Precision Nutrition in Chronic Inflammation
The molecular foundation of chronic inflammatory diseases (CIDs) can differ markedly between individuals. As our understanding of the biochemical mechanisms underlying individual disease manifestations and progressions expands, new strategies to adjust treatments to the patient’s characteristics wil...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-11-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.587895/full |
| _version_ | 1828781910853156864 |
|---|---|
| author | Tobias J. Demetrowitsch Kristina Schlicht Carina Knappe Johannes Zimmermann Julia Jensen-Kroll Alina Pisarevskaja Alina Pisarevskaja Fynn Brix Juliane Brandes Corinna Geisler Georgios Marinos Felix Sommer Dominik M. Schulte Christoph Kaleta Vibeke Andersen Vibeke Andersen Vibeke Andersen Matthias Laudes Karin Schwarz Silvio Waschina |
| author_facet | Tobias J. Demetrowitsch Kristina Schlicht Carina Knappe Johannes Zimmermann Julia Jensen-Kroll Alina Pisarevskaja Alina Pisarevskaja Fynn Brix Juliane Brandes Corinna Geisler Georgios Marinos Felix Sommer Dominik M. Schulte Christoph Kaleta Vibeke Andersen Vibeke Andersen Vibeke Andersen Matthias Laudes Karin Schwarz Silvio Waschina |
| author_sort | Tobias J. Demetrowitsch |
| collection | DOAJ |
| description | The molecular foundation of chronic inflammatory diseases (CIDs) can differ markedly between individuals. As our understanding of the biochemical mechanisms underlying individual disease manifestations and progressions expands, new strategies to adjust treatments to the patient’s characteristics will continue to profoundly transform clinical practice. Nutrition has long been recognized as an important determinant of inflammatory disease phenotypes and treatment response. Yet empirical work demonstrating the therapeutic effectiveness of patient-tailored nutrition remains scarce. This is mainly due to the challenges presented by long-term effects of nutrition, variations in inter-individual gastrointestinal microbiota, the multiplicity of human metabolic pathways potentially affected by food ingredients, nutrition behavior, and the complexity of food composition. Historically, these challenges have been addressed in both human studies and experimental model laboratory studies primarily by using individual nutrition data collection in tandem with large-scale biomolecular data acquisition (e.g. genomics, metabolomics, etc.). This review highlights recent findings in the field of precision nutrition and their potential implications for the development of personalized treatment strategies for CIDs. It emphasizes the importance of computational approaches to integrate nutritional information into multi-omics data analysis and to predict which molecular mechanisms may explain how nutrients intersect with disease pathways. We conclude that recent findings point towards the unexhausted potential of nutrition as part of personalized medicine in chronic inflammation. |
| first_indexed | 2024-12-11T17:40:38Z |
| format | Article |
| id | doaj.art-e7580eeb59c64479aceec409083328e8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T17:40:38Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e7580eeb59c64479aceec409083328e82022-12-22T00:56:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-11-011110.3389/fimmu.2020.587895587895Precision Nutrition in Chronic InflammationTobias J. Demetrowitsch0Kristina Schlicht1Carina Knappe2Johannes Zimmermann3Julia Jensen-Kroll4Alina Pisarevskaja5Alina Pisarevskaja6Fynn Brix7Juliane Brandes8Corinna Geisler9Georgios Marinos10Felix Sommer11Dominik M. Schulte12Christoph Kaleta13Vibeke Andersen14Vibeke Andersen15Vibeke Andersen16Matthias Laudes17Karin Schwarz18Silvio Waschina19Division of Food Technology, Institute of Human Nutrition and Food Science, Kiel University, Kiel, GermanyDivision of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine 1, Kiel University, Kiel, GermanyDivision of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine 1, Kiel University, Kiel, GermanyResearch Group Medical Systems Biology, Institute of Experimental Medicine, Kiel University, Kiel, GermanyDivision of Food Technology, Institute of Human Nutrition and Food Science, Kiel University, Kiel, GermanyDivision of Food Technology, Institute of Human Nutrition and Food Science, Kiel University, Kiel, GermanyDivision of Nutriinformatics, Institute of Human Nutrition and Food Science, Kiel University, Kiel, GermanyDivision of Food Technology, Institute of Human Nutrition and Food Science, Kiel University, Kiel, GermanyDivision of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine 1, Kiel University, Kiel, GermanyDivision of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine 1, Kiel University, Kiel, GermanyResearch Group Medical Systems Biology, Institute of Experimental Medicine, Kiel University, Kiel, GermanyInstitute of Clinical Molecular Biology (IKMB), Kiel University, Kiel, GermanyDivision of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine 1, Kiel University, Kiel, GermanyResearch Group Medical Systems Biology, Institute of Experimental Medicine, Kiel University, Kiel, GermanyInstitute of Regional Research, University of Southern Denmark, Odense, DenmarkInstitute of Molecular Medicine, University of Southern Denmark, Odense, DenmarkFocused Research Unit for Molecular Diagnostic and Clinical Research, University Hospital of Southern Denmark, Aabenraa, DenmarkDivision of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine 1, Kiel University, Kiel, GermanyDivision of Food Technology, Institute of Human Nutrition and Food Science, Kiel University, Kiel, GermanyDivision of Nutriinformatics, Institute of Human Nutrition and Food Science, Kiel University, Kiel, GermanyThe molecular foundation of chronic inflammatory diseases (CIDs) can differ markedly between individuals. As our understanding of the biochemical mechanisms underlying individual disease manifestations and progressions expands, new strategies to adjust treatments to the patient’s characteristics will continue to profoundly transform clinical practice. Nutrition has long been recognized as an important determinant of inflammatory disease phenotypes and treatment response. Yet empirical work demonstrating the therapeutic effectiveness of patient-tailored nutrition remains scarce. This is mainly due to the challenges presented by long-term effects of nutrition, variations in inter-individual gastrointestinal microbiota, the multiplicity of human metabolic pathways potentially affected by food ingredients, nutrition behavior, and the complexity of food composition. Historically, these challenges have been addressed in both human studies and experimental model laboratory studies primarily by using individual nutrition data collection in tandem with large-scale biomolecular data acquisition (e.g. genomics, metabolomics, etc.). This review highlights recent findings in the field of precision nutrition and their potential implications for the development of personalized treatment strategies for CIDs. It emphasizes the importance of computational approaches to integrate nutritional information into multi-omics data analysis and to predict which molecular mechanisms may explain how nutrients intersect with disease pathways. We conclude that recent findings point towards the unexhausted potential of nutrition as part of personalized medicine in chronic inflammation.https://www.frontiersin.org/articles/10.3389/fimmu.2020.587895/fullnutritionpersonalized medicineinflammationdietary interventiondisease preventionmicrobiota |
| spellingShingle | Tobias J. Demetrowitsch Kristina Schlicht Carina Knappe Johannes Zimmermann Julia Jensen-Kroll Alina Pisarevskaja Alina Pisarevskaja Fynn Brix Juliane Brandes Corinna Geisler Georgios Marinos Felix Sommer Dominik M. Schulte Christoph Kaleta Vibeke Andersen Vibeke Andersen Vibeke Andersen Matthias Laudes Karin Schwarz Silvio Waschina Precision Nutrition in Chronic Inflammation Frontiers in Immunology nutrition personalized medicine inflammation dietary intervention disease prevention microbiota |
| title | Precision Nutrition in Chronic Inflammation |
| title_full | Precision Nutrition in Chronic Inflammation |
| title_fullStr | Precision Nutrition in Chronic Inflammation |
| title_full_unstemmed | Precision Nutrition in Chronic Inflammation |
| title_short | Precision Nutrition in Chronic Inflammation |
| title_sort | precision nutrition in chronic inflammation |
| topic | nutrition personalized medicine inflammation dietary intervention disease prevention microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.587895/full |
| work_keys_str_mv | AT tobiasjdemetrowitsch precisionnutritioninchronicinflammation AT kristinaschlicht precisionnutritioninchronicinflammation AT carinaknappe precisionnutritioninchronicinflammation AT johanneszimmermann precisionnutritioninchronicinflammation AT juliajensenkroll precisionnutritioninchronicinflammation AT alinapisarevskaja precisionnutritioninchronicinflammation AT alinapisarevskaja precisionnutritioninchronicinflammation AT fynnbrix precisionnutritioninchronicinflammation AT julianebrandes precisionnutritioninchronicinflammation AT corinnageisler precisionnutritioninchronicinflammation AT georgiosmarinos precisionnutritioninchronicinflammation AT felixsommer precisionnutritioninchronicinflammation AT dominikmschulte precisionnutritioninchronicinflammation AT christophkaleta precisionnutritioninchronicinflammation AT vibekeandersen precisionnutritioninchronicinflammation AT vibekeandersen precisionnutritioninchronicinflammation AT vibekeandersen precisionnutritioninchronicinflammation AT matthiaslaudes precisionnutritioninchronicinflammation AT karinschwarz precisionnutritioninchronicinflammation AT silviowaschina precisionnutritioninchronicinflammation |