Effects of ferulic acid on the growth performance, physiological and biochemical functions, and hepato-intestinal health of blunt snout bream, Megalobrama amblycephala
To investigate the impact of dietary inclusion of ferulic acid (FA) on growth performance, physiological and biochemical functions and hepato-intestinal health, three iso-nitrogenous and iso-lipidic diets supplemented with 0 mg/kg, 100 mg/kg, and 200 mg/kg FA were fed to Megalobrama amblycephala (9....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Aquaculture Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352513423004180 |
| _version_ | 1797388778264854528 |
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| author | Yan Lin Linghong Miao Xiaoqin Li Linjie Qian Qiaoqiao Mu Bo Liu Xianping Ge Xiangjun Leng |
| author_facet | Yan Lin Linghong Miao Xiaoqin Li Linjie Qian Qiaoqiao Mu Bo Liu Xianping Ge Xiangjun Leng |
| author_sort | Yan Lin |
| collection | DOAJ |
| description | To investigate the impact of dietary inclusion of ferulic acid (FA) on growth performance, physiological and biochemical functions and hepato-intestinal health, three iso-nitrogenous and iso-lipidic diets supplemented with 0 mg/kg, 100 mg/kg, and 200 mg/kg FA were fed to Megalobrama amblycephala (9.75 ± 0.04 g) for 8 weeks. The growth performance, physiological and biochemical parameters, antioxidant capacity and the expression of genes were assessed on 4th and 8th week. The results indicated that 100 mg/kg FA inclusion significantly enhanced the weight gain rate (on week 4 and 8), feed intake (on 4th week), protein efficiency ratio (on week 8) and condition factor (on week 4) (P < 0.05). In plasma biochemical index, dietary FA significantly reduced the contents of alanine aminotransferase, glucose and lactate dehydrogenase on 8th week (P < 0.05). In the antioxidant capacity, dietary FA decreased the malondialdehyde (MDA) content in hepatopancreas and intestine (P < 0.05), while increased the activities of total superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and glutathione S-transferase (P < 0.05), and the best effects were observed at 100 mg/kg FA inclusion on 8th week. On 8th week, the supplementation of 100 mg/kg FA down-regulated the expression levels of inflammation-related genes (interleukin-6, interleukin-1β (hepatopancreas only), nuclear factor-κB), pro-apoptotic gene caspase-8 and endoplasmic reticulum stress-related genes (X-box-binding protein 1 S, protein kinase R-like ER kinase, inositol requiring enzyme 1, C/EBP homologous protein, immunoglobulin binding protein (hepatopancreas only), activated transcription factor 6α, activated transcription factor 4) (P < 0.05), while the anti-apoptotic gene B lymphoblastoma-2 was significantly up-regulated (P < 0.05). In conclusion, FA enhanced the growth performance, antioxidant and anti-inflammatory properties, reduced apoptosis level, and maintained the hepato-intestinal endoplasmic reticulum homeostasis. The FA inclusion was suggested at 100 mg/kg. |
| first_indexed | 2024-03-08T22:45:45Z |
| format | Article |
| id | doaj.art-e74f67d472d84b98ace0ef1baaaa5954 |
| institution | Directory Open Access Journal |
| issn | 2352-5134 |
| language | English |
| last_indexed | 2024-03-08T22:45:45Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aquaculture Reports |
| spelling | doaj.art-e74f67d472d84b98ace0ef1baaaa59542023-12-17T06:40:04ZengElsevierAquaculture Reports2352-51342023-12-0133101879Effects of ferulic acid on the growth performance, physiological and biochemical functions, and hepato-intestinal health of blunt snout bream, Megalobrama amblycephalaYan Lin0Linghong Miao1Xiaoqin Li2Linjie Qian3Qiaoqiao Mu4Bo Liu5Xianping Ge6Xiangjun Leng7National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China; Centre for Research on Environmental Ecology and Fish Nutrition (CREEFN) of the Ministry of Agriculture and Rural Affairs, Shanghai Ocean University, Shanghai 201306, China; Shanghai Collaborative Innovation for Aquatic Animal Genetics and Breeding, Shanghai Ocean University, Shanghai 201306, China; Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Key Laboratory of Aquatic Animal Nutrition and Health, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, ChinaKey Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Key Laboratory of Aquatic Animal Nutrition and Health, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, ChinaNational Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China; Centre for Research on Environmental Ecology and Fish Nutrition (CREEFN) of the Ministry of Agriculture and Rural Affairs, Shanghai Ocean University, Shanghai 201306, China; Shanghai Collaborative Innovation for Aquatic Animal Genetics and Breeding, Shanghai Ocean University, Shanghai 201306, ChinaWuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, ChinaWuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, ChinaKey Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Key Laboratory of Aquatic Animal Nutrition and Health, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, ChinaKey Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Key Laboratory of Aquatic Animal Nutrition and Health, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China; Correspondence to: Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, No. 9 Shanshui East Road, Wuxi, Jiangsu 214081, China.National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China; Centre for Research on Environmental Ecology and Fish Nutrition (CREEFN) of the Ministry of Agriculture and Rural Affairs, Shanghai Ocean University, Shanghai 201306, China; Shanghai Collaborative Innovation for Aquatic Animal Genetics and Breeding, Shanghai Ocean University, Shanghai 201306, China; Correspondence to: Shanghai Ocean University, Hucheng Ring road 999, Lingang New City, Shanghai 201306, China.To investigate the impact of dietary inclusion of ferulic acid (FA) on growth performance, physiological and biochemical functions and hepato-intestinal health, three iso-nitrogenous and iso-lipidic diets supplemented with 0 mg/kg, 100 mg/kg, and 200 mg/kg FA were fed to Megalobrama amblycephala (9.75 ± 0.04 g) for 8 weeks. The growth performance, physiological and biochemical parameters, antioxidant capacity and the expression of genes were assessed on 4th and 8th week. The results indicated that 100 mg/kg FA inclusion significantly enhanced the weight gain rate (on week 4 and 8), feed intake (on 4th week), protein efficiency ratio (on week 8) and condition factor (on week 4) (P < 0.05). In plasma biochemical index, dietary FA significantly reduced the contents of alanine aminotransferase, glucose and lactate dehydrogenase on 8th week (P < 0.05). In the antioxidant capacity, dietary FA decreased the malondialdehyde (MDA) content in hepatopancreas and intestine (P < 0.05), while increased the activities of total superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and glutathione S-transferase (P < 0.05), and the best effects were observed at 100 mg/kg FA inclusion on 8th week. On 8th week, the supplementation of 100 mg/kg FA down-regulated the expression levels of inflammation-related genes (interleukin-6, interleukin-1β (hepatopancreas only), nuclear factor-κB), pro-apoptotic gene caspase-8 and endoplasmic reticulum stress-related genes (X-box-binding protein 1 S, protein kinase R-like ER kinase, inositol requiring enzyme 1, C/EBP homologous protein, immunoglobulin binding protein (hepatopancreas only), activated transcription factor 6α, activated transcription factor 4) (P < 0.05), while the anti-apoptotic gene B lymphoblastoma-2 was significantly up-regulated (P < 0.05). In conclusion, FA enhanced the growth performance, antioxidant and anti-inflammatory properties, reduced apoptosis level, and maintained the hepato-intestinal endoplasmic reticulum homeostasis. The FA inclusion was suggested at 100 mg/kg.http://www.sciencedirect.com/science/article/pii/S2352513423004180Antioxidant and anti-inflammatoryEndoplasmic reticulum stressFerulic acidHepato-intestinal healthGrowth performance |
| spellingShingle | Yan Lin Linghong Miao Xiaoqin Li Linjie Qian Qiaoqiao Mu Bo Liu Xianping Ge Xiangjun Leng Effects of ferulic acid on the growth performance, physiological and biochemical functions, and hepato-intestinal health of blunt snout bream, Megalobrama amblycephala Aquaculture Reports Antioxidant and anti-inflammatory Endoplasmic reticulum stress Ferulic acid Hepato-intestinal health Growth performance |
| title | Effects of ferulic acid on the growth performance, physiological and biochemical functions, and hepato-intestinal health of blunt snout bream, Megalobrama amblycephala |
| title_full | Effects of ferulic acid on the growth performance, physiological and biochemical functions, and hepato-intestinal health of blunt snout bream, Megalobrama amblycephala |
| title_fullStr | Effects of ferulic acid on the growth performance, physiological and biochemical functions, and hepato-intestinal health of blunt snout bream, Megalobrama amblycephala |
| title_full_unstemmed | Effects of ferulic acid on the growth performance, physiological and biochemical functions, and hepato-intestinal health of blunt snout bream, Megalobrama amblycephala |
| title_short | Effects of ferulic acid on the growth performance, physiological and biochemical functions, and hepato-intestinal health of blunt snout bream, Megalobrama amblycephala |
| title_sort | effects of ferulic acid on the growth performance physiological and biochemical functions and hepato intestinal health of blunt snout bream megalobrama amblycephala |
| topic | Antioxidant and anti-inflammatory Endoplasmic reticulum stress Ferulic acid Hepato-intestinal health Growth performance |
| url | http://www.sciencedirect.com/science/article/pii/S2352513423004180 |
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