Gut microbiota-modulating agents in alcoholic liver disease: Links between host metabolism and gut microbiota
Alcoholic liver disease (ALD) involves a wide spectrum of diseases, including asymptomatic hepatic steatosis, alcoholic hepatitis, hepatic fibrosis, and cirrhosis, which leads to morbidity and mortality and is responsible for 0.9% of global deaths. Alcohol consumption induces bacterial translocation...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.913842/full |
| _version_ | 1818471492804935680 |
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| author | Jang Han Jung Sung-Eun Kim Sung-Eun Kim Ki Tae Suk Ki Tae Suk Dong Joon Kim Dong Joon Kim |
| author_facet | Jang Han Jung Sung-Eun Kim Sung-Eun Kim Ki Tae Suk Ki Tae Suk Dong Joon Kim Dong Joon Kim |
| author_sort | Jang Han Jung |
| collection | DOAJ |
| description | Alcoholic liver disease (ALD) involves a wide spectrum of diseases, including asymptomatic hepatic steatosis, alcoholic hepatitis, hepatic fibrosis, and cirrhosis, which leads to morbidity and mortality and is responsible for 0.9% of global deaths. Alcohol consumption induces bacterial translocation and alteration of the gut microbiota composition. These changes in gut microbiota aggravate hepatic inflammation and fibrosis. Alteration of the gut microbiota leads to a weakened gut barrier and changes host immunity and metabolic function, especially related to bile acid metabolism. Modulation and treatment for the gut microbiota in ALD has been studied using probiotics, prebiotics, synbiotics, and fecal microbial transplantation with meaningful results. In this review, we focused on the interaction between alcohol and gut dysbiosis in ALD. Additionally, treatment approaches for gut dysbiosis, such as abstinence, diet, pro-, pre-, and synbiotics, antibiotics, and fecal microbial transplantation, are covered here under ALD. However, further research through human clinical trials is warranted to evaluate the appropriate gut microbiota-modulating agents for each condition related to ALD. |
| first_indexed | 2024-04-14T03:51:07Z |
| format | Article |
| id | doaj.art-e75a78180b434318ad9efc59fdbd402e |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-14T03:51:07Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-e75a78180b434318ad9efc59fdbd402e2022-12-22T02:14:02ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-07-01910.3389/fmed.2022.913842913842Gut microbiota-modulating agents in alcoholic liver disease: Links between host metabolism and gut microbiotaJang Han Jung0Sung-Eun Kim1Sung-Eun Kim2Ki Tae Suk3Ki Tae Suk4Dong Joon Kim5Dong Joon Kim6Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South KoreaDepartment of Internal Medicine, Hallym University College of Medicine, Chuncheon, South KoreaInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon, South KoreaDepartment of Internal Medicine, Hallym University College of Medicine, Chuncheon, South KoreaInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon, South KoreaDepartment of Internal Medicine, Hallym University College of Medicine, Chuncheon, South KoreaInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon, South KoreaAlcoholic liver disease (ALD) involves a wide spectrum of diseases, including asymptomatic hepatic steatosis, alcoholic hepatitis, hepatic fibrosis, and cirrhosis, which leads to morbidity and mortality and is responsible for 0.9% of global deaths. Alcohol consumption induces bacterial translocation and alteration of the gut microbiota composition. These changes in gut microbiota aggravate hepatic inflammation and fibrosis. Alteration of the gut microbiota leads to a weakened gut barrier and changes host immunity and metabolic function, especially related to bile acid metabolism. Modulation and treatment for the gut microbiota in ALD has been studied using probiotics, prebiotics, synbiotics, and fecal microbial transplantation with meaningful results. In this review, we focused on the interaction between alcohol and gut dysbiosis in ALD. Additionally, treatment approaches for gut dysbiosis, such as abstinence, diet, pro-, pre-, and synbiotics, antibiotics, and fecal microbial transplantation, are covered here under ALD. However, further research through human clinical trials is warranted to evaluate the appropriate gut microbiota-modulating agents for each condition related to ALD.https://www.frontiersin.org/articles/10.3389/fmed.2022.913842/fullalcoholic liver diseasemicrobiotadysbiosisgut-liver axishost metabolismfecal microbial transplant (FMT) |
| spellingShingle | Jang Han Jung Sung-Eun Kim Sung-Eun Kim Ki Tae Suk Ki Tae Suk Dong Joon Kim Dong Joon Kim Gut microbiota-modulating agents in alcoholic liver disease: Links between host metabolism and gut microbiota Frontiers in Medicine alcoholic liver disease microbiota dysbiosis gut-liver axis host metabolism fecal microbial transplant (FMT) |
| title | Gut microbiota-modulating agents in alcoholic liver disease: Links between host metabolism and gut microbiota |
| title_full | Gut microbiota-modulating agents in alcoholic liver disease: Links between host metabolism and gut microbiota |
| title_fullStr | Gut microbiota-modulating agents in alcoholic liver disease: Links between host metabolism and gut microbiota |
| title_full_unstemmed | Gut microbiota-modulating agents in alcoholic liver disease: Links between host metabolism and gut microbiota |
| title_short | Gut microbiota-modulating agents in alcoholic liver disease: Links between host metabolism and gut microbiota |
| title_sort | gut microbiota modulating agents in alcoholic liver disease links between host metabolism and gut microbiota |
| topic | alcoholic liver disease microbiota dysbiosis gut-liver axis host metabolism fecal microbial transplant (FMT) |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.913842/full |
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