Validation of the CALL score as a mortality prediction tool in a cohort of hospitalized COVID-19 patients in Chile
IntroductionThe CALL score is a predictive tool for respiratory failure progression in COVID-19. Whether the CALL score is useful to predict short- and medium-term mortality in an unvaccinated population is unknown.Materials and methodsThis is a prospective cohort study in unvaccinated inpatients wi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1164615/full |
| _version_ | 1797736108608454656 |
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| author | Matías Sanhueza Manuel Barrera Juan C. Pedemonte Juan C. Pedemonte Luis Rojas Luis Rojas |
| author_facet | Matías Sanhueza Manuel Barrera Juan C. Pedemonte Juan C. Pedemonte Luis Rojas Luis Rojas |
| author_sort | Matías Sanhueza |
| collection | DOAJ |
| description | IntroductionThe CALL score is a predictive tool for respiratory failure progression in COVID-19. Whether the CALL score is useful to predict short- and medium-term mortality in an unvaccinated population is unknown.Materials and methodsThis is a prospective cohort study in unvaccinated inpatients with a COVID-19 pneumonia diagnosis upon hospital admission. Patients were followed up for mortality at 28 days, 3, 6, and 12 months. Associations between CALL score and mortality were analyzed using logistic regression. The prediction performance was evaluated using the area under a receiver operating characteristic curve (AUROC).ResultsA total of 592 patients were included. On average, the CALL score was 9.25 (±2). Higher CALL scores were associated with increased mortality at 28 days [univariate: odds ratio (OR) 1.58 (95% CI, 1.34–1.88), p < 0.001; multivariate: OR 1.54 (95% CI, 1.26–1.87), p < 0.001] and 12 months [univariate OR 1.63 (95% CI, 1.38–1.93), p < 0.001; multivariate OR 1.63 (95% CI, 1.35–1.97), p < 0.001]. The prediction performance was good for both univariate [AUROC 0.739 (0.687–0.791) at 28 days and 0.869 (0.828–0.91) at 12 months] and multivariate models [AUROC 0.752 (0.704–0.8) at 28 days and 0.862 (0.82–0.905) at 12 months].ConclusionThe CALL score exhibits a good predictive capacity for short- and medium-term mortality in an unvaccinated population. |
| first_indexed | 2024-03-12T13:08:51Z |
| format | Article |
| id | doaj.art-e76512cff64942d7ac03847f14d4effd |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-12T13:08:51Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-e76512cff64942d7ac03847f14d4effd2023-08-28T11:14:52ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-08-011010.3389/fmed.2023.11646151164615Validation of the CALL score as a mortality prediction tool in a cohort of hospitalized COVID-19 patients in ChileMatías Sanhueza0Manuel Barrera1Juan C. Pedemonte2Juan C. Pedemonte3Luis Rojas4Luis Rojas5School of Medicine, Department of Internal Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileSchool of Medicine, Department of Internal Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileSchool of Medicine, Division of Anesthesiology, Pontificia Universidad Católica de Chile, Santiago, ChileSchool of Medicine, Program of Pharmacology and Toxicology, Pontificia Universidad Católica de Chile, Santiago, ChileSchool of Medicine, Department of Internal Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileSchool of Medicine, Program of Pharmacology and Toxicology, Pontificia Universidad Católica de Chile, Santiago, ChileIntroductionThe CALL score is a predictive tool for respiratory failure progression in COVID-19. Whether the CALL score is useful to predict short- and medium-term mortality in an unvaccinated population is unknown.Materials and methodsThis is a prospective cohort study in unvaccinated inpatients with a COVID-19 pneumonia diagnosis upon hospital admission. Patients were followed up for mortality at 28 days, 3, 6, and 12 months. Associations between CALL score and mortality were analyzed using logistic regression. The prediction performance was evaluated using the area under a receiver operating characteristic curve (AUROC).ResultsA total of 592 patients were included. On average, the CALL score was 9.25 (±2). Higher CALL scores were associated with increased mortality at 28 days [univariate: odds ratio (OR) 1.58 (95% CI, 1.34–1.88), p < 0.001; multivariate: OR 1.54 (95% CI, 1.26–1.87), p < 0.001] and 12 months [univariate OR 1.63 (95% CI, 1.38–1.93), p < 0.001; multivariate OR 1.63 (95% CI, 1.35–1.97), p < 0.001]. The prediction performance was good for both univariate [AUROC 0.739 (0.687–0.791) at 28 days and 0.869 (0.828–0.91) at 12 months] and multivariate models [AUROC 0.752 (0.704–0.8) at 28 days and 0.862 (0.82–0.905) at 12 months].ConclusionThe CALL score exhibits a good predictive capacity for short- and medium-term mortality in an unvaccinated population.https://www.frontiersin.org/articles/10.3389/fmed.2023.1164615/fullCALL scoreCOVID-19mortalitypredictioninpatients |
| spellingShingle | Matías Sanhueza Manuel Barrera Juan C. Pedemonte Juan C. Pedemonte Luis Rojas Luis Rojas Validation of the CALL score as a mortality prediction tool in a cohort of hospitalized COVID-19 patients in Chile Frontiers in Medicine CALL score COVID-19 mortality prediction inpatients |
| title | Validation of the CALL score as a mortality prediction tool in a cohort of hospitalized COVID-19 patients in Chile |
| title_full | Validation of the CALL score as a mortality prediction tool in a cohort of hospitalized COVID-19 patients in Chile |
| title_fullStr | Validation of the CALL score as a mortality prediction tool in a cohort of hospitalized COVID-19 patients in Chile |
| title_full_unstemmed | Validation of the CALL score as a mortality prediction tool in a cohort of hospitalized COVID-19 patients in Chile |
| title_short | Validation of the CALL score as a mortality prediction tool in a cohort of hospitalized COVID-19 patients in Chile |
| title_sort | validation of the call score as a mortality prediction tool in a cohort of hospitalized covid 19 patients in chile |
| topic | CALL score COVID-19 mortality prediction inpatients |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1164615/full |
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