Sarcopenia and frailty in inflammatory bowel disease: Emerging concepts and evidence
Abstract Sarcopenia is a condition marked by progressive loss of skeletal muscle mass and function while frailty is a multidimensional concept characterized by diminished physiological reserve and increased vulnerability to stressors. Both of these were previously considered as related to aging and...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.13033 |
| _version_ | 1797321325834928128 |
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| author | Pardhu B Neelam Alka Sharma Vishal Sharma |
| author_facet | Pardhu B Neelam Alka Sharma Vishal Sharma |
| author_sort | Pardhu B Neelam |
| collection | DOAJ |
| description | Abstract Sarcopenia is a condition marked by progressive loss of skeletal muscle mass and function while frailty is a multidimensional concept characterized by diminished physiological reserve and increased vulnerability to stressors. Both of these were previously considered as related to aging and shown to impact the quality of life and carry prognostic significance. Emerging data show that both sarcopenia and frailty carry similar relevance in chronic illness. Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract and malnourishment, both of which contribute to the development of sarcopenia by increasing protein breakdown and reducing protein synthesis. The coexistence of frailty further compounds the clinical complexity of IBD patients. Published evidence suggests a bidirectional association with IBD contributing to muscle wasting, while the resultant sarcopenia and frailty could further exacerbate the disease course. Sarcopenia and frailty are independently associated with adverse outcomes, including hospitalizations, increased surgical interventions, and surgical complications. As therapeutic strategies for IBD evolve, understanding the nuanced relationship between inflammatory bowel disease, sarcopenia, and frailty is crucial for devising holistic management. Comprehensive care should encompass not only disease‐modifying therapies but also interventions targeting frailty and sarcopenia, as they have been shown to have a significant impact not only on the disease course but also on the quality of life. Future research could focus on further elucidating underlying mechanisms, simple screening strategies, and developing targeted interventions to improve the overall quality of life for individuals grappling with the complex interplay of IBD, sarcopenia, and frailty. |
| first_indexed | 2024-03-08T04:56:57Z |
| format | Article |
| id | doaj.art-e741275b91d64b02b241e7ef847f2edd |
| institution | Directory Open Access Journal |
| issn | 2397-9070 |
| language | English |
| last_indexed | 2024-03-08T04:56:57Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj.art-e741275b91d64b02b241e7ef847f2edd2024-02-07T15:12:06ZengWileyJGH Open2397-90702024-01-0181n/an/a10.1002/jgh3.13033Sarcopenia and frailty in inflammatory bowel disease: Emerging concepts and evidencePardhu B Neelam0Alka Sharma1Vishal Sharma2Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh IndiaDepartment of Medicine Dr. BR Ambedkar Institute of Medical Sciences Mohali IndiaDepartment of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh IndiaAbstract Sarcopenia is a condition marked by progressive loss of skeletal muscle mass and function while frailty is a multidimensional concept characterized by diminished physiological reserve and increased vulnerability to stressors. Both of these were previously considered as related to aging and shown to impact the quality of life and carry prognostic significance. Emerging data show that both sarcopenia and frailty carry similar relevance in chronic illness. Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract and malnourishment, both of which contribute to the development of sarcopenia by increasing protein breakdown and reducing protein synthesis. The coexistence of frailty further compounds the clinical complexity of IBD patients. Published evidence suggests a bidirectional association with IBD contributing to muscle wasting, while the resultant sarcopenia and frailty could further exacerbate the disease course. Sarcopenia and frailty are independently associated with adverse outcomes, including hospitalizations, increased surgical interventions, and surgical complications. As therapeutic strategies for IBD evolve, understanding the nuanced relationship between inflammatory bowel disease, sarcopenia, and frailty is crucial for devising holistic management. Comprehensive care should encompass not only disease‐modifying therapies but also interventions targeting frailty and sarcopenia, as they have been shown to have a significant impact not only on the disease course but also on the quality of life. Future research could focus on further elucidating underlying mechanisms, simple screening strategies, and developing targeted interventions to improve the overall quality of life for individuals grappling with the complex interplay of IBD, sarcopenia, and frailty.https://doi.org/10.1002/jgh3.13033Crohn's disease muscle strengthfrailtyinflammatory bowel diseasesarcopeniaulcerative colitis |
| spellingShingle | Pardhu B Neelam Alka Sharma Vishal Sharma Sarcopenia and frailty in inflammatory bowel disease: Emerging concepts and evidence JGH Open Crohn's disease muscle strength frailty inflammatory bowel disease sarcopenia ulcerative colitis |
| title | Sarcopenia and frailty in inflammatory bowel disease: Emerging concepts and evidence |
| title_full | Sarcopenia and frailty in inflammatory bowel disease: Emerging concepts and evidence |
| title_fullStr | Sarcopenia and frailty in inflammatory bowel disease: Emerging concepts and evidence |
| title_full_unstemmed | Sarcopenia and frailty in inflammatory bowel disease: Emerging concepts and evidence |
| title_short | Sarcopenia and frailty in inflammatory bowel disease: Emerging concepts and evidence |
| title_sort | sarcopenia and frailty in inflammatory bowel disease emerging concepts and evidence |
| topic | Crohn's disease muscle strength frailty inflammatory bowel disease sarcopenia ulcerative colitis |
| url | https://doi.org/10.1002/jgh3.13033 |
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