Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2
Since immune system and internal environment in vivo are large and complex, the interpretation of the observed immune effect from the perspective of a single immune cell or antibody seems a little feeble. Many studies have shown that specific antibodies against “ former” viruses have a reduced abili...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1008285/full |
| _version_ | 1811251568095264768 |
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| author | Yalong Yang Yalong Yang Fenghua Xu |
| author_facet | Yalong Yang Yalong Yang Fenghua Xu |
| author_sort | Yalong Yang |
| collection | DOAJ |
| description | Since immune system and internal environment in vivo are large and complex, the interpretation of the observed immune effect from the perspective of a single immune cell or antibody seems a little feeble. Many studies have shown that specific antibodies against “ former” viruses have a reduced ability to neutralize “new” mutant strains. However, there is no comprehensive and clear view of whether there will be Antibody-dependent enhancement (ADE). We review the latest relevant studies, hoping to explain the ADE of SARS-CoV-2 infection sometimes observed in some patients. |
| first_indexed | 2024-04-12T16:22:24Z |
| format | Article |
| id | doaj.art-e768c20eca2b4d0fa8c14d43cdbdc4ed |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T16:22:24Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e768c20eca2b4d0fa8c14d43cdbdc4ed2022-12-22T03:25:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-10-011310.3389/fimmu.2022.10082851008285Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2Yalong Yang0Yalong Yang1Fenghua Xu2Pharmaceutical Sciences Research Division, Department of Pharmacy, Medical Supplies Center, People’s Liberation Army (PLA) General Hospital, Beijing, ChinaMedical School of Chinese People’s Liberation Army (PLA), Beijing, ChinaPharmaceutical Sciences Research Division, Department of Pharmacy, Medical Supplies Center, People’s Liberation Army (PLA) General Hospital, Beijing, ChinaSince immune system and internal environment in vivo are large and complex, the interpretation of the observed immune effect from the perspective of a single immune cell or antibody seems a little feeble. Many studies have shown that specific antibodies against “ former” viruses have a reduced ability to neutralize “new” mutant strains. However, there is no comprehensive and clear view of whether there will be Antibody-dependent enhancement (ADE). We review the latest relevant studies, hoping to explain the ADE of SARS-CoV-2 infection sometimes observed in some patients.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1008285/fullSARS-CoV-2antibody-dependent enhancement (ADE)mechanismreceptor-mediatedmultiple roles of macrophagescountermeasures |
| spellingShingle | Yalong Yang Yalong Yang Fenghua Xu Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2 Frontiers in Immunology SARS-CoV-2 antibody-dependent enhancement (ADE) mechanism receptor-mediated multiple roles of macrophages countermeasures |
| title | Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2 |
| title_full | Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2 |
| title_fullStr | Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2 |
| title_full_unstemmed | Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2 |
| title_short | Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2 |
| title_sort | evolving understanding of antibody dependent enhancement ade of sars cov 2 |
| topic | SARS-CoV-2 antibody-dependent enhancement (ADE) mechanism receptor-mediated multiple roles of macrophages countermeasures |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1008285/full |
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