Potential causal associations between leisure sedentary behaviors, physical activity, sleep traits, and myopia: a Mendelian randomization study
Abstract Background Myopia is the most prevalent refractive error and a growing global health concern that significantly affects visual function. Researchers have recently emphasized considerably on the influence of lifestyle on myopia incidence and development. This study investigates the relations...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-024-03367-z |
| _version_ | 1797275450868760576 |
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| author | Xiao-Bin Zhang He-He Jiang Lin-Lin Zhang Chun-Jing Li Chen Chen Meng-Zhen Xing Yu-Ning Ma Yu-Xia Ma |
| author_facet | Xiao-Bin Zhang He-He Jiang Lin-Lin Zhang Chun-Jing Li Chen Chen Meng-Zhen Xing Yu-Ning Ma Yu-Xia Ma |
| author_sort | Xiao-Bin Zhang |
| collection | DOAJ |
| description | Abstract Background Myopia is the most prevalent refractive error and a growing global health concern that significantly affects visual function. Researchers have recently emphasized considerably on the influence of lifestyle on myopia incidence and development. This study investigates the relationship between leisure sedentary behaviors (LSB)/physical activity (PA)/sleep traits and myopia. Methods LSB, PA, and sleep trait-associated genetic variants were used as instrument variables in a Mendelian randomization (MR) study to examine their causal effects on myopia. Summary genome-wide association studies (GWASs) statistical data for LSB and PA were obtained from UK Biobank, and the data of sleep traits was obtained from UK Biobank, UK Biobank and 23andMe, and FinnGen. We used summary statistics data for myopia from MRC IEU. The MR analyses was performed using the inverse variance-weighted (IVW), MR-Egger, weighted median, and MR Pleiotropy RESidual Sum and Outlier methods. Results Computer use was genetically predicted to increase the myopia risk [IVW odds ratio (OR) = 1.057; 95% confidence interval (CI), 1.038–1.078; P = 7.04 × 10− 9]. The self-reported moderate-to-vigorous physical activity (MVPA) (IVW OR = 0.962; 95% CI, 0.932–0.993; P = 1.57 × 10− 2) and television watching (IVW OR = 0.973; 95% CI, 0.961–0.985, P = 1.93 × 10− 5) were significantly associated with a lower myopia risk. However, genetically predicted sleep traits or accelerometer-measured physical activity had no significant associations with myopia. Conclusion Our results indicated that computer use is a risk factor for myopia, whereas television watching and MVPA may protect against myopia. These findings shed new light on possible strategies for reducing the prevalence of myopia. |
| first_indexed | 2024-03-07T15:14:32Z |
| format | Article |
| id | doaj.art-e7521539c5d94611b6dd18e33434b824 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-03-07T15:14:32Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-e7521539c5d94611b6dd18e33434b8242024-03-05T18:02:42ZengBMCBMC Ophthalmology1471-24152024-03-0124111010.1186/s12886-024-03367-zPotential causal associations between leisure sedentary behaviors, physical activity, sleep traits, and myopia: a Mendelian randomization studyXiao-Bin Zhang0He-He Jiang1Lin-Lin Zhang2Chun-Jing Li3Chen Chen4Meng-Zhen Xing5Yu-Ning Ma6Yu-Xia Ma7Shandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineAbstract Background Myopia is the most prevalent refractive error and a growing global health concern that significantly affects visual function. Researchers have recently emphasized considerably on the influence of lifestyle on myopia incidence and development. This study investigates the relationship between leisure sedentary behaviors (LSB)/physical activity (PA)/sleep traits and myopia. Methods LSB, PA, and sleep trait-associated genetic variants were used as instrument variables in a Mendelian randomization (MR) study to examine their causal effects on myopia. Summary genome-wide association studies (GWASs) statistical data for LSB and PA were obtained from UK Biobank, and the data of sleep traits was obtained from UK Biobank, UK Biobank and 23andMe, and FinnGen. We used summary statistics data for myopia from MRC IEU. The MR analyses was performed using the inverse variance-weighted (IVW), MR-Egger, weighted median, and MR Pleiotropy RESidual Sum and Outlier methods. Results Computer use was genetically predicted to increase the myopia risk [IVW odds ratio (OR) = 1.057; 95% confidence interval (CI), 1.038–1.078; P = 7.04 × 10− 9]. The self-reported moderate-to-vigorous physical activity (MVPA) (IVW OR = 0.962; 95% CI, 0.932–0.993; P = 1.57 × 10− 2) and television watching (IVW OR = 0.973; 95% CI, 0.961–0.985, P = 1.93 × 10− 5) were significantly associated with a lower myopia risk. However, genetically predicted sleep traits or accelerometer-measured physical activity had no significant associations with myopia. Conclusion Our results indicated that computer use is a risk factor for myopia, whereas television watching and MVPA may protect against myopia. These findings shed new light on possible strategies for reducing the prevalence of myopia.https://doi.org/10.1186/s12886-024-03367-zCausal relationshipMyopiaLeisure sedentary behaviorsPhysical activitySleep traitsMendelian randomization analysis |
| spellingShingle | Xiao-Bin Zhang He-He Jiang Lin-Lin Zhang Chun-Jing Li Chen Chen Meng-Zhen Xing Yu-Ning Ma Yu-Xia Ma Potential causal associations between leisure sedentary behaviors, physical activity, sleep traits, and myopia: a Mendelian randomization study BMC Ophthalmology Causal relationship Myopia Leisure sedentary behaviors Physical activity Sleep traits Mendelian randomization analysis |
| title | Potential causal associations between leisure sedentary behaviors, physical activity, sleep traits, and myopia: a Mendelian randomization study |
| title_full | Potential causal associations between leisure sedentary behaviors, physical activity, sleep traits, and myopia: a Mendelian randomization study |
| title_fullStr | Potential causal associations between leisure sedentary behaviors, physical activity, sleep traits, and myopia: a Mendelian randomization study |
| title_full_unstemmed | Potential causal associations between leisure sedentary behaviors, physical activity, sleep traits, and myopia: a Mendelian randomization study |
| title_short | Potential causal associations between leisure sedentary behaviors, physical activity, sleep traits, and myopia: a Mendelian randomization study |
| title_sort | potential causal associations between leisure sedentary behaviors physical activity sleep traits and myopia a mendelian randomization study |
| topic | Causal relationship Myopia Leisure sedentary behaviors Physical activity Sleep traits Mendelian randomization analysis |
| url | https://doi.org/10.1186/s12886-024-03367-z |
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