RRM Prediction of Erythrocyte Band3 Protein as Alternative Receptor for SARS-CoV-2 Virus
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new coronavirus causing a worldwide pandemic. It is infecting respiratory organs and, in more severe cases, the lungs, where it is infecting the human cells through the angiotensin-converting enzyme 2 (ACE2) receptor. In severe cases,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/10/11/4053 |
| _version_ | 1827715235033645056 |
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| author | Irena Cosic Drasko Cosic Ivan Loncarevic |
| author_facet | Irena Cosic Drasko Cosic Ivan Loncarevic |
| author_sort | Irena Cosic |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new coronavirus causing a worldwide pandemic. It is infecting respiratory organs and, in more severe cases, the lungs, where it is infecting the human cells through the angiotensin-converting enzyme 2 (ACE2) receptor. In severe cases, it is characterized not only by difficulties in breathing through infected lungs, but also with disproportionally and, thus far, unexplained low levels of oxygen in the blood. Here, we propose that, besides the infection of respiratory organs through ACE2 receptors, there is an additional infection in the red blood cells (erythrocytes). There could be a possible for SARS-CoV-2 to pass through the alveoli membrane in the lungs and infect the red blood cells through another receptor. Using our own biophysical model, the Resonant Recognition Model, we propose that the red blood cell (RBC) Band3 protein on the surface of red blood cells is a possible entry point for the SARS-CoV-2 virus into red blood cells. |
| first_indexed | 2024-03-10T19:14:32Z |
| format | Article |
| id | doaj.art-e764992976004cf98cf85f223fdad8d2 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T19:14:32Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-e764992976004cf98cf85f223fdad8d22023-11-20T03:34:12ZengMDPI AGApplied Sciences2076-34172020-06-011011405310.3390/app10114053RRM Prediction of Erythrocyte Band3 Protein as Alternative Receptor for SARS-CoV-2 VirusIrena Cosic0Drasko Cosic1Ivan Loncarevic2AMALNA Consulting, Black Rock, Melbourne, VIC 3193, AustraliaAMALNA Consulting, Black Rock, Melbourne, VIC 3193, AustraliaQuantBioRes A/S - QBR A/S, 2860 Copenhagen, DenmarkSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new coronavirus causing a worldwide pandemic. It is infecting respiratory organs and, in more severe cases, the lungs, where it is infecting the human cells through the angiotensin-converting enzyme 2 (ACE2) receptor. In severe cases, it is characterized not only by difficulties in breathing through infected lungs, but also with disproportionally and, thus far, unexplained low levels of oxygen in the blood. Here, we propose that, besides the infection of respiratory organs through ACE2 receptors, there is an additional infection in the red blood cells (erythrocytes). There could be a possible for SARS-CoV-2 to pass through the alveoli membrane in the lungs and infect the red blood cells through another receptor. Using our own biophysical model, the Resonant Recognition Model, we propose that the red blood cell (RBC) Band3 protein on the surface of red blood cells is a possible entry point for the SARS-CoV-2 virus into red blood cells.https://www.mdpi.com/2076-3417/10/11/4053COVID-19SARS-CoV-2coronavirusACE2blood cellsprotein–receptor interaction |
| spellingShingle | Irena Cosic Drasko Cosic Ivan Loncarevic RRM Prediction of Erythrocyte Band3 Protein as Alternative Receptor for SARS-CoV-2 Virus Applied Sciences COVID-19 SARS-CoV-2 coronavirus ACE2 blood cells protein–receptor interaction |
| title | RRM Prediction of Erythrocyte Band3 Protein as Alternative Receptor for SARS-CoV-2 Virus |
| title_full | RRM Prediction of Erythrocyte Band3 Protein as Alternative Receptor for SARS-CoV-2 Virus |
| title_fullStr | RRM Prediction of Erythrocyte Band3 Protein as Alternative Receptor for SARS-CoV-2 Virus |
| title_full_unstemmed | RRM Prediction of Erythrocyte Band3 Protein as Alternative Receptor for SARS-CoV-2 Virus |
| title_short | RRM Prediction of Erythrocyte Band3 Protein as Alternative Receptor for SARS-CoV-2 Virus |
| title_sort | rrm prediction of erythrocyte band3 protein as alternative receptor for sars cov 2 virus |
| topic | COVID-19 SARS-CoV-2 coronavirus ACE2 blood cells protein–receptor interaction |
| url | https://www.mdpi.com/2076-3417/10/11/4053 |
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