Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone
Abstract Carbapenem-resistant Escherichia coli (CREC) ST410 has recently emerged as a major global health problem. Here, we report a shift in CREC prevalence in Chinese hospitals between 2017 and 2021 with ST410 becoming the most commonly isolated sequence type. Genomic analysis identifies a hypervi...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-43854-3 |
| _version_ | 1827382166161457152 |
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| author | Xiaoliang Ba Yingyi Guo Robert A. Moran Emma L. Doughty Baomo Liu Likang Yao Jiahui Li Nanhao He Siquan Shen Yang Li Willem van Schaik Alan McNally Mark A. Holmes Chao Zhuo |
| author_facet | Xiaoliang Ba Yingyi Guo Robert A. Moran Emma L. Doughty Baomo Liu Likang Yao Jiahui Li Nanhao He Siquan Shen Yang Li Willem van Schaik Alan McNally Mark A. Holmes Chao Zhuo |
| author_sort | Xiaoliang Ba |
| collection | DOAJ |
| description | Abstract Carbapenem-resistant Escherichia coli (CREC) ST410 has recently emerged as a major global health problem. Here, we report a shift in CREC prevalence in Chinese hospitals between 2017 and 2021 with ST410 becoming the most commonly isolated sequence type. Genomic analysis identifies a hypervirulent CREC ST410 clone, B5/H24RxC, which caused two separate outbreaks in a children’s hospital. It may have emerged from the previously characterised B4/H24RxC in 2006 and has been isolated in ten other countries from 2015 to 2021. Compared with B4/H24RxC, B5/H24RxC lacks the bla OXA-181-bearing X3 plasmid, but carries a F-type plasmid containing bla NDM-5. Most of B5/H24RxC also carry a high pathogenicity island and a novel O-antigen gene cluster. We find that B5/H24RxC grew faster in vitro and is more virulent in vivo. The identification of this newly emerged but already globally disseminated hypervirulent CREC clone, highlights the ongoing evolution of ST410 towards increased resistance and virulence. |
| first_indexed | 2024-03-08T14:15:38Z |
| format | Article |
| id | doaj.art-e74bbf0bda7144809927f3cba2d259e0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-08T14:15:38Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e74bbf0bda7144809927f3cba2d259e02024-01-14T12:27:56ZengNature PortfolioNature Communications2041-17232024-01-0115111510.1038/s41467-023-43854-3Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 cloneXiaoliang Ba0Yingyi Guo1Robert A. Moran2Emma L. Doughty3Baomo Liu4Likang Yao5Jiahui Li6Nanhao He7Siquan Shen8Yang Li9Willem van Schaik10Alan McNally11Mark A. Holmes12Chao Zhuo13Department of Veterinary Medicine, University of CambridgeState Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical UniversityInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of BirminghamInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of BirminghamDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen UniversityState Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical UniversityInstitute of Antibiotics, Huashan Hospital, Fudan UniversityDepartment of Clinical Laboratory, Children’s Hospital of Soochow UniversityInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of BirminghamInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of BirminghamDepartment of Veterinary Medicine, University of CambridgeState Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical UniversityAbstract Carbapenem-resistant Escherichia coli (CREC) ST410 has recently emerged as a major global health problem. Here, we report a shift in CREC prevalence in Chinese hospitals between 2017 and 2021 with ST410 becoming the most commonly isolated sequence type. Genomic analysis identifies a hypervirulent CREC ST410 clone, B5/H24RxC, which caused two separate outbreaks in a children’s hospital. It may have emerged from the previously characterised B4/H24RxC in 2006 and has been isolated in ten other countries from 2015 to 2021. Compared with B4/H24RxC, B5/H24RxC lacks the bla OXA-181-bearing X3 plasmid, but carries a F-type plasmid containing bla NDM-5. Most of B5/H24RxC also carry a high pathogenicity island and a novel O-antigen gene cluster. We find that B5/H24RxC grew faster in vitro and is more virulent in vivo. The identification of this newly emerged but already globally disseminated hypervirulent CREC clone, highlights the ongoing evolution of ST410 towards increased resistance and virulence.https://doi.org/10.1038/s41467-023-43854-3 |
| spellingShingle | Xiaoliang Ba Yingyi Guo Robert A. Moran Emma L. Doughty Baomo Liu Likang Yao Jiahui Li Nanhao He Siquan Shen Yang Li Willem van Schaik Alan McNally Mark A. Holmes Chao Zhuo Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone Nature Communications |
| title | Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone |
| title_full | Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone |
| title_fullStr | Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone |
| title_full_unstemmed | Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone |
| title_short | Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone |
| title_sort | global emergence of a hypervirulent carbapenem resistant escherichia coli st410 clone |
| url | https://doi.org/10.1038/s41467-023-43854-3 |
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