Current Concepts of Neurodegenerative Diseases
Neurodegenerative diseases (NDDs) are described as disorders with selective loss of neurons and distinct involvement of functional systems defining clinical presentation. Extensive studies demonstrated that proteins with altered physicochemical properties are deposited in the human brain in NDDs. Th...
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| Format: | Article |
| Language: | English |
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European Medical Journal
2013-07-01
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| Series: | European Medical Journal Neurology |
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| Online Access: | http://emjreviews.com/wp-content/uploads/Current-Concepts-Of-Neurodegenerative-Diseases.pdf |
| _version_ | 1818821974567157760 |
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| author | Gabor G. Kovacs |
| author_facet | Gabor G. Kovacs |
| author_sort | Gabor G. Kovacs |
| collection | DOAJ |
| description | Neurodegenerative diseases (NDDs) are described as disorders with selective loss of neurons and distinct involvement of functional systems defining clinical presentation. Extensive studies demonstrated that proteins with altered physicochemical properties are deposited in the human brain in NDDs. The present review focuses on predominantly sporadic disorders in adulthood. Major concepts of NDDs can be summarised as follows: 1) molecular pathologic classification of NDDs is protein-based; 2) the proteinopathy concept underpins the role of protein processing systems; 3) seeding of pathological proteins supports the theory of prion-like spreading; 4) the clinical symptoms are determined by the system affected and do not unequivocally reflect the molecular pathological background; 5) overlapping of NDDs may be more the rule than the exception. Accordingly, NDD-related proteins and their biochemical modifications can be used as biomarkers and may be targeted for therapy. However, due to the high number of combinations of different proteinopathies a personalised therapy strategy may be warranted. |
| first_indexed | 2024-12-18T23:16:43Z |
| format | Article |
| id | doaj.art-e740003205044cb4be19d6146c8abaf1 |
| institution | Directory Open Access Journal |
| issn | 2054-4529 |
| language | English |
| last_indexed | 2024-12-18T23:16:43Z |
| publishDate | 2013-07-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal Neurology |
| spelling | doaj.art-e740003205044cb4be19d6146c8abaf12022-12-21T20:48:09ZengEuropean Medical JournalEuropean Medical Journal Neurology2054-45292013-07-01217886Current Concepts of Neurodegenerative DiseasesGabor G. Kovacs0Institute of Neurology, Medical University of Vienna, Vienna, AustriaNeurodegenerative diseases (NDDs) are described as disorders with selective loss of neurons and distinct involvement of functional systems defining clinical presentation. Extensive studies demonstrated that proteins with altered physicochemical properties are deposited in the human brain in NDDs. The present review focuses on predominantly sporadic disorders in adulthood. Major concepts of NDDs can be summarised as follows: 1) molecular pathologic classification of NDDs is protein-based; 2) the proteinopathy concept underpins the role of protein processing systems; 3) seeding of pathological proteins supports the theory of prion-like spreading; 4) the clinical symptoms are determined by the system affected and do not unequivocally reflect the molecular pathological background; 5) overlapping of NDDs may be more the rule than the exception. Accordingly, NDD-related proteins and their biochemical modifications can be used as biomarkers and may be targeted for therapy. However, due to the high number of combinations of different proteinopathies a personalised therapy strategy may be warranted.http://emjreviews.com/wp-content/uploads/Current-Concepts-Of-Neurodegenerative-Diseases.pdfBiomarkerconcomitant pathologyneurodegenerative diseaseprion-likeproteinopathy |
| spellingShingle | Gabor G. Kovacs Current Concepts of Neurodegenerative Diseases European Medical Journal Neurology Biomarker concomitant pathology neurodegenerative disease prion-like proteinopathy |
| title | Current Concepts of Neurodegenerative Diseases |
| title_full | Current Concepts of Neurodegenerative Diseases |
| title_fullStr | Current Concepts of Neurodegenerative Diseases |
| title_full_unstemmed | Current Concepts of Neurodegenerative Diseases |
| title_short | Current Concepts of Neurodegenerative Diseases |
| title_sort | current concepts of neurodegenerative diseases |
| topic | Biomarker concomitant pathology neurodegenerative disease prion-like proteinopathy |
| url | http://emjreviews.com/wp-content/uploads/Current-Concepts-Of-Neurodegenerative-Diseases.pdf |
| work_keys_str_mv | AT gaborgkovacs currentconceptsofneurodegenerativediseases |