Inhibition of lysophosphatidic acid receptor 1 relieves PMN recruitment in CNS via LPA1/TSP1/CXCR2 pathway and alleviates disruption on blood-brain barrier following intracerebral haemorrhage in mice

Inhibition of lysophosphatidic acid receptor 1 relieves PMN recruitment in CNS via LPA1/TSP1/CXCR2 pathway and alleviates disruption on blood-brain barrier following intracerebral haemorrhage in mice

Abstract Backgroud The frequencies of morbidity and impairment associated with spontaneous intracerebral haemorrhage (ICH) are comparatively high. Blood-brain barrier (BBB) integrity was compromised due to subsequent brain injury induced by ICH, which is crucial for a poor prognosis. Polymorphonucle...

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Bibliographic Details
Main Authors: Ling Gao, Li Peng, Prativa Sherchan, Hong Tang, Yu Liu, Jie Xiao, Hui Shi, Yujie Luo, Jiping Tang, John H. Zhang, Ying Xia
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Fluids and Barriers of the CNS
Subjects:
Lysophosphatidic acid receptor 1
Intracerebral haemorrhage
AM966
Blood-brain barrier
Polymorphonuclear leukocyte
Online Access:https://doi.org/10.1186/s12987-023-00434-3

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