i>Francisella</i> Phagosomal Transporters FptA and FptF Are Highly Attenuated for Virulence and Are Protective Against Lethal Intranasal <i>Francisella</i> LVS Challenge in a Murine Model of Respiratory Tularemia

<i>Francisella tularensis</i> (<i>Ft</i>) is a Gram-negative, facultative intracellular bacterium that is a Tier 1 Select Agent of concern for biodefense for which there is no licensed vaccine. A subfamily of 9 <i>Francisella</i> phagosomal transporter (<i>f...

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Bibliographic Details
Main Authors: Brandi E. Hobbs, Courtney A. Matson, Vasileios I. Theofilou, Tonya J. Webb, Rania H. Younis, Eileen M. Barry
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pathogens
Subjects:
<i>Francisella tularensis</i>
Live Vaccine Strain (LVS)
live attenuated vaccine
MFS transporter
attenuation
organ burdens
Online Access:https://www.mdpi.com/2076-0817/10/7/799

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