Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing
Topical drug delivery is widely used in various diseases because of the advantages of not passing through the gastrointestinal tract, avoiding gastrointestinal irritation and hepatic first-pass effect, and reaching the lesion directly to reduce unnecessary adverse reactions. The skin helps the organ...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1333986/full |
| _version_ | 1797354463044829184 |
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| author | Lin Zhao Lin Zhao Jiamei Chen Jiamei Chen Bai Bai Bai Bai Guili Song Guili Song Jingwen Zhang Jingwen Zhang Han Yu Han Yu Shiwei Huang Shiwei Huang Zhang Wang Zhang Wang Guanghua Lu Guanghua Lu Guanghua Lu |
| author_facet | Lin Zhao Lin Zhao Jiamei Chen Jiamei Chen Bai Bai Bai Bai Guili Song Guili Song Jingwen Zhang Jingwen Zhang Han Yu Han Yu Shiwei Huang Shiwei Huang Zhang Wang Zhang Wang Guanghua Lu Guanghua Lu Guanghua Lu |
| author_sort | Lin Zhao |
| collection | DOAJ |
| description | Topical drug delivery is widely used in various diseases because of the advantages of not passing through the gastrointestinal tract, avoiding gastrointestinal irritation and hepatic first-pass effect, and reaching the lesion directly to reduce unnecessary adverse reactions. The skin helps the organism to defend itself against a huge majority of external aggressions and is one of the most important lines of defense of the body. However, the skin’s strong barrier ability is also a huge obstacle to the effectiveness of topical medications. Allowing the bioactive, composition in a drug to pass through the stratum corneum barrier as needed to reach the target site is the most essential need for the bioactive, composition to exert its therapeutic effect. The state of the skin barrier, the choice of delivery system for the bioactive, composition, and individualized disease detection and dosing planning influence the effectiveness of topical medications. Nowadays, enhancing transdermal absorption of topically applied drugs is the hottest research area. However, enhancing transdermal absorption of drugs is not the first choice to improve the effectiveness of all drugs. Excessive transdermal absorption enhances topical drug accumulation at non-target sites and the occurrence of adverse reactions. This paper introduces topical drug delivery strategies to improve drug effectiveness from three perspectives: skin barrier, drug delivery system and individualized drug delivery, describes the current status and shortcomings of topical drug research, and provides new directions and ideas for topical drug research. |
| first_indexed | 2024-03-08T13:50:45Z |
| format | Article |
| id | doaj.art-e752b1ea6aeb499299afd906e9a9b4ac |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T13:50:45Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-e752b1ea6aeb499299afd906e9a9b4ac2024-01-16T04:42:19ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-01-011410.3389/fphar.2023.13339861333986Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosingLin Zhao0Lin Zhao1Jiamei Chen2Jiamei Chen3Bai Bai4Bai Bai5Guili Song6Guili Song7Jingwen Zhang8Jingwen Zhang9Han Yu10Han Yu11Shiwei Huang12Shiwei Huang13Zhang Wang14Zhang Wang15Guanghua Lu16Guanghua Lu17Guanghua Lu18State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaTopical drug delivery is widely used in various diseases because of the advantages of not passing through the gastrointestinal tract, avoiding gastrointestinal irritation and hepatic first-pass effect, and reaching the lesion directly to reduce unnecessary adverse reactions. The skin helps the organism to defend itself against a huge majority of external aggressions and is one of the most important lines of defense of the body. However, the skin’s strong barrier ability is also a huge obstacle to the effectiveness of topical medications. Allowing the bioactive, composition in a drug to pass through the stratum corneum barrier as needed to reach the target site is the most essential need for the bioactive, composition to exert its therapeutic effect. The state of the skin barrier, the choice of delivery system for the bioactive, composition, and individualized disease detection and dosing planning influence the effectiveness of topical medications. Nowadays, enhancing transdermal absorption of topically applied drugs is the hottest research area. However, enhancing transdermal absorption of drugs is not the first choice to improve the effectiveness of all drugs. Excessive transdermal absorption enhances topical drug accumulation at non-target sites and the occurrence of adverse reactions. This paper introduces topical drug delivery strategies to improve drug effectiveness from three perspectives: skin barrier, drug delivery system and individualized drug delivery, describes the current status and shortcomings of topical drug research, and provides new directions and ideas for topical drug research.https://www.frontiersin.org/articles/10.3389/fphar.2023.1333986/fulltopical drugdrug effectivenessskin barriersindividualized dosingdrug delivery |
| spellingShingle | Lin Zhao Lin Zhao Jiamei Chen Jiamei Chen Bai Bai Bai Bai Guili Song Guili Song Jingwen Zhang Jingwen Zhang Han Yu Han Yu Shiwei Huang Shiwei Huang Zhang Wang Zhang Wang Guanghua Lu Guanghua Lu Guanghua Lu Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing Frontiers in Pharmacology topical drug drug effectiveness skin barriers individualized dosing drug delivery |
| title | Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing |
| title_full | Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing |
| title_fullStr | Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing |
| title_full_unstemmed | Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing |
| title_short | Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing |
| title_sort | topical drug delivery strategies for enhancing drug effectiveness by skin barriers drug delivery systems and individualized dosing |
| topic | topical drug drug effectiveness skin barriers individualized dosing drug delivery |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1333986/full |
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