THE EFFECT OF TOMATO EXTRACT (Lycopersicon esculentum) ON THE FORMATION OF ATHEROSCLEROSIS IN WHITE RATS (Rattus norvegicus) MALE
The aim of this research was to find out anti-cholesterol activity intomato extract (Lycopersicon esculentum) on blood lipid profile and its potential application in the prevention of atherosclerosis in rats fed with high cholesterol diet. This research employed a complete randomized design with uni...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Syiah Kuala, Faculty of Mathematics and Natural Science
2014-04-01
|
| Series: | Jurnal Natural |
| Online Access: | http://jurnal.unsyiah.ac.id/natural/article/view/1172 |
| _version_ | 1797229952176750592 |
|---|---|
| author | R. N. Selamet Sugito Sugito Dasrul Dasrul |
| author_facet | R. N. Selamet Sugito Sugito Dasrul Dasrul |
| author_sort | R. N. Selamet |
| collection | DOAJ |
| description | The aim of this research was to find out anti-cholesterol activity intomato extract (Lycopersicon esculentum) on blood lipid profile and its potential application in the prevention of atherosclerosis in rats fed with high cholesterol diet. This research employed a complete randomized design with unidirectional pattern by using white rats (Rattus norvegicus) divided into five groups. Negative control group was fed with standard diet, while positive control groups were fed with high cholesterol (hypercholesterolemia) diet, group K were fed
with tomato extract at a dose of 10, 20, and 40 mg/kg together with high cholesterol diet. The result of this research
showed that high cholesterol diet fed decreased simultaneously with tomato extract at a dose of 10, 20, and 40 mg /kg of rats after 60 days of treatment. Tomato extract was able prevent the formation of plaque in the coronary arteries of rats fed with hypercholesterolemia diet. Effective dose oftomatoextractused in this study was 20-40mg/kg. |
| first_indexed | 2024-04-24T15:20:46Z |
| format | Article |
| id | doaj.art-e74038769bdb433ebc4ce6b6705b6d08 |
| institution | Directory Open Access Journal |
| issn | 1411-8513 2541-4062 |
| language | English |
| last_indexed | 2024-04-24T15:20:46Z |
| publishDate | 2014-04-01 |
| publisher | Universitas Syiah Kuala, Faculty of Mathematics and Natural Science |
| record_format | Article |
| series | Jurnal Natural |
| spelling | doaj.art-e74038769bdb433ebc4ce6b6705b6d082024-04-02T08:07:36ZengUniversitas Syiah Kuala, Faculty of Mathematics and Natural ScienceJurnal Natural1411-85132541-40622014-04-011321120THE EFFECT OF TOMATO EXTRACT (Lycopersicon esculentum) ON THE FORMATION OF ATHEROSCLEROSIS IN WHITE RATS (Rattus norvegicus) MALER. N. Selamet0Sugito Sugito1Dasrul Dasrul2Magister Kesmavet, Program Pascasarjana, Universitas Syiah Kuala, Darussalam Banda - AcehMagister Kesmavet, Program Pascasarjana, Universitas Syiah Kuala, Darussalam Banda - AcehMagister Kesmavet, Program Pascasarjana, Universitas Syiah Kuala, Darussalam Banda - AcehThe aim of this research was to find out anti-cholesterol activity intomato extract (Lycopersicon esculentum) on blood lipid profile and its potential application in the prevention of atherosclerosis in rats fed with high cholesterol diet. This research employed a complete randomized design with unidirectional pattern by using white rats (Rattus norvegicus) divided into five groups. Negative control group was fed with standard diet, while positive control groups were fed with high cholesterol (hypercholesterolemia) diet, group K were fed with tomato extract at a dose of 10, 20, and 40 mg/kg together with high cholesterol diet. The result of this research showed that high cholesterol diet fed decreased simultaneously with tomato extract at a dose of 10, 20, and 40 mg /kg of rats after 60 days of treatment. Tomato extract was able prevent the formation of plaque in the coronary arteries of rats fed with hypercholesterolemia diet. Effective dose oftomatoextractused in this study was 20-40mg/kg.http://jurnal.unsyiah.ac.id/natural/article/view/1172 |
| spellingShingle | R. N. Selamet Sugito Sugito Dasrul Dasrul THE EFFECT OF TOMATO EXTRACT (Lycopersicon esculentum) ON THE FORMATION OF ATHEROSCLEROSIS IN WHITE RATS (Rattus norvegicus) MALE Jurnal Natural |
| title | THE EFFECT OF TOMATO EXTRACT (Lycopersicon esculentum) ON THE FORMATION OF ATHEROSCLEROSIS IN WHITE RATS (Rattus norvegicus) MALE |
| title_full | THE EFFECT OF TOMATO EXTRACT (Lycopersicon esculentum) ON THE FORMATION OF ATHEROSCLEROSIS IN WHITE RATS (Rattus norvegicus) MALE |
| title_fullStr | THE EFFECT OF TOMATO EXTRACT (Lycopersicon esculentum) ON THE FORMATION OF ATHEROSCLEROSIS IN WHITE RATS (Rattus norvegicus) MALE |
| title_full_unstemmed | THE EFFECT OF TOMATO EXTRACT (Lycopersicon esculentum) ON THE FORMATION OF ATHEROSCLEROSIS IN WHITE RATS (Rattus norvegicus) MALE |
| title_short | THE EFFECT OF TOMATO EXTRACT (Lycopersicon esculentum) ON THE FORMATION OF ATHEROSCLEROSIS IN WHITE RATS (Rattus norvegicus) MALE |
| title_sort | effect of tomato extract lycopersicon esculentum on the formation of atherosclerosis in white rats rattus norvegicus male |
| url | http://jurnal.unsyiah.ac.id/natural/article/view/1172 |
| work_keys_str_mv | AT rnselamet theeffectoftomatoextractlycopersiconesculentumontheformationofatherosclerosisinwhiteratsrattusnorvegicusmale AT sugitosugito theeffectoftomatoextractlycopersiconesculentumontheformationofatherosclerosisinwhiteratsrattusnorvegicusmale AT dasruldasrul theeffectoftomatoextractlycopersiconesculentumontheformationofatherosclerosisinwhiteratsrattusnorvegicusmale AT rnselamet effectoftomatoextractlycopersiconesculentumontheformationofatherosclerosisinwhiteratsrattusnorvegicusmale AT sugitosugito effectoftomatoextractlycopersiconesculentumontheformationofatherosclerosisinwhiteratsrattusnorvegicusmale AT dasruldasrul effectoftomatoextractlycopersiconesculentumontheformationofatherosclerosisinwhiteratsrattusnorvegicusmale |