Recent advances in multicellular human liver models
The liver is the most important metabolic organ in the body. Model systems that recapitulate the complex organ structure and cell composition of the human liver are insufficient to study liver biology and to test toxicity and efficacy during new drug development. Recently established 3-dimensional l...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Organoid Society
2022-10-01
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| Series: | Organoid |
| Subjects: | |
| Online Access: | http://j-organoid.org/upload/pdf/organoid-2022-2-e26.pdf |
| _version_ | 1797768377130811392 |
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| author | Seon Ju Mun Jaeseo Lee Yongbo Shin Vincent Eun Youngmi Ji Myung Jin Son |
| author_facet | Seon Ju Mun Jaeseo Lee Yongbo Shin Vincent Eun Youngmi Ji Myung Jin Son |
| author_sort | Seon Ju Mun |
| collection | DOAJ |
| description | The liver is the most important metabolic organ in the body. Model systems that recapitulate the complex organ structure and cell composition of the human liver are insufficient to study liver biology and to test toxicity and efficacy during new drug development. Recently established 3-dimensional liver models, including spheroids and organoids, organs-on-a-chip, bioprinting, and the decellularization/recellularization technique, have provided platforms that emulate the structural and functional characteristics of the human liver better than conventional 2-dimensional cell culture models and animal models. This review summarizes the architecture and cell compositions of human liver tissue, focusing on recent studies of multicellular human liver models that recapitulate in vivo-like physiologies with morphological and functional advances by the cellular communication of parenchymal and non-parenchymal cells. We discuss the applications, limitations, and future perspectives of advanced multicellular human liver models. |
| first_indexed | 2024-03-12T20:53:37Z |
| format | Article |
| id | doaj.art-e756ca695bdb409db960d4f6eed9862c |
| institution | Directory Open Access Journal |
| issn | 2765-205X |
| language | English |
| last_indexed | 2024-03-12T20:53:37Z |
| publishDate | 2022-10-01 |
| publisher | The Organoid Society |
| record_format | Article |
| series | Organoid |
| spelling | doaj.art-e756ca695bdb409db960d4f6eed9862c2023-08-01T00:42:00ZengThe Organoid SocietyOrganoid2765-205X2022-10-01210.51335/organoid.2022.2.e2639Recent advances in multicellular human liver modelsSeon Ju Mun0Jaeseo Lee1Yongbo Shin2Vincent Eun3Youngmi Ji4Myung Jin Son5 Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, KoreaThe liver is the most important metabolic organ in the body. Model systems that recapitulate the complex organ structure and cell composition of the human liver are insufficient to study liver biology and to test toxicity and efficacy during new drug development. Recently established 3-dimensional liver models, including spheroids and organoids, organs-on-a-chip, bioprinting, and the decellularization/recellularization technique, have provided platforms that emulate the structural and functional characteristics of the human liver better than conventional 2-dimensional cell culture models and animal models. This review summarizes the architecture and cell compositions of human liver tissue, focusing on recent studies of multicellular human liver models that recapitulate in vivo-like physiologies with morphological and functional advances by the cellular communication of parenchymal and non-parenchymal cells. We discuss the applications, limitations, and future perspectives of advanced multicellular human liver models.http://j-organoid.org/upload/pdf/organoid-2022-2-e26.pdfliverorganoidscoculture techniquestissue engineeringgrowth & development |
| spellingShingle | Seon Ju Mun Jaeseo Lee Yongbo Shin Vincent Eun Youngmi Ji Myung Jin Son Recent advances in multicellular human liver models Organoid liver organoids coculture techniques tissue engineering growth & development |
| title | Recent advances in multicellular human liver models |
| title_full | Recent advances in multicellular human liver models |
| title_fullStr | Recent advances in multicellular human liver models |
| title_full_unstemmed | Recent advances in multicellular human liver models |
| title_short | Recent advances in multicellular human liver models |
| title_sort | recent advances in multicellular human liver models |
| topic | liver organoids coculture techniques tissue engineering growth & development |
| url | http://j-organoid.org/upload/pdf/organoid-2022-2-e26.pdf |
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