Optimal strategies of oncolytic virus-bortezomib therapy via the apoptotic, necroptotic, and oncolysis signaling network

Optimal strategies of oncolytic virus-bortezomib therapy via the apoptotic, necroptotic, and oncolysis signaling network

Bortezomib and oncolytic virotherapy are two emerging targeted cancer therapies. Bortezomib, a proteasome inhibitor, disrupts protein degradation in cells, leading to the accumulation of unfolded proteins that induce apoptosis. On the other hand, virotherapy uses genetically modified oncolytic virus...

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Bibliographic Details
Main Authors: Donggu Lee, Aurelio A. de los Reyes V, Yangjin Kim
Format: Article
Language:English
Published: AIMS Press 2024-02-01
Series:Mathematical Biosciences and Engineering
Subjects:
oncolytic virus
bortezomib
mathematical model
optimal control theory
Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2024173?viewType=HTML

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