Inhibition of the Niemann-Pick C1 protein is a conserved feature of multiple strains of pathogenic mycobacteria
Lipids shed by pathogenic mycobacteria have been shown to inhibit NPC1, a lysosomal membrane protein deficient in most cases of a rate inherited lysosomal storage disorder Niemann-Pick disease type C (NPC). Here, authors utilise lipid extracts from clinical Mycobacterium tuberculosis strains, and no...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32553-0 |
| _version_ | 1811273519161409536 |
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| author | Yuzhe Weng Dawn Shepherd Yi Liu Nitya Krishnan Brian D. Robertson Nick Platt Gerald Larrouy-Maumus Frances M. Platt |
| author_facet | Yuzhe Weng Dawn Shepherd Yi Liu Nitya Krishnan Brian D. Robertson Nick Platt Gerald Larrouy-Maumus Frances M. Platt |
| author_sort | Yuzhe Weng |
| collection | DOAJ |
| description | Lipids shed by pathogenic mycobacteria have been shown to inhibit NPC1, a lysosomal membrane protein deficient in most cases of a rate inherited lysosomal storage disorder Niemann-Pick disease type C (NPC). Here, authors utilise lipid extracts from clinical Mycobacterium tuberculosis strains, and non-tubercular mycobacteria to investigate their ability to inhibit the NPC pathway. |
| first_indexed | 2024-04-12T23:01:48Z |
| format | Article |
| id | doaj.art-e759a16f0ebe4d9e872a5202002ab985 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T23:01:48Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e759a16f0ebe4d9e872a5202002ab9852022-12-22T03:13:03ZengNature PortfolioNature Communications2041-17232022-09-0113111610.1038/s41467-022-32553-0Inhibition of the Niemann-Pick C1 protein is a conserved feature of multiple strains of pathogenic mycobacteriaYuzhe Weng0Dawn Shepherd1Yi Liu2Nitya Krishnan3Brian D. Robertson4Nick Platt5Gerald Larrouy-Maumus6Frances M. Platt7Department of Pharmacology, University of OxfordDepartment of Pharmacology, University of OxfordMRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Faculty of Natural Sciences, Imperial College LondonMRC Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College LondonMRC Centre for Molecular Bacteriology and Infection, Department of Infectious Disease, Imperial College LondonDepartment of Pharmacology, University of OxfordMRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Faculty of Natural Sciences, Imperial College LondonDepartment of Pharmacology, University of OxfordLipids shed by pathogenic mycobacteria have been shown to inhibit NPC1, a lysosomal membrane protein deficient in most cases of a rate inherited lysosomal storage disorder Niemann-Pick disease type C (NPC). Here, authors utilise lipid extracts from clinical Mycobacterium tuberculosis strains, and non-tubercular mycobacteria to investigate their ability to inhibit the NPC pathway.https://doi.org/10.1038/s41467-022-32553-0 |
| spellingShingle | Yuzhe Weng Dawn Shepherd Yi Liu Nitya Krishnan Brian D. Robertson Nick Platt Gerald Larrouy-Maumus Frances M. Platt Inhibition of the Niemann-Pick C1 protein is a conserved feature of multiple strains of pathogenic mycobacteria Nature Communications |
| title | Inhibition of the Niemann-Pick C1 protein is a conserved feature of multiple strains of pathogenic mycobacteria |
| title_full | Inhibition of the Niemann-Pick C1 protein is a conserved feature of multiple strains of pathogenic mycobacteria |
| title_fullStr | Inhibition of the Niemann-Pick C1 protein is a conserved feature of multiple strains of pathogenic mycobacteria |
| title_full_unstemmed | Inhibition of the Niemann-Pick C1 protein is a conserved feature of multiple strains of pathogenic mycobacteria |
| title_short | Inhibition of the Niemann-Pick C1 protein is a conserved feature of multiple strains of pathogenic mycobacteria |
| title_sort | inhibition of the niemann pick c1 protein is a conserved feature of multiple strains of pathogenic mycobacteria |
| url | https://doi.org/10.1038/s41467-022-32553-0 |
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