Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder: A retrospective inpatient analysis
A retrospective study was conducted to analyze prescription pattern of clozapine in dual diagnosis inpatients' and to find out if there was any association between clozapine prescription and acute relapses either from psychiatric symptoms or from substance use disorder. All patients admitted at...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Psychiatry Research Communications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S277259872200037X |
| _version_ | 1811268088361910272 |
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| author | Joana Teixeira Sara Alexandre Carolina Cunha Filipe Raposo José Pedro Costa |
| author_facet | Joana Teixeira Sara Alexandre Carolina Cunha Filipe Raposo José Pedro Costa |
| author_sort | Joana Teixeira |
| collection | DOAJ |
| description | A retrospective study was conducted to analyze prescription pattern of clozapine in dual diagnosis inpatients' and to find out if there was any association between clozapine prescription and acute relapses either from psychiatric symptoms or from substance use disorder. All patients admitted at Lisbon's Psychiatric Hospital Center during a 4 months' period for psychiatric inpatient treatment with a dual diagnosis at discharge were selected and their clinical files were screened. From 536 patients, 17,5% had a dual diagnosis at discharge. Most frequent psychiatric diagnosis associated with substance use disorder was schizophrenia (50%), followed by major depression disorder (17%) and bipolar disorder (10,6%). Most frequent substance of abuse was alcohol, followed by cannabinoids, nicotine, cocaine, and opiates. At least one antipsychotic drug was prescribed to 85,1% patients, and clozapine was prescribed to 22,3%. There was a statistically significant association between clozapine prescription and prevention of acute relapses of psychiatric symptoms in dual diagnosis patients. Although there was no significant association between prescription of clozapine versus other antipsychotic drugs in the prevention of relapses of substance use, there was a larger than expected number of patients in clozapine that didn't have a relapse of substance use. |
| first_indexed | 2024-04-12T21:15:30Z |
| format | Article |
| id | doaj.art-e76633e613b2465185d87b705f057ec7 |
| institution | Directory Open Access Journal |
| issn | 2772-5987 |
| language | English |
| last_indexed | 2024-04-12T21:15:30Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Psychiatry Research Communications |
| spelling | doaj.art-e76633e613b2465185d87b705f057ec72022-12-22T03:16:29ZengElsevierPsychiatry Research Communications2772-59872022-09-0123100056Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder: A retrospective inpatient analysisJoana Teixeira0Sara Alexandre1Carolina Cunha2Filipe Raposo3José Pedro Costa4Alcohol and New Dependences' Treatment Unit, Lisbon's Psychiatric Hospital Center, Lisbon, Portugal; Faculty of Medicine, University of Lisbon, Lisbon, Portugal; Corresponding author.Alcohol and New Dependences' Treatment Unit, Lisbon's Psychiatric Hospital Center, Avenida do Brasil 53, 1749-002, Lisbon, Portugal.Pharmacy Department, Lisbon's Psychiatric Hospital Center, Lisbon, PortugalNova Medical School, Faculdade de Ciências Médicas, Lisbon, PortugalNova Medical School, Faculdade de Ciências Médicas, Lisbon, PortugalNova Medical School, Faculdade de Ciências Médicas, Lisbon, PortugalA retrospective study was conducted to analyze prescription pattern of clozapine in dual diagnosis inpatients' and to find out if there was any association between clozapine prescription and acute relapses either from psychiatric symptoms or from substance use disorder. All patients admitted at Lisbon's Psychiatric Hospital Center during a 4 months' period for psychiatric inpatient treatment with a dual diagnosis at discharge were selected and their clinical files were screened. From 536 patients, 17,5% had a dual diagnosis at discharge. Most frequent psychiatric diagnosis associated with substance use disorder was schizophrenia (50%), followed by major depression disorder (17%) and bipolar disorder (10,6%). Most frequent substance of abuse was alcohol, followed by cannabinoids, nicotine, cocaine, and opiates. At least one antipsychotic drug was prescribed to 85,1% patients, and clozapine was prescribed to 22,3%. There was a statistically significant association between clozapine prescription and prevention of acute relapses of psychiatric symptoms in dual diagnosis patients. Although there was no significant association between prescription of clozapine versus other antipsychotic drugs in the prevention of relapses of substance use, there was a larger than expected number of patients in clozapine that didn't have a relapse of substance use.http://www.sciencedirect.com/science/article/pii/S277259872200037XClozapineTreatmentRelapsesSchizophreniaDual diagnosisSubstance use disorder |
| spellingShingle | Joana Teixeira Sara Alexandre Carolina Cunha Filipe Raposo José Pedro Costa Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder: A retrospective inpatient analysis Psychiatry Research Communications Clozapine Treatment Relapses Schizophrenia Dual diagnosis Substance use disorder |
| title | Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder: A retrospective inpatient analysis |
| title_full | Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder: A retrospective inpatient analysis |
| title_fullStr | Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder: A retrospective inpatient analysis |
| title_full_unstemmed | Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder: A retrospective inpatient analysis |
| title_short | Impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder: A retrospective inpatient analysis |
| title_sort | impact of clozapine as the mainstay therapeutical approach to schizophrenia and substance use disorder a retrospective inpatient analysis |
| topic | Clozapine Treatment Relapses Schizophrenia Dual diagnosis Substance use disorder |
| url | http://www.sciencedirect.com/science/article/pii/S277259872200037X |
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