HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury

HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury

Acute lung injury (ALI) is a severe form of lung inflammation causing acute respiratory distress syndrome in patients. ALI pathogenesis is closely linked to uncontrolled alveolar inflammation. We hypothesize that specific enzymes of the glycolytic pathway could function as key regulators of alveolar...

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Bibliographic Details
Main Authors: Christine U. Vohwinkel, Nana Burns, Ethan Coit, Xiaoyi Yuan, Eszter K. Vladar, Christina Sul, Eric P. Schmidt, Peter Carmeliet, Kurt Stenmark, Eva S. Nozik, Rubin M. Tuder, Holger K. Eltzschig
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-12-01
Series:JCI Insight
Subjects:
Metabolism
Pulmonology
Online Access:https://doi.org/10.1172/jci.insight.157855

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