Quorum Sensing-Mediated Lipid Oxidation Further Regulating the Environmental Adaptability of <i>Aspergillus ochraceus</i>
Quorum sensing (QS) is a cellular strategy of communication between intra- and inter-specific microorganisms, characterized by the release of quorum sensing molecules (QSMs) that achieve coordination to adaptation to the environment. In <i>Aspergillus</i>, lipids carry population density...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/4/491 |
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| author | Jing Gao Huiqing Liu Zhenzhen Zhang Zhihong Liang |
| author_facet | Jing Gao Huiqing Liu Zhenzhen Zhang Zhihong Liang |
| author_sort | Jing Gao |
| collection | DOAJ |
| description | Quorum sensing (QS) is a cellular strategy of communication between intra- and inter-specific microorganisms, characterized by the release of quorum sensing molecules (QSMs) that achieve coordination to adaptation to the environment. In <i>Aspergillus</i>, lipids carry population density-mediated stresses, and their oxidative metabolite oxylipins act as signaling to transmit information inside cells to regulate fungal development in a synchronized way. In this study, we investigated the regulation of density-dependent lipid metabolism in the toxigenic fungi <i>Aspergillus ochraceus</i> by the oxidative lipid metabolomics in conjunction with transcriptomics. In addition to proven hydroxyoctadecadienoic acids (HODEs), prostaglandins (PGs) also appear to have the properties of QSM. As a class of signaling molecule, oxylipins regulate the fungal morphology, secondary metabolism, and host infection through the G protein signaling pathway. The results of combined omics lay a foundation for further verification of oxylipin function, which is expected to elucidate the complex adaptability mechanism in <i>Aspergillus</i> and realize fungal utilization and damage control. |
| first_indexed | 2024-03-11T04:46:08Z |
| format | Article |
| id | doaj.art-e75ea2f418274c57a79946777893ff48 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T04:46:08Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-e75ea2f418274c57a79946777893ff482023-11-17T20:24:13ZengMDPI AGMetabolites2218-19892023-03-0113449110.3390/metabo13040491Quorum Sensing-Mediated Lipid Oxidation Further Regulating the Environmental Adaptability of <i>Aspergillus ochraceus</i>Jing Gao0Huiqing Liu1Zhenzhen Zhang2Zhihong Liang3College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaQuorum sensing (QS) is a cellular strategy of communication between intra- and inter-specific microorganisms, characterized by the release of quorum sensing molecules (QSMs) that achieve coordination to adaptation to the environment. In <i>Aspergillus</i>, lipids carry population density-mediated stresses, and their oxidative metabolite oxylipins act as signaling to transmit information inside cells to regulate fungal development in a synchronized way. In this study, we investigated the regulation of density-dependent lipid metabolism in the toxigenic fungi <i>Aspergillus ochraceus</i> by the oxidative lipid metabolomics in conjunction with transcriptomics. In addition to proven hydroxyoctadecadienoic acids (HODEs), prostaglandins (PGs) also appear to have the properties of QSM. As a class of signaling molecule, oxylipins regulate the fungal morphology, secondary metabolism, and host infection through the G protein signaling pathway. The results of combined omics lay a foundation for further verification of oxylipin function, which is expected to elucidate the complex adaptability mechanism in <i>Aspergillus</i> and realize fungal utilization and damage control.https://www.mdpi.com/2218-1989/13/4/491quorum sensingcell communicationoxylipinG-proteinlipid metabolismmultiomics |
| spellingShingle | Jing Gao Huiqing Liu Zhenzhen Zhang Zhihong Liang Quorum Sensing-Mediated Lipid Oxidation Further Regulating the Environmental Adaptability of <i>Aspergillus ochraceus</i> Metabolites quorum sensing cell communication oxylipin G-protein lipid metabolism multiomics |
| title | Quorum Sensing-Mediated Lipid Oxidation Further Regulating the Environmental Adaptability of <i>Aspergillus ochraceus</i> |
| title_full | Quorum Sensing-Mediated Lipid Oxidation Further Regulating the Environmental Adaptability of <i>Aspergillus ochraceus</i> |
| title_fullStr | Quorum Sensing-Mediated Lipid Oxidation Further Regulating the Environmental Adaptability of <i>Aspergillus ochraceus</i> |
| title_full_unstemmed | Quorum Sensing-Mediated Lipid Oxidation Further Regulating the Environmental Adaptability of <i>Aspergillus ochraceus</i> |
| title_short | Quorum Sensing-Mediated Lipid Oxidation Further Regulating the Environmental Adaptability of <i>Aspergillus ochraceus</i> |
| title_sort | quorum sensing mediated lipid oxidation further regulating the environmental adaptability of i aspergillus ochraceus i |
| topic | quorum sensing cell communication oxylipin G-protein lipid metabolism multiomics |
| url | https://www.mdpi.com/2218-1989/13/4/491 |
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