Post-Vaccinal Encephalitis with Early Relapse after BNT162b2 (COMIRNATY) COVID-19 Vaccine: A Case Report
We describe the case of a 72-year-old man who received the first dose of the BNT162b2 (COMIRNATY) vaccine against COVID-19 on 18 May 2021, and the second dose on 9 September 2021. One day after receiving the first dose, he cursed with malaise, headache, fever, confusion, aggressiveness, and gait alt...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/7/1065 |
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| author | Miguel A. Vences Diego Canales Maria Fe Albujar Ebelin Barja Mary M. Araujo-Chumacero Edu Cardenas Arturo Alvarez Diego Urrunaga-Pastor |
| author_facet | Miguel A. Vences Diego Canales Maria Fe Albujar Ebelin Barja Mary M. Araujo-Chumacero Edu Cardenas Arturo Alvarez Diego Urrunaga-Pastor |
| author_sort | Miguel A. Vences |
| collection | DOAJ |
| description | We describe the case of a 72-year-old man who received the first dose of the BNT162b2 (COMIRNATY) vaccine against COVID-19 on 18 May 2021, and the second dose on 9 September 2021. One day after receiving the first dose, he cursed with malaise, headache, fever, confusion, aggressiveness, and gait alterations. We performed serum and cerebrospinal fluid (CSF) tests (finding elevated proteins in CSF) with negative results for infectious, systemic, and neoplastic causes. We performed brain nuclear magnetic resonance imaging (MRI), finding circumscribed encephalitis at the anterior frontal and bilateral temporal lobes. We were unable to perform a panel of antineuronal antibodies. The patient was readmitted due to early clinical relapse four days after receiving his second dose. We found sequelae lesions at the frontal level but with new demyelinating lesions at the left temporal level in brain MRI. We indicated methylprednisolone, and he presented a favorable improvement. We report an encephalitis case of probable autoimmune etiology after vaccination with BNT162b2, which presented early clinical relapse after receiving the second dose and presented a favorable response to methylprednisolone. |
| first_indexed | 2024-03-09T05:44:39Z |
| format | Article |
| id | doaj.art-e74120979bce472b94d5ba6ce7c6b499 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T05:44:39Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-e74120979bce472b94d5ba6ce7c6b4992023-12-03T12:22:25ZengMDPI AGVaccines2076-393X2022-07-01107106510.3390/vaccines10071065Post-Vaccinal Encephalitis with Early Relapse after BNT162b2 (COMIRNATY) COVID-19 Vaccine: A Case ReportMiguel A. Vences0Diego Canales1Maria Fe Albujar2Ebelin Barja3Mary M. Araujo-Chumacero4Edu Cardenas5Arturo Alvarez6Diego Urrunaga-Pastor7Departamento de Neurología, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima 15072, PeruDepartamento de Neurología, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima 15072, PeruDepartamento de Neurología, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima 15072, PeruDepartamento de Neurología, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima 15072, PeruDepartamento de Neurología, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima 15072, PeruDepartamento de Neurología, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima 15072, PeruDepartamento de Neurología, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima 15072, PeruUnidad para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola (USIL), Lima 15012, PeruWe describe the case of a 72-year-old man who received the first dose of the BNT162b2 (COMIRNATY) vaccine against COVID-19 on 18 May 2021, and the second dose on 9 September 2021. One day after receiving the first dose, he cursed with malaise, headache, fever, confusion, aggressiveness, and gait alterations. We performed serum and cerebrospinal fluid (CSF) tests (finding elevated proteins in CSF) with negative results for infectious, systemic, and neoplastic causes. We performed brain nuclear magnetic resonance imaging (MRI), finding circumscribed encephalitis at the anterior frontal and bilateral temporal lobes. We were unable to perform a panel of antineuronal antibodies. The patient was readmitted due to early clinical relapse four days after receiving his second dose. We found sequelae lesions at the frontal level but with new demyelinating lesions at the left temporal level in brain MRI. We indicated methylprednisolone, and he presented a favorable improvement. We report an encephalitis case of probable autoimmune etiology after vaccination with BNT162b2, which presented early clinical relapse after receiving the second dose and presented a favorable response to methylprednisolone.https://www.mdpi.com/2076-393X/10/7/1065encephalitisCOVID-19vaccinationdrug-related side effects and adverse reactionsSARS-CoV-2 |
| spellingShingle | Miguel A. Vences Diego Canales Maria Fe Albujar Ebelin Barja Mary M. Araujo-Chumacero Edu Cardenas Arturo Alvarez Diego Urrunaga-Pastor Post-Vaccinal Encephalitis with Early Relapse after BNT162b2 (COMIRNATY) COVID-19 Vaccine: A Case Report Vaccines encephalitis COVID-19 vaccination drug-related side effects and adverse reactions SARS-CoV-2 |
| title | Post-Vaccinal Encephalitis with Early Relapse after BNT162b2 (COMIRNATY) COVID-19 Vaccine: A Case Report |
| title_full | Post-Vaccinal Encephalitis with Early Relapse after BNT162b2 (COMIRNATY) COVID-19 Vaccine: A Case Report |
| title_fullStr | Post-Vaccinal Encephalitis with Early Relapse after BNT162b2 (COMIRNATY) COVID-19 Vaccine: A Case Report |
| title_full_unstemmed | Post-Vaccinal Encephalitis with Early Relapse after BNT162b2 (COMIRNATY) COVID-19 Vaccine: A Case Report |
| title_short | Post-Vaccinal Encephalitis with Early Relapse after BNT162b2 (COMIRNATY) COVID-19 Vaccine: A Case Report |
| title_sort | post vaccinal encephalitis with early relapse after bnt162b2 comirnaty covid 19 vaccine a case report |
| topic | encephalitis COVID-19 vaccination drug-related side effects and adverse reactions SARS-CoV-2 |
| url | https://www.mdpi.com/2076-393X/10/7/1065 |
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