Computer‐Assisted Image Analysis in Assessment of Peripheral Joint MRI in Inflammatory Arthritis: A Systematic Review and Meta‐analysis
Objective To summarize the feasibility of computer‐assisted quantification of joint pathologies on magnetic resonance imaging (MRI) in patients with inflammatory arthritis by evaluating the published data on reliability, validity, and feasibility. Methods A systematic literature search was performed...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-08-01
|
| Series: | ACR Open Rheumatology |
| Online Access: | https://doi.org/10.1002/acr2.11450 |
| _version_ | 1828438837287714816 |
|---|---|
| author | Arya Haj‐Mirzaian Olga Kubassova Mikael Boesen John Carrino Paul Bird |
| author_facet | Arya Haj‐Mirzaian Olga Kubassova Mikael Boesen John Carrino Paul Bird |
| author_sort | Arya Haj‐Mirzaian |
| collection | DOAJ |
| description | Objective To summarize the feasibility of computer‐assisted quantification of joint pathologies on magnetic resonance imaging (MRI) in patients with inflammatory arthritis by evaluating the published data on reliability, validity, and feasibility. Methods A systematic literature search was performed for original articles published from January 1, 1985, to January 1, 2021. We selected studies in which patients with inflammatory arthritis were enrolled, and arthritis‐related structural damage/synovitis in peripheral joints was assessed on non‐contrast‐enhanced, contrast‐enhanced (CE), or dynamic CE (DCE)‐MRI using (semi)automated methods. Data were pooled using random‐effects model. Results Twenty‐eight studies consisting of 1342 MRIs were included (mean age, 54.8 years; 66.7% female; duration of arthritis, 3.6 years). Among clinical/laboratory factors, synovial membrane volume (SV) was moderately correlated with erthrocyte sedimentation rate (ESR) level (P < 0.01). Pooled analysis showed an overall excellent intra‐ and inter‐reader reliability for computer‐aided quantification of bone erosion volume (BEV; r = 0.97 [95% CI: 0.92‐0.99], 0.93 [0.87‐0.97]), SV (r = 0.98 [95% CI: 0.90‐0.99], 0.86 [0.78‐0.91]), and DCE‐MRI perfusion parameters (r = 0.96‐0.99). Meta‐regression showed that computer‐aided and manual methods provide comparable reliability (P > 0.05). Computer‐aided measurement of BEV (r = 0.92), SV (r = 0.82), and DCE‐MRI biomarkers (r = 0.72 N‐total; r = 0.74 N‐plateau; r = 0.64 N‐washout) were significantly correlated with the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS; P < 0.01), allowing for earlier assessment of drug efficacy. On average, (semi)automated analysis of BEV/SV took 17 minutes (vs. 9 minutes for the RAMRIS) and DCE‐MRI took 4 minutes (vs. 33 minutes for manual assessment). Conclusion Computer‐aided image quantification technologies demonstrate excellent reliability and validity when used to quantify MRI pathologies of peripheral joints in patients with inflammatory arthritis. Computer‐aided evaluation of inflammatory arthritis is an emerging field and should be considered as a viable complement to conventional observer‐based scoring methods for clinical trials application. |
| first_indexed | 2024-12-10T20:13:04Z |
| format | Article |
| id | doaj.art-e7607a70f16247e78bd5e2e69c38921c |
| institution | Directory Open Access Journal |
| issn | 2578-5745 |
| language | English |
| last_indexed | 2024-12-10T20:13:04Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | ACR Open Rheumatology |
| spelling | doaj.art-e7607a70f16247e78bd5e2e69c38921c2022-12-22T01:35:15ZengWileyACR Open Rheumatology2578-57452022-08-014872173410.1002/acr2.11450Computer‐Assisted Image Analysis in Assessment of Peripheral Joint MRI in Inflammatory Arthritis: A Systematic Review and Meta‐analysisArya Haj‐Mirzaian0Olga Kubassova1Mikael Boesen2John Carrino3Paul Bird4Johns Hopkins Hospital Baltimore MarylandImage Analysis Group London United KingdomUniversity Hospital Bispebjerg and Frederiksberg; The Parker Institute Copenhagen DenmarkHospital for Special Surgery Hackensack New JerseyUniversity of New South Wales Sydney New South Wales AustraliaObjective To summarize the feasibility of computer‐assisted quantification of joint pathologies on magnetic resonance imaging (MRI) in patients with inflammatory arthritis by evaluating the published data on reliability, validity, and feasibility. Methods A systematic literature search was performed for original articles published from January 1, 1985, to January 1, 2021. We selected studies in which patients with inflammatory arthritis were enrolled, and arthritis‐related structural damage/synovitis in peripheral joints was assessed on non‐contrast‐enhanced, contrast‐enhanced (CE), or dynamic CE (DCE)‐MRI using (semi)automated methods. Data were pooled using random‐effects model. Results Twenty‐eight studies consisting of 1342 MRIs were included (mean age, 54.8 years; 66.7% female; duration of arthritis, 3.6 years). Among clinical/laboratory factors, synovial membrane volume (SV) was moderately correlated with erthrocyte sedimentation rate (ESR) level (P < 0.01). Pooled analysis showed an overall excellent intra‐ and inter‐reader reliability for computer‐aided quantification of bone erosion volume (BEV; r = 0.97 [95% CI: 0.92‐0.99], 0.93 [0.87‐0.97]), SV (r = 0.98 [95% CI: 0.90‐0.99], 0.86 [0.78‐0.91]), and DCE‐MRI perfusion parameters (r = 0.96‐0.99). Meta‐regression showed that computer‐aided and manual methods provide comparable reliability (P > 0.05). Computer‐aided measurement of BEV (r = 0.92), SV (r = 0.82), and DCE‐MRI biomarkers (r = 0.72 N‐total; r = 0.74 N‐plateau; r = 0.64 N‐washout) were significantly correlated with the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS; P < 0.01), allowing for earlier assessment of drug efficacy. On average, (semi)automated analysis of BEV/SV took 17 minutes (vs. 9 minutes for the RAMRIS) and DCE‐MRI took 4 minutes (vs. 33 minutes for manual assessment). Conclusion Computer‐aided image quantification technologies demonstrate excellent reliability and validity when used to quantify MRI pathologies of peripheral joints in patients with inflammatory arthritis. Computer‐aided evaluation of inflammatory arthritis is an emerging field and should be considered as a viable complement to conventional observer‐based scoring methods for clinical trials application.https://doi.org/10.1002/acr2.11450 |
| spellingShingle | Arya Haj‐Mirzaian Olga Kubassova Mikael Boesen John Carrino Paul Bird Computer‐Assisted Image Analysis in Assessment of Peripheral Joint MRI in Inflammatory Arthritis: A Systematic Review and Meta‐analysis ACR Open Rheumatology |
| title | Computer‐Assisted Image Analysis in Assessment of Peripheral Joint MRI in Inflammatory Arthritis: A Systematic Review and Meta‐analysis |
| title_full | Computer‐Assisted Image Analysis in Assessment of Peripheral Joint MRI in Inflammatory Arthritis: A Systematic Review and Meta‐analysis |
| title_fullStr | Computer‐Assisted Image Analysis in Assessment of Peripheral Joint MRI in Inflammatory Arthritis: A Systematic Review and Meta‐analysis |
| title_full_unstemmed | Computer‐Assisted Image Analysis in Assessment of Peripheral Joint MRI in Inflammatory Arthritis: A Systematic Review and Meta‐analysis |
| title_short | Computer‐Assisted Image Analysis in Assessment of Peripheral Joint MRI in Inflammatory Arthritis: A Systematic Review and Meta‐analysis |
| title_sort | computer assisted image analysis in assessment of peripheral joint mri in inflammatory arthritis a systematic review and meta analysis |
| url | https://doi.org/10.1002/acr2.11450 |
| work_keys_str_mv | AT aryahajmirzaian computerassistedimageanalysisinassessmentofperipheraljointmriininflammatoryarthritisasystematicreviewandmetaanalysis AT olgakubassova computerassistedimageanalysisinassessmentofperipheraljointmriininflammatoryarthritisasystematicreviewandmetaanalysis AT mikaelboesen computerassistedimageanalysisinassessmentofperipheraljointmriininflammatoryarthritisasystematicreviewandmetaanalysis AT johncarrino computerassistedimageanalysisinassessmentofperipheraljointmriininflammatoryarthritisasystematicreviewandmetaanalysis AT paulbird computerassistedimageanalysisinassessmentofperipheraljointmriininflammatoryarthritisasystematicreviewandmetaanalysis |