Role of diffusion MRI in diagnosis of mediastinal lymphoma: initial assessment and response to therapy
Abstract Background Malignant lymphoma accounts for nearly 20% of all mediastinal neoplasms in adults and 50% in children. Hodgkin’s disease is the most common primary mediastinal lymphoma. In non-Hodgkin’s lymphoma, the two most common forms of primary mediastinal lymphoma are lymphoblastic lymphom...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-08-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43055-021-00597-9 |
| _version_ | 1818578702890434560 |
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| author | Youssriah Yahia Sabri Nourhan Mohamed Ewis Hussam Eldin Hamdy Zawam Mostafa Ahmed Khairy |
| author_facet | Youssriah Yahia Sabri Nourhan Mohamed Ewis Hussam Eldin Hamdy Zawam Mostafa Ahmed Khairy |
| author_sort | Youssriah Yahia Sabri |
| collection | DOAJ |
| description | Abstract Background Malignant lymphoma accounts for nearly 20% of all mediastinal neoplasms in adults and 50% in children. Hodgkin’s disease is the most common primary mediastinal lymphoma. In non-Hodgkin’s lymphoma, the two most common forms of primary mediastinal lymphoma are lymphoblastic lymphoma and diffuse large B-cell lymphoma. The aim of this study is to implement diffusion MRI in the algorithm of diagnosis of mediastinal lymphoma, differentiating Hodgkin's from non-Hodgkin's lymphoma and assessment of post therapeutic response. Results Using Diffusion weighted magnetic resonance imaging DWI-MRI, there were statistic significant difference between ADC values in lymph nodes and mediastinal masses in Hodgkin and non-Hodgkin lymphomas. ADC range in non-treated Hodgkin lymphoma cases was 0.774 to 1.4, while ADC range in in non-treated non-Hodgkin lymphoma was 0.476 to 0.668. In this study, there was statistically significant difference of ADC values in lymphoma cases presented by mediastinal masses with and without chemotherapy. Conclusions Diffusion weighted magnetic resonance imaging DWI-MRI is a promising functional technique in diagnosis of Hodgkin's and non-Hodgkin's lymphoma and assessment of response to treatment with no need for special preparation, contrast injection or radiation exposure. |
| first_indexed | 2024-12-16T06:50:01Z |
| format | Article |
| id | doaj.art-e75a23eace974f7eaf9b2b0c2f2a313b |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-12-16T06:50:01Z |
| publishDate | 2021-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-e75a23eace974f7eaf9b2b0c2f2a313b2022-12-21T22:40:26ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622021-08-0152111110.1186/s43055-021-00597-9Role of diffusion MRI in diagnosis of mediastinal lymphoma: initial assessment and response to therapyYoussriah Yahia Sabri0Nourhan Mohamed Ewis1Hussam Eldin Hamdy Zawam2Mostafa Ahmed Khairy3Department of Diagnostic and Interventional Radiology, Kasr Al Ainy, Faculty of Medicine, Cairo UniversityDepartment of Diagnostic and Interventional Radiology, Kasr Al Ainy, Faculty of Medicine, Cairo UniversityDepartment of Clinical Oncology, Kasr Al Ainy, Faculty of Medicine, Cairo UniversityDepartment of Diagnostic and Interventional Radiology, Kasr Al Ainy, Faculty of Medicine, Cairo UniversityAbstract Background Malignant lymphoma accounts for nearly 20% of all mediastinal neoplasms in adults and 50% in children. Hodgkin’s disease is the most common primary mediastinal lymphoma. In non-Hodgkin’s lymphoma, the two most common forms of primary mediastinal lymphoma are lymphoblastic lymphoma and diffuse large B-cell lymphoma. The aim of this study is to implement diffusion MRI in the algorithm of diagnosis of mediastinal lymphoma, differentiating Hodgkin's from non-Hodgkin's lymphoma and assessment of post therapeutic response. Results Using Diffusion weighted magnetic resonance imaging DWI-MRI, there were statistic significant difference between ADC values in lymph nodes and mediastinal masses in Hodgkin and non-Hodgkin lymphomas. ADC range in non-treated Hodgkin lymphoma cases was 0.774 to 1.4, while ADC range in in non-treated non-Hodgkin lymphoma was 0.476 to 0.668. In this study, there was statistically significant difference of ADC values in lymphoma cases presented by mediastinal masses with and without chemotherapy. Conclusions Diffusion weighted magnetic resonance imaging DWI-MRI is a promising functional technique in diagnosis of Hodgkin's and non-Hodgkin's lymphoma and assessment of response to treatment with no need for special preparation, contrast injection or radiation exposure.https://doi.org/10.1186/s43055-021-00597-9MediastinumMalignantLymphomaHodgkinNon-HodgkinDiffusion |
| spellingShingle | Youssriah Yahia Sabri Nourhan Mohamed Ewis Hussam Eldin Hamdy Zawam Mostafa Ahmed Khairy Role of diffusion MRI in diagnosis of mediastinal lymphoma: initial assessment and response to therapy The Egyptian Journal of Radiology and Nuclear Medicine Mediastinum Malignant Lymphoma Hodgkin Non-Hodgkin Diffusion |
| title | Role of diffusion MRI in diagnosis of mediastinal lymphoma: initial assessment and response to therapy |
| title_full | Role of diffusion MRI in diagnosis of mediastinal lymphoma: initial assessment and response to therapy |
| title_fullStr | Role of diffusion MRI in diagnosis of mediastinal lymphoma: initial assessment and response to therapy |
| title_full_unstemmed | Role of diffusion MRI in diagnosis of mediastinal lymphoma: initial assessment and response to therapy |
| title_short | Role of diffusion MRI in diagnosis of mediastinal lymphoma: initial assessment and response to therapy |
| title_sort | role of diffusion mri in diagnosis of mediastinal lymphoma initial assessment and response to therapy |
| topic | Mediastinum Malignant Lymphoma Hodgkin Non-Hodgkin Diffusion |
| url | https://doi.org/10.1186/s43055-021-00597-9 |
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