OMICs-Based Strategies to Explore Stress Tolerance Mechanisms of Saccharomyces cerevisiae for Efficient Fuel Ethanol Production
Efficient biotransformation of lignocellulosic biomass to second-generation (2G) bioethanol requires promising strains harboring built-in resistance against limitations imposed by pretreated lignocellulose-derived compounds. Ethanol fermentation and stress tolerance of yeast cells are almost simulta...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Energy Research |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fenrg.2022.884582/full |
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| author | Jian-Ren Xu Jian-Ren Xu Muhammad Aamer Mehmood Lan Wang Niaz Ahmad Hai-Jun Ma Hai-Jun Ma |
| author_facet | Jian-Ren Xu Jian-Ren Xu Muhammad Aamer Mehmood Lan Wang Niaz Ahmad Hai-Jun Ma Hai-Jun Ma |
| author_sort | Jian-Ren Xu |
| collection | DOAJ |
| description | Efficient biotransformation of lignocellulosic biomass to second-generation (2G) bioethanol requires promising strains harboring built-in resistance against limitations imposed by pretreated lignocellulose-derived compounds. Ethanol fermentation and stress tolerance of yeast cells are almost simultaneously exposed to sequence variations and multiple inhibitory factors during the phases of proliferation, metabolism, and productivity. Several studies have extensively concentrated on identification or characterization of genes which confer resistance to various stresses and yeast tolerance enhancement through genetic breeding. However, the investigation of individual genes is inadequate to explain the global molecular mechanism. Herewith, “OMICs-approaches,” including genomics, transcriptomics, proteomics, and metabolomics, which are comprehensively aimed at comparative, functional profiling of the whole metabolic network, have elucidated complex cellular reactions under stressful conditions. This review briefly discusses the research progress in the field of multi-OMICs with a special focus on stress-responsive factors in frequently used S. cerevisiae. It also highlights how to promote metabolic-engineered strains for increased tolerance and higher production yield, which should be deeply exploited to achieve robustness during the lignocellulose-to-ethanol conversion process. |
| first_indexed | 2024-04-13T20:59:27Z |
| format | Article |
| id | doaj.art-e7431b02ab9f41ba84b353094cdb7022 |
| institution | Directory Open Access Journal |
| issn | 2296-598X |
| language | English |
| last_indexed | 2024-04-13T20:59:27Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Energy Research |
| spelling | doaj.art-e7431b02ab9f41ba84b353094cdb70222022-12-22T02:30:12ZengFrontiers Media S.A.Frontiers in Energy Research2296-598X2022-06-011010.3389/fenrg.2022.884582884582OMICs-Based Strategies to Explore Stress Tolerance Mechanisms of Saccharomyces cerevisiae for Efficient Fuel Ethanol ProductionJian-Ren Xu0Jian-Ren Xu1Muhammad Aamer Mehmood2Lan Wang3Niaz Ahmad4Hai-Jun Ma5Hai-Jun Ma6School of Biological Science and Engineering, North Minzu University, Yinchuan, ChinaNingxia Grape and Wine Technology Innovation Center, North Minzu University, Yinchuan, ChinaBioenergy Research Centre, Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad, PakistanSchool of Food and Wine, Ningxia University, Yinchuan, ChinaNational Institute for Biotechnology and Genetic Engineering College, Pakistan Institute of Engineering and Applied Sciences (NIBGE-C, PIEAS), Faisalabad, PakistanSchool of Biological Science and Engineering, North Minzu University, Yinchuan, ChinaNingxia Grape and Wine Technology Innovation Center, North Minzu University, Yinchuan, ChinaEfficient biotransformation of lignocellulosic biomass to second-generation (2G) bioethanol requires promising strains harboring built-in resistance against limitations imposed by pretreated lignocellulose-derived compounds. Ethanol fermentation and stress tolerance of yeast cells are almost simultaneously exposed to sequence variations and multiple inhibitory factors during the phases of proliferation, metabolism, and productivity. Several studies have extensively concentrated on identification or characterization of genes which confer resistance to various stresses and yeast tolerance enhancement through genetic breeding. However, the investigation of individual genes is inadequate to explain the global molecular mechanism. Herewith, “OMICs-approaches,” including genomics, transcriptomics, proteomics, and metabolomics, which are comprehensively aimed at comparative, functional profiling of the whole metabolic network, have elucidated complex cellular reactions under stressful conditions. This review briefly discusses the research progress in the field of multi-OMICs with a special focus on stress-responsive factors in frequently used S. cerevisiae. It also highlights how to promote metabolic-engineered strains for increased tolerance and higher production yield, which should be deeply exploited to achieve robustness during the lignocellulose-to-ethanol conversion process.https://www.frontiersin.org/articles/10.3389/fenrg.2022.884582/fullSaccharomyces cerevisiaestress toleranceomicsstrain improvementfuel ethanol production |
| spellingShingle | Jian-Ren Xu Jian-Ren Xu Muhammad Aamer Mehmood Lan Wang Niaz Ahmad Hai-Jun Ma Hai-Jun Ma OMICs-Based Strategies to Explore Stress Tolerance Mechanisms of Saccharomyces cerevisiae for Efficient Fuel Ethanol Production Frontiers in Energy Research Saccharomyces cerevisiae stress tolerance omics strain improvement fuel ethanol production |
| title | OMICs-Based Strategies to Explore Stress Tolerance Mechanisms of Saccharomyces cerevisiae for Efficient Fuel Ethanol Production |
| title_full | OMICs-Based Strategies to Explore Stress Tolerance Mechanisms of Saccharomyces cerevisiae for Efficient Fuel Ethanol Production |
| title_fullStr | OMICs-Based Strategies to Explore Stress Tolerance Mechanisms of Saccharomyces cerevisiae for Efficient Fuel Ethanol Production |
| title_full_unstemmed | OMICs-Based Strategies to Explore Stress Tolerance Mechanisms of Saccharomyces cerevisiae for Efficient Fuel Ethanol Production |
| title_short | OMICs-Based Strategies to Explore Stress Tolerance Mechanisms of Saccharomyces cerevisiae for Efficient Fuel Ethanol Production |
| title_sort | omics based strategies to explore stress tolerance mechanisms of saccharomyces cerevisiae for efficient fuel ethanol production |
| topic | Saccharomyces cerevisiae stress tolerance omics strain improvement fuel ethanol production |
| url | https://www.frontiersin.org/articles/10.3389/fenrg.2022.884582/full |
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