Norovirus Capsid Protein-Derived Nanoparticles and Polymers as Versatile Platforms for Antigen Presentation and Vaccine Development
Major viral structural proteins interact homotypically and/or heterotypically, self-assembling into polyvalent viral capsids that usually elicit strong host immune responses. By taking advantage of such intrinsic features of norovirus capsids, two subviral nanoparticles, 60-valent S<sub>60<...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/11/9/472 |
| _version_ | 1798038873082691584 |
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| author | Ming Tan Xi Jiang |
| author_facet | Ming Tan Xi Jiang |
| author_sort | Ming Tan |
| collection | DOAJ |
| description | Major viral structural proteins interact homotypically and/or heterotypically, self-assembling into polyvalent viral capsids that usually elicit strong host immune responses. By taking advantage of such intrinsic features of norovirus capsids, two subviral nanoparticles, 60-valent S<sub>60</sub> and 24-valent P<sub>24</sub> nanoparticles, as well as various polymers, have been generated through bioengineering norovirus capsid shell (S) and protruding (P) domains, respectively. These nanoparticles and polymers are easily produced, highly stable, and extremely immunogenic, making them ideal vaccine candidates against noroviruses. In addition, they serve as multifunctional platforms to display foreign antigens, self-assembling into chimeric nanoparticles or polymers as vaccines against different pathogens and illnesses. Several chimeric S<sub>60</sub> and P<sub>24</sub> nanoparticles, as well as P domain-derived polymers, carrying different foreign antigens, have been created and demonstrated to be promising vaccine candidates against corresponding pathogens in preclinical animal studies, warranting their further development into useful vaccines. |
| first_indexed | 2024-04-11T21:46:18Z |
| format | Article |
| id | doaj.art-e73fc40b790d45f08588ae6ab8159a3a |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T21:46:18Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-e73fc40b790d45f08588ae6ab8159a3a2022-12-22T04:01:25ZengMDPI AGPharmaceutics1999-49232019-09-0111947210.3390/pharmaceutics11090472pharmaceutics11090472Norovirus Capsid Protein-Derived Nanoparticles and Polymers as Versatile Platforms for Antigen Presentation and Vaccine DevelopmentMing Tan0Xi Jiang1Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USAMajor viral structural proteins interact homotypically and/or heterotypically, self-assembling into polyvalent viral capsids that usually elicit strong host immune responses. By taking advantage of such intrinsic features of norovirus capsids, two subviral nanoparticles, 60-valent S<sub>60</sub> and 24-valent P<sub>24</sub> nanoparticles, as well as various polymers, have been generated through bioengineering norovirus capsid shell (S) and protruding (P) domains, respectively. These nanoparticles and polymers are easily produced, highly stable, and extremely immunogenic, making them ideal vaccine candidates against noroviruses. In addition, they serve as multifunctional platforms to display foreign antigens, self-assembling into chimeric nanoparticles or polymers as vaccines against different pathogens and illnesses. Several chimeric S<sub>60</sub> and P<sub>24</sub> nanoparticles, as well as P domain-derived polymers, carrying different foreign antigens, have been created and demonstrated to be promising vaccine candidates against corresponding pathogens in preclinical animal studies, warranting their further development into useful vaccines.https://www.mdpi.com/1999-4923/11/9/472nanoparticlevaccine platformP particleS particleprotein polymersubviral particlesubunit vaccinenorovirusrotavirushepatitis E virusastrovirus |
| spellingShingle | Ming Tan Xi Jiang Norovirus Capsid Protein-Derived Nanoparticles and Polymers as Versatile Platforms for Antigen Presentation and Vaccine Development Pharmaceutics nanoparticle vaccine platform P particle S particle protein polymer subviral particle subunit vaccine norovirus rotavirus hepatitis E virus astrovirus |
| title | Norovirus Capsid Protein-Derived Nanoparticles and Polymers as Versatile Platforms for Antigen Presentation and Vaccine Development |
| title_full | Norovirus Capsid Protein-Derived Nanoparticles and Polymers as Versatile Platforms for Antigen Presentation and Vaccine Development |
| title_fullStr | Norovirus Capsid Protein-Derived Nanoparticles and Polymers as Versatile Platforms for Antigen Presentation and Vaccine Development |
| title_full_unstemmed | Norovirus Capsid Protein-Derived Nanoparticles and Polymers as Versatile Platforms for Antigen Presentation and Vaccine Development |
| title_short | Norovirus Capsid Protein-Derived Nanoparticles and Polymers as Versatile Platforms for Antigen Presentation and Vaccine Development |
| title_sort | norovirus capsid protein derived nanoparticles and polymers as versatile platforms for antigen presentation and vaccine development |
| topic | nanoparticle vaccine platform P particle S particle protein polymer subviral particle subunit vaccine norovirus rotavirus hepatitis E virus astrovirus |
| url | https://www.mdpi.com/1999-4923/11/9/472 |
| work_keys_str_mv | AT mingtan noroviruscapsidproteinderivednanoparticlesandpolymersasversatileplatformsforantigenpresentationandvaccinedevelopment AT xijiang noroviruscapsidproteinderivednanoparticlesandpolymersasversatileplatformsforantigenpresentationandvaccinedevelopment |