Non-Coding RNAs in Normal B-Cell Development and in Mantle Cell Lymphoma: From Molecular Mechanism to Biomarker and Therapeutic Agent Potential
B-lymphocytes are essential for an efficient immune response against a variety of pathogens. A large fraction of hematologic malignancies are of B-cell origin, suggesting that the development and activation of B cells must be tightly regulated. In recent years, differentially expressed non-coding RN...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/17/9490 |
| _version_ | 1797521341715316736 |
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| author | Olga Kersy Mali Salmon-Divon Ofer Shpilberg Oshrat Hershkovitz-Rokah |
| author_facet | Olga Kersy Mali Salmon-Divon Ofer Shpilberg Oshrat Hershkovitz-Rokah |
| author_sort | Olga Kersy |
| collection | DOAJ |
| description | B-lymphocytes are essential for an efficient immune response against a variety of pathogens. A large fraction of hematologic malignancies are of B-cell origin, suggesting that the development and activation of B cells must be tightly regulated. In recent years, differentially expressed non-coding RNAs have been identified in mantle cell lymphoma (MCL) tumor samples as opposed to their naive, normal B-cell compartment. These aberrantly expressed molecules, specifically microRNAs (miRNAs), circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs), have a role in cellular growth and survival pathways in various biological models. Here, we provide an overview of current knowledge on the role of non-coding RNAs and their relevant targets in B-cell development, activation and malignant transformation, summarizing the current understanding of the role of aberrant expression of non-coding RNAs in MCL pathobiology with perspectives for clinical use. |
| first_indexed | 2024-03-10T08:10:15Z |
| format | Article |
| id | doaj.art-e74febab22ac4050ac1da041cb3f9605 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:10:15Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e74febab22ac4050ac1da041cb3f96052023-11-22T10:44:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012217949010.3390/ijms22179490Non-Coding RNAs in Normal B-Cell Development and in Mantle Cell Lymphoma: From Molecular Mechanism to Biomarker and Therapeutic Agent PotentialOlga Kersy0Mali Salmon-Divon1Ofer Shpilberg2Oshrat Hershkovitz-Rokah3Department of Molecular Biology, Faculty of Natural Sciences, Ariel University, Ariel 40700, IsraelDepartment of Molecular Biology, Faculty of Natural Sciences, Ariel University, Ariel 40700, IsraelTranslational Research Lab, Assuta Medical Centers, Tel-Aviv 6971028, IsraelDepartment of Molecular Biology, Faculty of Natural Sciences, Ariel University, Ariel 40700, IsraelB-lymphocytes are essential for an efficient immune response against a variety of pathogens. A large fraction of hematologic malignancies are of B-cell origin, suggesting that the development and activation of B cells must be tightly regulated. In recent years, differentially expressed non-coding RNAs have been identified in mantle cell lymphoma (MCL) tumor samples as opposed to their naive, normal B-cell compartment. These aberrantly expressed molecules, specifically microRNAs (miRNAs), circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs), have a role in cellular growth and survival pathways in various biological models. Here, we provide an overview of current knowledge on the role of non-coding RNAs and their relevant targets in B-cell development, activation and malignant transformation, summarizing the current understanding of the role of aberrant expression of non-coding RNAs in MCL pathobiology with perspectives for clinical use.https://www.mdpi.com/1422-0067/22/17/9490microRNAcircRNAlncRNAB-cell lymphomamantle cell lymphoma |
| spellingShingle | Olga Kersy Mali Salmon-Divon Ofer Shpilberg Oshrat Hershkovitz-Rokah Non-Coding RNAs in Normal B-Cell Development and in Mantle Cell Lymphoma: From Molecular Mechanism to Biomarker and Therapeutic Agent Potential International Journal of Molecular Sciences microRNA circRNA lncRNA B-cell lymphoma mantle cell lymphoma |
| title | Non-Coding RNAs in Normal B-Cell Development and in Mantle Cell Lymphoma: From Molecular Mechanism to Biomarker and Therapeutic Agent Potential |
| title_full | Non-Coding RNAs in Normal B-Cell Development and in Mantle Cell Lymphoma: From Molecular Mechanism to Biomarker and Therapeutic Agent Potential |
| title_fullStr | Non-Coding RNAs in Normal B-Cell Development and in Mantle Cell Lymphoma: From Molecular Mechanism to Biomarker and Therapeutic Agent Potential |
| title_full_unstemmed | Non-Coding RNAs in Normal B-Cell Development and in Mantle Cell Lymphoma: From Molecular Mechanism to Biomarker and Therapeutic Agent Potential |
| title_short | Non-Coding RNAs in Normal B-Cell Development and in Mantle Cell Lymphoma: From Molecular Mechanism to Biomarker and Therapeutic Agent Potential |
| title_sort | non coding rnas in normal b cell development and in mantle cell lymphoma from molecular mechanism to biomarker and therapeutic agent potential |
| topic | microRNA circRNA lncRNA B-cell lymphoma mantle cell lymphoma |
| url | https://www.mdpi.com/1422-0067/22/17/9490 |
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