Unveiling the therapeutic potential of cabozantinib-loaded poly D,L-lactic-co-glycolic acid and polysarcosine nanoparticles in inducing apoptosis and cytotoxicity in human HepG2 hepatocellular carcinoma cell lines and in vivo anti-tumor activity in SCID female mice

Unveiling the therapeutic potential of cabozantinib-loaded poly D,L-lactic-co-glycolic acid and polysarcosine nanoparticles in inducing apoptosis and cytotoxicity in human HepG2 hepatocellular carcinoma cell lines and in vivo anti-tumor activity in SCID female mice

IntroductionThe study aimed to develop a nano-based drug delivery system for the treatment of hepatocellular carcinoma (HCC), a type of liver cancer that accounts for 90% of all liver malignancies. The study focused on the use of cabozantinib (CNB), a potent multikinase inhibitor that targets the V...

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Bibliographic Details
Main Authors: Sankha Bhattacharya, Vipan Kumar Parihar, Bhupendra G. Prajapati
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Oncology
Subjects:
cabozantinib
polysarcosine
HepG2
flow cytometry
annexin V staining
apoptosis analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1125857/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1125857/full

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