Expression of p63, p53 and Ki-67 in Patients with Cervical Intraepithelial Neoplasia

Objective: Cervical intraepithelial neoplasia (CIN) is a dysplastic process in cervical squamous epithelium and carries a risk of progression to cervical cancer. The aim of this study was to compare expression of three biomarkers named p53, p63 and Ki-67 in patients with various grades of cervical i...

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Main Authors: Androniks MITILDZANS, Anastasija ARECHVO, Dace REZEBERGA, Sergejs ISAJEVS
Format: Article
Language:English
Published: Federation of Turkish Pathology Societies 2017-01-01
Series:Türk Patoloji Dergisi
Subjects:
Online Access:http://www.turkjpath.org/pdf.php3?id=1810
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author Androniks MITILDZANS
Anastasija ARECHVO
Dace REZEBERGA
Sergejs ISAJEVS
author_facet Androniks MITILDZANS
Anastasija ARECHVO
Dace REZEBERGA
Sergejs ISAJEVS
author_sort Androniks MITILDZANS
collection DOAJ
description Objective: Cervical intraepithelial neoplasia (CIN) is a dysplastic process in cervical squamous epithelium and carries a risk of progression to cervical cancer. The aim of this study was to compare expression of three biomarkers named p53, p63 and Ki-67 in patients with various grades of cervical intraepithelial neoplasia and in a control group. Material and Method: 58 patients were enrolled in the study. Each patient underwent a colposcopy-guided biopsy of the cervix. Immunostaining for markers (p53, p63 and Ki-67) was performed on tissue samples of normal cases (n=10), CIN I (n=20), CIN II (n=14), and CIN III (n=14). Results: Our study showed a significant increase of the expression of the analyzed biomarkers in most patients with CIN III compared to CIN II and CIN I. Furthermore, p53 and p63 were significantly increased in CIN I compared to the control group. Conclusion: The expression of Ki-67, p63 and p53 differed between CIN I, CIN II and CIN III. p63 and p53 were reliable biomarkers to distinguish reactive changes from CIN I, while all three biomarkers (Ki-67, p53 and p63) had a high degree of sensitivity and specificity to distinguish between CIN III, CIN II and CIN I.
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spelling doaj.art-e761372ac2c94336b68f9523d385da7b2023-02-15T16:14:12ZengFederation of Turkish Pathology SocietiesTürk Patoloji Dergisi1018-56151309-57302017-01-0133191610.5146/tjpath.2016.01373Expression of p63, p53 and Ki-67 in Patients with Cervical Intraepithelial NeoplasiaAndroniks MITILDZANSAnastasija ARECHVODace REZEBERGASergejs ISAJEVSObjective: Cervical intraepithelial neoplasia (CIN) is a dysplastic process in cervical squamous epithelium and carries a risk of progression to cervical cancer. The aim of this study was to compare expression of three biomarkers named p53, p63 and Ki-67 in patients with various grades of cervical intraepithelial neoplasia and in a control group. Material and Method: 58 patients were enrolled in the study. Each patient underwent a colposcopy-guided biopsy of the cervix. Immunostaining for markers (p53, p63 and Ki-67) was performed on tissue samples of normal cases (n=10), CIN I (n=20), CIN II (n=14), and CIN III (n=14). Results: Our study showed a significant increase of the expression of the analyzed biomarkers in most patients with CIN III compared to CIN II and CIN I. Furthermore, p53 and p63 were significantly increased in CIN I compared to the control group. Conclusion: The expression of Ki-67, p63 and p53 differed between CIN I, CIN II and CIN III. p63 and p53 were reliable biomarkers to distinguish reactive changes from CIN I, while all three biomarkers (Ki-67, p53 and p63) had a high degree of sensitivity and specificity to distinguish between CIN III, CIN II and CIN I.http://www.turkjpath.org/pdf.php3?id=1810Cervical intraepithelial neoplasiap63p53Ki-67
spellingShingle Androniks MITILDZANS
Anastasija ARECHVO
Dace REZEBERGA
Sergejs ISAJEVS
Expression of p63, p53 and Ki-67 in Patients with Cervical Intraepithelial Neoplasia
Türk Patoloji Dergisi
Cervical intraepithelial neoplasia
p63
p53
Ki-67
title Expression of p63, p53 and Ki-67 in Patients with Cervical Intraepithelial Neoplasia
title_full Expression of p63, p53 and Ki-67 in Patients with Cervical Intraepithelial Neoplasia
title_fullStr Expression of p63, p53 and Ki-67 in Patients with Cervical Intraepithelial Neoplasia
title_full_unstemmed Expression of p63, p53 and Ki-67 in Patients with Cervical Intraepithelial Neoplasia
title_short Expression of p63, p53 and Ki-67 in Patients with Cervical Intraepithelial Neoplasia
title_sort expression of p63 p53 and ki 67 in patients with cervical intraepithelial neoplasia
topic Cervical intraepithelial neoplasia
p63
p53
Ki-67
url http://www.turkjpath.org/pdf.php3?id=1810
work_keys_str_mv AT androniksmitildzans expressionofp63p53andki67inpatientswithcervicalintraepithelialneoplasia
AT anastasijaarechvo expressionofp63p53andki67inpatientswithcervicalintraepithelialneoplasia
AT dacerezeberga expressionofp63p53andki67inpatientswithcervicalintraepithelialneoplasia
AT sergejsisajevs expressionofp63p53andki67inpatientswithcervicalintraepithelialneoplasia