Association of systemic inflammation index with survival in patients with advanced perihilar cholangiocarcinoma treated with interventional therapy
ObjectiveImmunity and inflammation are key mediators of carcinoma development, invasion and metastasis. However, it remains unknown whether the systemic immune-inflammation index (SII) can be used as a prognostic indicator for cholangiocarcinoma. In this study, we investigated the association and pr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1038759/full |
| _version_ | 1797979201580564480 |
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| author | Jinyu Li Long Gao Tianci Liu Duiping Feng |
| author_facet | Jinyu Li Long Gao Tianci Liu Duiping Feng |
| author_sort | Jinyu Li |
| collection | DOAJ |
| description | ObjectiveImmunity and inflammation are key mediators of carcinoma development, invasion and metastasis. However, it remains unknown whether the systemic immune-inflammation index (SII) can be used as a prognostic indicator for cholangiocarcinoma. In this study, we investigated the association and predictive value of the SII with the prognosis of advanced perihilar cholangiocarcinoma (pCCA) after interventional therapy.MethodsA retrospective cohort of patients with advanced pCCA treated with interventional therapy at the First Hospital of Shanxi Medical University enrolled in this study from January 2019 through January 2021 was examined. Cox regression models were used to analyze the relationship between the SII and overall survival (OS) of patients with advanced pCCA. Receiver operating characteristic (ROC) analysis was used to evaluate the predictive power of SII.ResultsPreoperative SII was positively associated with poor OS of pCCA after interventional therapy, with corresponding hazard ratios (HR) of 1.57 (95% CI: 1.17 - 2.10) for an inter-quartile range increase. The predictive power of SII was higher than that of other inflammation indexes based on ROC analysis (AUC = 0.835 [95% CI (0.731 - 0.940)]). The optimal cut-off values, sensitivity, and specificity with SII were 700, 0.774 and 0.846, respectively. An SII ≥ 700 was significantly associated with lymph node metastasis and high carbohydrate antigen199 (CA199) level. In multivariate analyses, total bilirubin, carbohydrate antigen 199, vascular invasion, and SII independently predicted overall survival (P < 0.05).ConclusionThis is the first study demonstrating that an increase in the SII is associated with poor advanced pCCA prognosis, and could serve as a reliable prognostic indicator of pCCA after interventional therapy. |
| first_indexed | 2024-04-11T05:35:15Z |
| format | Article |
| id | doaj.art-e752c1958646414cad5238a7dd62dc88 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T05:35:15Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e752c1958646414cad5238a7dd62dc882022-12-22T13:58:11ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10387591038759Association of systemic inflammation index with survival in patients with advanced perihilar cholangiocarcinoma treated with interventional therapyJinyu Li0Long Gao1Tianci Liu2Duiping Feng3Department of Oncological and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Oncological and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, ChinaCollege of Medical Imaging, Shanxi Medical University, Taiyuan, ChinaDepartment of Oncological and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, ChinaObjectiveImmunity and inflammation are key mediators of carcinoma development, invasion and metastasis. However, it remains unknown whether the systemic immune-inflammation index (SII) can be used as a prognostic indicator for cholangiocarcinoma. In this study, we investigated the association and predictive value of the SII with the prognosis of advanced perihilar cholangiocarcinoma (pCCA) after interventional therapy.MethodsA retrospective cohort of patients with advanced pCCA treated with interventional therapy at the First Hospital of Shanxi Medical University enrolled in this study from January 2019 through January 2021 was examined. Cox regression models were used to analyze the relationship between the SII and overall survival (OS) of patients with advanced pCCA. Receiver operating characteristic (ROC) analysis was used to evaluate the predictive power of SII.ResultsPreoperative SII was positively associated with poor OS of pCCA after interventional therapy, with corresponding hazard ratios (HR) of 1.57 (95% CI: 1.17 - 2.10) for an inter-quartile range increase. The predictive power of SII was higher than that of other inflammation indexes based on ROC analysis (AUC = 0.835 [95% CI (0.731 - 0.940)]). The optimal cut-off values, sensitivity, and specificity with SII were 700, 0.774 and 0.846, respectively. An SII ≥ 700 was significantly associated with lymph node metastasis and high carbohydrate antigen199 (CA199) level. In multivariate analyses, total bilirubin, carbohydrate antigen 199, vascular invasion, and SII independently predicted overall survival (P < 0.05).ConclusionThis is the first study demonstrating that an increase in the SII is associated with poor advanced pCCA prognosis, and could serve as a reliable prognostic indicator of pCCA after interventional therapy.https://www.frontiersin.org/articles/10.3389/fonc.2022.1038759/fulladvanced perihilar cholangiocarcinomasystemic immune-inflammation indexoverall survivalprognosisinterventional therapy |
| spellingShingle | Jinyu Li Long Gao Tianci Liu Duiping Feng Association of systemic inflammation index with survival in patients with advanced perihilar cholangiocarcinoma treated with interventional therapy Frontiers in Oncology advanced perihilar cholangiocarcinoma systemic immune-inflammation index overall survival prognosis interventional therapy |
| title | Association of systemic inflammation index with survival in patients with advanced perihilar cholangiocarcinoma treated with interventional therapy |
| title_full | Association of systemic inflammation index with survival in patients with advanced perihilar cholangiocarcinoma treated with interventional therapy |
| title_fullStr | Association of systemic inflammation index with survival in patients with advanced perihilar cholangiocarcinoma treated with interventional therapy |
| title_full_unstemmed | Association of systemic inflammation index with survival in patients with advanced perihilar cholangiocarcinoma treated with interventional therapy |
| title_short | Association of systemic inflammation index with survival in patients with advanced perihilar cholangiocarcinoma treated with interventional therapy |
| title_sort | association of systemic inflammation index with survival in patients with advanced perihilar cholangiocarcinoma treated with interventional therapy |
| topic | advanced perihilar cholangiocarcinoma systemic immune-inflammation index overall survival prognosis interventional therapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1038759/full |
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