Synthesis, spectral, thermal and biological studies of transition metal complexes of 4-hydroxy-3-[3-(4-hydroxyphenyl)-acryloyl]-6-methyl-2H-pyran-2-one
The solid complexes of Mn(II), Fe(III), Co(II), Ni(II), and Cu(II) with 4-hydroxy-3-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-methyl-2H-pyran-2-one, derived from 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione (dehydroacetic acid) and 4-hydroxybenzaldehyde, were synthesized and characterized by elemental an...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2011-09-01
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| Series: | Journal of the Serbian Chemical Society |
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| Online Access: | http://www.shd.org.rs/JSCS/Vol76/No9/06_4790_4200.pdf |
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| author | BALASAHEB R. ARBAD VAIBHAV N. PATANGE |
| author_facet | BALASAHEB R. ARBAD VAIBHAV N. PATANGE |
| author_sort | BALASAHEB R. ARBAD |
| collection | DOAJ |
| description | The solid complexes of Mn(II), Fe(III), Co(II), Ni(II), and Cu(II) with 4-hydroxy-3-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-methyl-2H-pyran-2-one, derived from 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione (dehydroacetic acid) and 4-hydroxybenzaldehyde, were synthesized and characterized by elemental analysis, conductometry, thermal analysis, magnetic measurements, IR, 1H-NMR and UV–Vis spectroscopy and a biological study. From the analytical and spectral data, the stoichiometry of the complexes was found to be 1:2 (metal:ligand). The physico–chemical data suggest a distorted octahedral geometry for the Cu(II) complexes and an octahedral geometry for all the other complexes. The thermal decomposition of all the complexes was studied by the TG–DTA method. The synthesized ligand and its metal complexes were screened for their in vitro antibacterial activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacterial strains and for in vitro antifungal activity against Aspergillus flavus, Curvularia lunata and Penicillium notatum. The results of these studies showed the metal complexes to be more antibacterial/antifungal against one or more species as compared with the non-complexed ligand. |
| first_indexed | 2024-12-17T05:00:20Z |
| format | Article |
| id | doaj.art-e7424915d6304c0cba561477b2e64a46 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-12-17T05:00:20Z |
| publishDate | 2011-09-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-e7424915d6304c0cba561477b2e64a462022-12-21T22:02:35ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392011-09-0176912371246Synthesis, spectral, thermal and biological studies of transition metal complexes of 4-hydroxy-3-[3-(4-hydroxyphenyl)-acryloyl]-6-methyl-2H-pyran-2-oneBALASAHEB R. ARBADVAIBHAV N. PATANGEThe solid complexes of Mn(II), Fe(III), Co(II), Ni(II), and Cu(II) with 4-hydroxy-3-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-methyl-2H-pyran-2-one, derived from 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione (dehydroacetic acid) and 4-hydroxybenzaldehyde, were synthesized and characterized by elemental analysis, conductometry, thermal analysis, magnetic measurements, IR, 1H-NMR and UV–Vis spectroscopy and a biological study. From the analytical and spectral data, the stoichiometry of the complexes was found to be 1:2 (metal:ligand). The physico–chemical data suggest a distorted octahedral geometry for the Cu(II) complexes and an octahedral geometry for all the other complexes. The thermal decomposition of all the complexes was studied by the TG–DTA method. The synthesized ligand and its metal complexes were screened for their in vitro antibacterial activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacterial strains and for in vitro antifungal activity against Aspergillus flavus, Curvularia lunata and Penicillium notatum. The results of these studies showed the metal complexes to be more antibacterial/antifungal against one or more species as compared with the non-complexed ligand.http://www.shd.org.rs/JSCS/Vol76/No9/06_4790_4200.pdfdehydroacetic acidbiological activitytransition metal complexes |
| spellingShingle | BALASAHEB R. ARBAD VAIBHAV N. PATANGE Synthesis, spectral, thermal and biological studies of transition metal complexes of 4-hydroxy-3-[3-(4-hydroxyphenyl)-acryloyl]-6-methyl-2H-pyran-2-one Journal of the Serbian Chemical Society dehydroacetic acid biological activity transition metal complexes |
| title | Synthesis, spectral, thermal and biological studies of transition metal complexes of 4-hydroxy-3-[3-(4-hydroxyphenyl)-acryloyl]-6-methyl-2H-pyran-2-one |
| title_full | Synthesis, spectral, thermal and biological studies of transition metal complexes of 4-hydroxy-3-[3-(4-hydroxyphenyl)-acryloyl]-6-methyl-2H-pyran-2-one |
| title_fullStr | Synthesis, spectral, thermal and biological studies of transition metal complexes of 4-hydroxy-3-[3-(4-hydroxyphenyl)-acryloyl]-6-methyl-2H-pyran-2-one |
| title_full_unstemmed | Synthesis, spectral, thermal and biological studies of transition metal complexes of 4-hydroxy-3-[3-(4-hydroxyphenyl)-acryloyl]-6-methyl-2H-pyran-2-one |
| title_short | Synthesis, spectral, thermal and biological studies of transition metal complexes of 4-hydroxy-3-[3-(4-hydroxyphenyl)-acryloyl]-6-methyl-2H-pyran-2-one |
| title_sort | synthesis spectral thermal and biological studies of transition metal complexes of 4 hydroxy 3 3 4 hydroxyphenyl acryloyl 6 methyl 2h pyran 2 one |
| topic | dehydroacetic acid biological activity transition metal complexes |
| url | http://www.shd.org.rs/JSCS/Vol76/No9/06_4790_4200.pdf |
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