Anthelmintic activity of Annona crassiflora leaves against Haemonchus contortus: part 2: efficacy in vivo and blood parameters
In this study we evaluated the oral toxicity of leaf extracts of Annona crassiflora of for mice and the blood and parasitological parameters of lambs experimentally infected with Haemonchus contortus and treated with leaves of this plant. The highest dose of AE (aqueous extract) administered to mice...
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| Format: | Article |
| Language: | English |
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Universidade Federal Rural de Pernambuco
2020-04-01
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| Series: | Medicina Veterinária |
| Subjects: | |
| Online Access: | https://journals.ufrpe.br/index.php/medicinaveterinaria/article/view/3068 |
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| author | Marco Antonio Martins Caldeira Franciellen Morais-Costa Kaike Magno Macêdo Valdo Soares Martins Júnior Dheison Emanuel Augusto Pereira Ana Cláudia Maia Soares Isabela Parolis Martins Idael Matheus Goes Lopes Fernão Castro Braga Neide Judith Faria Oliveira Eduardo Robson Duarte |
| author_facet | Marco Antonio Martins Caldeira Franciellen Morais-Costa Kaike Magno Macêdo Valdo Soares Martins Júnior Dheison Emanuel Augusto Pereira Ana Cláudia Maia Soares Isabela Parolis Martins Idael Matheus Goes Lopes Fernão Castro Braga Neide Judith Faria Oliveira Eduardo Robson Duarte |
| author_sort | Marco Antonio Martins Caldeira |
| collection | DOAJ |
| description | In this study we evaluated the oral toxicity of leaf extracts of Annona crassiflora of for mice and the blood and parasitological parameters of lambs experimentally infected with Haemonchus contortus and treated with leaves of this plant. The highest dose of AE (aqueous extract) administered to mice (203.0 mg/kg bw) was well tolerated, suggesting low toxicity. At necropsy, macroscopic examination revealed no abnormalities of the evaluated viscera. Lambs infected with the nematode were divided one group treated with leaf powder and a control group that did not treat. Split-plot design analysis was performed where the treatments were defined as plots and three periods of collection were defined as subplots. Similar performances to weight gain were observed among the lamb groups. The oral administration of leaf powder at 2.75g /Kg bw did not alter the physiological blood parameters in comparison to untreated lambs; however, this dose was not efficient to fecal egg reduction. We consider that other formulations and administration protocols should be evaluated to promote an effective alternative control using the leaves of this plant. |
| first_indexed | 2024-03-12T22:55:26Z |
| format | Article |
| id | doaj.art-e74639f286d5468d81f8a9adfd226f55 |
| institution | Directory Open Access Journal |
| issn | 1809-4678 2675-6617 |
| language | English |
| last_indexed | 2024-03-12T22:55:26Z |
| publishDate | 2020-04-01 |
| publisher | Universidade Federal Rural de Pernambuco |
| record_format | Article |
| series | Medicina Veterinária |
| spelling | doaj.art-e74639f286d5468d81f8a9adfd226f552023-07-20T00:15:52ZengUniversidade Federal Rural de PernambucoMedicina Veterinária1809-46782675-66172020-04-01132Anthelmintic activity of Annona crassiflora leaves against Haemonchus contortus: part 2: efficacy in vivo and blood parametersMarco Antonio Martins Caldeira0Franciellen Morais-Costa1Kaike Magno Macêdo2Valdo Soares Martins Júnior3Dheison Emanuel Augusto Pereira4Ana Cláudia Maia Soares5Isabela Parolis Martins6Idael Matheus Goes Lopes7Fernão Castro Braga8Neide Judith Faria Oliveira9Eduardo Robson Duarte10Universidade Federal de Minas Gerais, Montes Claros-MG, Brasil.Universidade Federal de Minas Gerais, Montes Claros-MG, Brasil.Universidade Federal de Minas Gerais, Montes Claros-MG, Brasil.Universidade Federal de Minas Gerais, Montes Claros-MG, Brasil.Universidade Federal de Minas Gerais, Montes Claros-MG, Brasil.Universidade Estadual do Sudoeste da Bahia, Itapetinga-BA, Brasil.Universidade Federal de Minas Gerais, Montes Claros-MG, Brasil.Universidade Federal de Minas Gerais, Montes Claros-MG, Brasil.Universidade Federal de Minas Gerais Federal, Belo Horizonte-MG, Brasil.Universidade Federal de Minas Gerais, Montes Claros-MG, Brasil.Universidade Federal de Minas Gerais, Montes Claros-MG, Brasil.In this study we evaluated the oral toxicity of leaf extracts of Annona crassiflora of for mice and the blood and parasitological parameters of lambs experimentally infected with Haemonchus contortus and treated with leaves of this plant. The highest dose of AE (aqueous extract) administered to mice (203.0 mg/kg bw) was well tolerated, suggesting low toxicity. At necropsy, macroscopic examination revealed no abnormalities of the evaluated viscera. Lambs infected with the nematode were divided one group treated with leaf powder and a control group that did not treat. Split-plot design analysis was performed where the treatments were defined as plots and three periods of collection were defined as subplots. Similar performances to weight gain were observed among the lamb groups. The oral administration of leaf powder at 2.75g /Kg bw did not alter the physiological blood parameters in comparison to untreated lambs; however, this dose was not efficient to fecal egg reduction. We consider that other formulations and administration protocols should be evaluated to promote an effective alternative control using the leaves of this plant.https://journals.ufrpe.br/index.php/medicinaveterinaria/article/view/3068Alternative controlhaemonchosisoral toxicityblood testsCerrado. |
| spellingShingle | Marco Antonio Martins Caldeira Franciellen Morais-Costa Kaike Magno Macêdo Valdo Soares Martins Júnior Dheison Emanuel Augusto Pereira Ana Cláudia Maia Soares Isabela Parolis Martins Idael Matheus Goes Lopes Fernão Castro Braga Neide Judith Faria Oliveira Eduardo Robson Duarte Anthelmintic activity of Annona crassiflora leaves against Haemonchus contortus: part 2: efficacy in vivo and blood parameters Medicina Veterinária Alternative control haemonchosis oral toxicity blood tests Cerrado. |
| title | Anthelmintic activity of Annona crassiflora leaves against Haemonchus contortus: part 2: efficacy in vivo and blood parameters |
| title_full | Anthelmintic activity of Annona crassiflora leaves against Haemonchus contortus: part 2: efficacy in vivo and blood parameters |
| title_fullStr | Anthelmintic activity of Annona crassiflora leaves against Haemonchus contortus: part 2: efficacy in vivo and blood parameters |
| title_full_unstemmed | Anthelmintic activity of Annona crassiflora leaves against Haemonchus contortus: part 2: efficacy in vivo and blood parameters |
| title_short | Anthelmintic activity of Annona crassiflora leaves against Haemonchus contortus: part 2: efficacy in vivo and blood parameters |
| title_sort | anthelmintic activity of annona crassiflora leaves against haemonchus contortus part 2 efficacy in vivo and blood parameters |
| topic | Alternative control haemonchosis oral toxicity blood tests Cerrado. |
| url | https://journals.ufrpe.br/index.php/medicinaveterinaria/article/view/3068 |
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