Emerging roles of miR-145 in gastrointestinal cancers: A new paradigm
Gastrointestinal (GI) carcinomas are a group of cancers affecting the GI tract and digestive organs, such as the gastric, liver, bile ducts, pancreas, small intestine, esophagus, colon, and rectum. MicroRNAs (miRNAs) are small functional non-coding RNAs (ncRNAs) which are involved in regulating the...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223010557 |
| _version_ | 1797686898419826688 |
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| author | Mohammad Roshani Danial Molavizadeh Sara Sadeghi Ameneh Jafari Fatemeh Dashti Seyed Mohammad Ali Mirazimi Sahar Ahmadi Asouri Ali Rajabi Michael R. Hamblin Ali Arash Anoushirvani Hamed Mirzaei |
| author_facet | Mohammad Roshani Danial Molavizadeh Sara Sadeghi Ameneh Jafari Fatemeh Dashti Seyed Mohammad Ali Mirazimi Sahar Ahmadi Asouri Ali Rajabi Michael R. Hamblin Ali Arash Anoushirvani Hamed Mirzaei |
| author_sort | Mohammad Roshani |
| collection | DOAJ |
| description | Gastrointestinal (GI) carcinomas are a group of cancers affecting the GI tract and digestive organs, such as the gastric, liver, bile ducts, pancreas, small intestine, esophagus, colon, and rectum. MicroRNAs (miRNAs) are small functional non-coding RNAs (ncRNAs) which are involved in regulating the expression of multiple target genes; mainly at the post-transcriptional level, via complementary binding to their 3′‐untranslated region (3′‐UTR). Increasing evidence has shown that miRNAs have critical roles in modulating of various physiological and pathological cellular processes and regulating the occurrence and development of human malignancies. Among them, miR-145 is recognized for its anti-oncogenic properties in various cancers, including GI cancers. MiR-145 has been implicated in diverse biological processes of cancers through the regulation of target genes or signaling, including, proliferation, differentiation, tumorigenesis, angiogenesis, apoptosis, metastasis, and therapy resistance. In this review, we have summarized the role of miR-145 in selected GI cancers and also its downstream molecules and cellular processes targets, which could lead to a better understanding of the miR-145 in these cancers. In conclusion, we reveal the potential diagnostic, prognostic, and therapeutic value of miR-145 in GI cancer, and hope to provide new ideas for its application as a biomarker as well as a therapeutic target for the treatment of these cancer. |
| first_indexed | 2024-03-12T01:12:16Z |
| format | Article |
| id | doaj.art-e74d4b59bd444a069d90354702c0005d |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T01:12:16Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-e74d4b59bd444a069d90354702c0005d2023-09-14T04:52:29ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-10-01166115264Emerging roles of miR-145 in gastrointestinal cancers: A new paradigmMohammad Roshani0Danial Molavizadeh1Sara Sadeghi2Ameneh Jafari3Fatemeh Dashti4Seyed Mohammad Ali Mirazimi5Sahar Ahmadi Asouri6Ali Rajabi7Michael R. Hamblin8Ali Arash Anoushirvani9Hamed Mirzaei10Internal Medicine and Gastroenterology, Colorectal Research Center, Iran University of Medical Sciences, Tehran, IranSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran; Research Committee, Kashan University of Medical Sciences, Kashan, IranSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran; Research Committee, Kashan University of Medical Sciences, Kashan, IranProteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran; Research Committee, Kashan University of Medical Sciences, Kashan, IranSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran; Research Committee, Kashan University of Medical Sciences, Kashan, IranResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for BasicSciences, Kashan University of Medical Sciences, Kashan, IranSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran; Research Committee, Kashan University of Medical Sciences, Kashan, IranLaser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South AfricaDepartment of Internal Medicine, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Corresponding author.Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Internal Medicine, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Corresponding author at: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.Gastrointestinal (GI) carcinomas are a group of cancers affecting the GI tract and digestive organs, such as the gastric, liver, bile ducts, pancreas, small intestine, esophagus, colon, and rectum. MicroRNAs (miRNAs) are small functional non-coding RNAs (ncRNAs) which are involved in regulating the expression of multiple target genes; mainly at the post-transcriptional level, via complementary binding to their 3′‐untranslated region (3′‐UTR). Increasing evidence has shown that miRNAs have critical roles in modulating of various physiological and pathological cellular processes and regulating the occurrence and development of human malignancies. Among them, miR-145 is recognized for its anti-oncogenic properties in various cancers, including GI cancers. MiR-145 has been implicated in diverse biological processes of cancers through the regulation of target genes or signaling, including, proliferation, differentiation, tumorigenesis, angiogenesis, apoptosis, metastasis, and therapy resistance. In this review, we have summarized the role of miR-145 in selected GI cancers and also its downstream molecules and cellular processes targets, which could lead to a better understanding of the miR-145 in these cancers. In conclusion, we reveal the potential diagnostic, prognostic, and therapeutic value of miR-145 in GI cancer, and hope to provide new ideas for its application as a biomarker as well as a therapeutic target for the treatment of these cancer.http://www.sciencedirect.com/science/article/pii/S0753332223010557Gastrointestinal cancersMicroRNAMiR-145Tumor suppressor |
| spellingShingle | Mohammad Roshani Danial Molavizadeh Sara Sadeghi Ameneh Jafari Fatemeh Dashti Seyed Mohammad Ali Mirazimi Sahar Ahmadi Asouri Ali Rajabi Michael R. Hamblin Ali Arash Anoushirvani Hamed Mirzaei Emerging roles of miR-145 in gastrointestinal cancers: A new paradigm Biomedicine & Pharmacotherapy Gastrointestinal cancers MicroRNA MiR-145 Tumor suppressor |
| title | Emerging roles of miR-145 in gastrointestinal cancers: A new paradigm |
| title_full | Emerging roles of miR-145 in gastrointestinal cancers: A new paradigm |
| title_fullStr | Emerging roles of miR-145 in gastrointestinal cancers: A new paradigm |
| title_full_unstemmed | Emerging roles of miR-145 in gastrointestinal cancers: A new paradigm |
| title_short | Emerging roles of miR-145 in gastrointestinal cancers: A new paradigm |
| title_sort | emerging roles of mir 145 in gastrointestinal cancers a new paradigm |
| topic | Gastrointestinal cancers MicroRNA MiR-145 Tumor suppressor |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223010557 |
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