Primary gastric non-Hodgkin's lymphoma in Chinese patients: clinical characteristics and prognostic factors
<p>Abstract</p> <p>Background</p> <p>Optimal management and outcome of primary gastric lymphoma (PGL) have not been well defined in the rituximab era. This study aimed to analyze the clinical characteristics, prognostic factors, and roles of different treatment modaliti...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-07-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/10/358 |
| _version_ | 1818471755006607360 |
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| author | Lv Yue Huang HuiQiang Xu RuiHua Jiang WenQi Huang JiaJia Xia ZhongJun Sun XiaoFei Guan ZhongZhen Lin TongYu Li ZhiMing |
| author_facet | Lv Yue Huang HuiQiang Xu RuiHua Jiang WenQi Huang JiaJia Xia ZhongJun Sun XiaoFei Guan ZhongZhen Lin TongYu Li ZhiMing |
| author_sort | Lv Yue |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Optimal management and outcome of primary gastric lymphoma (PGL) have not been well defined in the rituximab era. This study aimed to analyze the clinical characteristics, prognostic factors, and roles of different treatment modalities in Chinese patients with PGL.</p> <p>Methods</p> <p>The clinicopathological features of 83 Chinese patients with PGL were retrospectively reviewed. Staging was performed according to the Lugano staging system for gastrointestinal non-Hodgkin's lymphoma.</p> <p>Results</p> <p>The predominant pathologic subtype among Chinese patients with PGL in our study was diffuse large B cell lymphoma (DLBCL), followed by mucosa-associated lymphoid tissue (MALT) lymphoma. Among the 57 patients with gastric DLBCL, 20 patients (35.1%) were classified as the germinal center B cell-like (GCB) subtype and 37 patients (64.9%) as the non-GCB subtype. The 83 patients had a five-year overall survival (OS) and event-free survival (EFS) of 52% and 59%, respectively. Cox regression analysis showed that stage-modified international prognostic index (IPI) and performance status (PS) were independent predictors of survival. In the 67 B-cell lymphoma patients who received chemotherapy, 36 patients treated with rituximab (at least 3 cycles) had a mean OS of 72 months (95% CI 62-81) versus 62 months (95% CI 47-76) for patients without rituximab treatment (P = 0.021).</p> <p>Conclusion</p> <p>The proportion of Chinese gastric DLBCL cases with non-GCB subtype was higher than the GCB subtype. Stage-modified IPI and PS were effective prognostic factors in Chinese patients with PGL. Our data suggested that primary gastric B-cell lymphoma might have an improved outcome with rituximab in addition to chemotherapy. More studies are necessary, preferentially large prospective randomized clinical trials to obtain more information on the impact of the rituximab in the primary gastric B-cell lymphoma.</p> |
| first_indexed | 2024-04-14T03:56:39Z |
| format | Article |
| id | doaj.art-e740156ed0664b8a8bf952eeb3aa702f |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-14T03:56:39Z |
| publishDate | 2010-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-e740156ed0664b8a8bf952eeb3aa702f2022-12-22T02:13:48ZengBMCBMC Cancer1471-24072010-07-0110135810.1186/1471-2407-10-358Primary gastric non-Hodgkin's lymphoma in Chinese patients: clinical characteristics and prognostic factorsLv YueHuang HuiQiangXu RuiHuaJiang WenQiHuang JiaJiaXia ZhongJunSun XiaoFeiGuan ZhongZhenLin TongYuLi ZhiMing<p>Abstract</p> <p>Background</p> <p>Optimal management and outcome of primary gastric lymphoma (PGL) have not been well defined in the rituximab era. This study aimed to analyze the clinical characteristics, prognostic factors, and roles of different treatment modalities in Chinese patients with PGL.</p> <p>Methods</p> <p>The clinicopathological features of 83 Chinese patients with PGL were retrospectively reviewed. Staging was performed according to the Lugano staging system for gastrointestinal non-Hodgkin's lymphoma.</p> <p>Results</p> <p>The predominant pathologic subtype among Chinese patients with PGL in our study was diffuse large B cell lymphoma (DLBCL), followed by mucosa-associated lymphoid tissue (MALT) lymphoma. Among the 57 patients with gastric DLBCL, 20 patients (35.1%) were classified as the germinal center B cell-like (GCB) subtype and 37 patients (64.9%) as the non-GCB subtype. The 83 patients had a five-year overall survival (OS) and event-free survival (EFS) of 52% and 59%, respectively. Cox regression analysis showed that stage-modified international prognostic index (IPI) and performance status (PS) were independent predictors of survival. In the 67 B-cell lymphoma patients who received chemotherapy, 36 patients treated with rituximab (at least 3 cycles) had a mean OS of 72 months (95% CI 62-81) versus 62 months (95% CI 47-76) for patients without rituximab treatment (P = 0.021).</p> <p>Conclusion</p> <p>The proportion of Chinese gastric DLBCL cases with non-GCB subtype was higher than the GCB subtype. Stage-modified IPI and PS were effective prognostic factors in Chinese patients with PGL. Our data suggested that primary gastric B-cell lymphoma might have an improved outcome with rituximab in addition to chemotherapy. More studies are necessary, preferentially large prospective randomized clinical trials to obtain more information on the impact of the rituximab in the primary gastric B-cell lymphoma.</p>http://www.biomedcentral.com/1471-2407/10/358 |
| spellingShingle | Lv Yue Huang HuiQiang Xu RuiHua Jiang WenQi Huang JiaJia Xia ZhongJun Sun XiaoFei Guan ZhongZhen Lin TongYu Li ZhiMing Primary gastric non-Hodgkin's lymphoma in Chinese patients: clinical characteristics and prognostic factors BMC Cancer |
| title | Primary gastric non-Hodgkin's lymphoma in Chinese patients: clinical characteristics and prognostic factors |
| title_full | Primary gastric non-Hodgkin's lymphoma in Chinese patients: clinical characteristics and prognostic factors |
| title_fullStr | Primary gastric non-Hodgkin's lymphoma in Chinese patients: clinical characteristics and prognostic factors |
| title_full_unstemmed | Primary gastric non-Hodgkin's lymphoma in Chinese patients: clinical characteristics and prognostic factors |
| title_short | Primary gastric non-Hodgkin's lymphoma in Chinese patients: clinical characteristics and prognostic factors |
| title_sort | primary gastric non hodgkin s lymphoma in chinese patients clinical characteristics and prognostic factors |
| url | http://www.biomedcentral.com/1471-2407/10/358 |
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