Seneca Valley virus 3Cpro antagonizes host innate immune responses and programmed cell death
Seneca Valley virus (SVV), a member of the Picornaviridae family, may cause serious water blister diseases in pregnant sows and acute death in newborn piglets, which have resulted in economic losses in pig production. The 3C protease is a vital enzyme for SVV maturation and is capable of regulating...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1235620/full |
| _version_ | 1797665300742668288 |
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| author | Xin-yu Zhang Yu-ying Li Hai-xin Huang Hai-xin Huang Chen-chen Zhao Xiao-xiao Lei Bao-peng Zhao Jing-yi Lu Tian Lan Wen-chao Sun |
| author_facet | Xin-yu Zhang Yu-ying Li Hai-xin Huang Hai-xin Huang Chen-chen Zhao Xiao-xiao Lei Bao-peng Zhao Jing-yi Lu Tian Lan Wen-chao Sun |
| author_sort | Xin-yu Zhang |
| collection | DOAJ |
| description | Seneca Valley virus (SVV), a member of the Picornaviridae family, may cause serious water blister diseases in pregnant sows and acute death in newborn piglets, which have resulted in economic losses in pig production. The 3C protease is a vital enzyme for SVV maturation and is capable of regulating protein cleavage and RNA replication of the virus. Additionally, this protease can impede the host’s innate immune response by targeting the interferon pathway’s principal factor and enhance virus replication by modulating the host’s RNA metabolism while simultaneously triggering programmed cell death. This article reviews recent studies on SVV 3C functions, which include viral replication promotion, cell apoptosis modulation and host immune response evasion, and provides a theoretical basis for research on preventing and controlling SVV infection. |
| first_indexed | 2024-03-11T19:41:59Z |
| format | Article |
| id | doaj.art-e7550839bd3e423c8e2845cd8baf2594 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-11T19:41:59Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-e7550839bd3e423c8e2845cd8baf25942023-10-06T09:59:05ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-10-011410.3389/fmicb.2023.12356201235620Seneca Valley virus 3Cpro antagonizes host innate immune responses and programmed cell deathXin-yu Zhang0Yu-ying Li1Hai-xin Huang2Hai-xin Huang3Chen-chen Zhao4Xiao-xiao Lei5Bao-peng Zhao6Jing-yi Lu7Tian Lan8Wen-chao Sun9Institute of Virology, Wenzhou University, Wenzhou, ChinaInstitute of Virology, Wenzhou University, Wenzhou, ChinaInstitute of Virology, Wenzhou University, Wenzhou, ChinaCollege of Veterinary Medicine, Northwest A&F University, Xianyang, ChinaInstitute of Virology, Wenzhou University, Wenzhou, ChinaInstitute of Virology, Wenzhou University, Wenzhou, ChinaInstitute of Virology, Wenzhou University, Wenzhou, ChinaInstitute of Virology, Wenzhou University, Wenzhou, ChinaInstitute of Virology, Wenzhou University, Wenzhou, ChinaInstitute of Virology, Wenzhou University, Wenzhou, ChinaSeneca Valley virus (SVV), a member of the Picornaviridae family, may cause serious water blister diseases in pregnant sows and acute death in newborn piglets, which have resulted in economic losses in pig production. The 3C protease is a vital enzyme for SVV maturation and is capable of regulating protein cleavage and RNA replication of the virus. Additionally, this protease can impede the host’s innate immune response by targeting the interferon pathway’s principal factor and enhance virus replication by modulating the host’s RNA metabolism while simultaneously triggering programmed cell death. This article reviews recent studies on SVV 3C functions, which include viral replication promotion, cell apoptosis modulation and host immune response evasion, and provides a theoretical basis for research on preventing and controlling SVV infection.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1235620/full3C proteasevirus replicationinterferon pathwayhost RNA metabolismprogrammed cell death |
| spellingShingle | Xin-yu Zhang Yu-ying Li Hai-xin Huang Hai-xin Huang Chen-chen Zhao Xiao-xiao Lei Bao-peng Zhao Jing-yi Lu Tian Lan Wen-chao Sun Seneca Valley virus 3Cpro antagonizes host innate immune responses and programmed cell death Frontiers in Microbiology 3C protease virus replication interferon pathway host RNA metabolism programmed cell death |
| title | Seneca Valley virus 3Cpro antagonizes host innate immune responses and programmed cell death |
| title_full | Seneca Valley virus 3Cpro antagonizes host innate immune responses and programmed cell death |
| title_fullStr | Seneca Valley virus 3Cpro antagonizes host innate immune responses and programmed cell death |
| title_full_unstemmed | Seneca Valley virus 3Cpro antagonizes host innate immune responses and programmed cell death |
| title_short | Seneca Valley virus 3Cpro antagonizes host innate immune responses and programmed cell death |
| title_sort | seneca valley virus 3cpro antagonizes host innate immune responses and programmed cell death |
| topic | 3C protease virus replication interferon pathway host RNA metabolism programmed cell death |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1235620/full |
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