Circulating Cytokines Predict 1H-Proton MRS Cerebral Metabolites in Healthy Older Adults
Background: Changes in both circulating cytokines and neurochemical concentrations have been observed in aging. Patterns of change across these factors are associated with age-related pathologies, including neurodegenerative disease. More evidence to define patterns of change that are characteristic...
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| Format: | Article |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.690923/full |
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| author | Kailey Langer Kailey Langer Ronald A. Cohen Ronald A. Cohen Eric C. Porges Eric C. Porges John B. Williamson John B. Williamson Adam J. Woods Adam J. Woods |
| author_facet | Kailey Langer Kailey Langer Ronald A. Cohen Ronald A. Cohen Eric C. Porges Eric C. Porges John B. Williamson John B. Williamson Adam J. Woods Adam J. Woods |
| author_sort | Kailey Langer |
| collection | DOAJ |
| description | Background: Changes in both circulating cytokines and neurochemical concentrations have been observed in aging. Patterns of change across these factors are associated with age-related pathologies, including neurodegenerative disease. More evidence to define patterns of change that are characteristic of healthy aging is needed, as is an investigation into how age-related changes in blood cytokines and brain neurochemicals may relate to one another in a healthy older adult population.Methods: Single voxel 1H-proton magnetic resonance spectroscopy was collected in medial frontal and medial parietal regions. Phosphocholine and glycerophosphocholine (Cho), myo-inositol (MI), N-acetylaspertate and N-acetylasperglutamate (NAA), creatine and phosphocreatine (Cr), and glutamate and glutamine (Glx) were measured in a sample of 83 healthy, cognitively normal adults aged 52–89. Blood data were collected to quantify 12 cytokines: interleukins (IL-) 2, 5, 6, 7, 8, 10, 12, 13, IL-1 β, tumor necrosis factor α (TNF-α), interferon γ (IFN-γ), and IL-17 α. Correlation analyses were performed to assess age relationships between each of these factors. Backward linear regressions were performed. Cytokine data and age were used as predictors of each cerebrospinal fluid (CSF)-corrected metabolite concentration in both voxels.Results: Associations were identified between a variety of cytokines and concentrations of frontal NAA, Cr, and Glx, and of parietal MI, Cho, NAA, and Cr. In the frontal voxel, NAA was predicted by more IL-1B and less TNF-α, Cr by less TNF-α and more IL-5, and Glx by less TNF-α. In the parietal voxel, MI was predicted by more IL-10 and IL-8 and less IL-2, Cho by more TNF-α and less IL-2, NAA by more IL-1B and TNF-α and less IL-13, IL-2, and IL-7, and Cr by more IL-10 and less IL-2.Conclusions: Associations were identified between circulating cytokines and neurometabolite concentrations in this sample of older adults. The present results serve as the initial evidence of relationships between circulating cytokines and neurophysiology. Findings invite further investigation to understand the physiological consequences of aging, and how peripheral inflammatory markers may relate to neurochemical concentrations in healthy aging. |
| first_indexed | 2024-12-16T12:26:20Z |
| format | Article |
| id | doaj.art-e74f8985728941698d77cf164fe41ab9 |
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| language | English |
| last_indexed | 2024-12-16T12:26:20Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-e74f8985728941698d77cf164fe41ab92022-12-21T22:31:49ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-08-011310.3389/fnagi.2021.690923690923Circulating Cytokines Predict 1H-Proton MRS Cerebral Metabolites in Healthy Older AdultsKailey Langer0Kailey Langer1Ronald A. Cohen2Ronald A. Cohen3Eric C. Porges4Eric C. Porges5John B. Williamson6John B. Williamson7Adam J. Woods8Adam J. Woods9Center for Cognitive Aging and Memory, Clinical Translational Research Program, College of Medicine, University of Florida, Gainesville, FL, United StatesDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United StatesCenter for Cognitive Aging and Memory, Clinical Translational Research Program, College of Medicine, University of Florida, Gainesville, FL, United StatesDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United StatesCenter for Cognitive Aging and Memory, Clinical Translational Research Program, College of Medicine, University of Florida, Gainesville, FL, United StatesDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United StatesCenter for Cognitive Aging and Memory, Clinical Translational Research Program, College of Medicine, University of Florida, Gainesville, FL, United StatesDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United StatesCenter for Cognitive Aging and Memory, Clinical Translational Research Program, College of Medicine, University of Florida, Gainesville, FL, United StatesDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United StatesBackground: Changes in both circulating cytokines and neurochemical concentrations have been observed in aging. Patterns of change across these factors are associated with age-related pathologies, including neurodegenerative disease. More evidence to define patterns of change that are characteristic of healthy aging is needed, as is an investigation into how age-related changes in blood cytokines and brain neurochemicals may relate to one another in a healthy older adult population.Methods: Single voxel 1H-proton magnetic resonance spectroscopy was collected in medial frontal and medial parietal regions. Phosphocholine and glycerophosphocholine (Cho), myo-inositol (MI), N-acetylaspertate and N-acetylasperglutamate (NAA), creatine and phosphocreatine (Cr), and glutamate and glutamine (Glx) were measured in a sample of 83 healthy, cognitively normal adults aged 52–89. Blood data were collected to quantify 12 cytokines: interleukins (IL-) 2, 5, 6, 7, 8, 10, 12, 13, IL-1 β, tumor necrosis factor α (TNF-α), interferon γ (IFN-γ), and IL-17 α. Correlation analyses were performed to assess age relationships between each of these factors. Backward linear regressions were performed. Cytokine data and age were used as predictors of each cerebrospinal fluid (CSF)-corrected metabolite concentration in both voxels.Results: Associations were identified between a variety of cytokines and concentrations of frontal NAA, Cr, and Glx, and of parietal MI, Cho, NAA, and Cr. In the frontal voxel, NAA was predicted by more IL-1B and less TNF-α, Cr by less TNF-α and more IL-5, and Glx by less TNF-α. In the parietal voxel, MI was predicted by more IL-10 and IL-8 and less IL-2, Cho by more TNF-α and less IL-2, NAA by more IL-1B and TNF-α and less IL-13, IL-2, and IL-7, and Cr by more IL-10 and less IL-2.Conclusions: Associations were identified between circulating cytokines and neurometabolite concentrations in this sample of older adults. The present results serve as the initial evidence of relationships between circulating cytokines and neurophysiology. Findings invite further investigation to understand the physiological consequences of aging, and how peripheral inflammatory markers may relate to neurochemical concentrations in healthy aging.https://www.frontiersin.org/articles/10.3389/fnagi.2021.690923/fullagingMRScerebral metabolitescytokinestumor necrosis factor-α |
| spellingShingle | Kailey Langer Kailey Langer Ronald A. Cohen Ronald A. Cohen Eric C. Porges Eric C. Porges John B. Williamson John B. Williamson Adam J. Woods Adam J. Woods Circulating Cytokines Predict 1H-Proton MRS Cerebral Metabolites in Healthy Older Adults Frontiers in Aging Neuroscience aging MRS cerebral metabolites cytokines tumor necrosis factor-α |
| title | Circulating Cytokines Predict 1H-Proton MRS Cerebral Metabolites in Healthy Older Adults |
| title_full | Circulating Cytokines Predict 1H-Proton MRS Cerebral Metabolites in Healthy Older Adults |
| title_fullStr | Circulating Cytokines Predict 1H-Proton MRS Cerebral Metabolites in Healthy Older Adults |
| title_full_unstemmed | Circulating Cytokines Predict 1H-Proton MRS Cerebral Metabolites in Healthy Older Adults |
| title_short | Circulating Cytokines Predict 1H-Proton MRS Cerebral Metabolites in Healthy Older Adults |
| title_sort | circulating cytokines predict 1h proton mrs cerebral metabolites in healthy older adults |
| topic | aging MRS cerebral metabolites cytokines tumor necrosis factor-α |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.690923/full |
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