Comparison of Treatment Patterns and Clinical Outcomes by Gender in Locally Advanced Head and Neck Squamous Cell Carcinoma (KCSG HN13-01)
We aimed to compare treatment modalities and outcomes by gender in patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC). We characterized the sex-specific differences and compared the overall survival (OS) between male and female patients in a multicenter cohort of LA-HNSC...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/2/471 |
| _version_ | 1797444811367645184 |
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| author | Yun-Gyoo Lee Eun Joo Kang Bhumsuk Keam Jin-Hyuk Choi Jin-Soo Kim Keon Uk Park Kyoung Eun Lee Keun-Wook Lee Min Kyoung Kim Hee Kyung Ahn Seong Hoon Shin Hye Ryun Kim Sung-Bae Kim Hyo Jung Kim Hwan Jung Yun |
| author_facet | Yun-Gyoo Lee Eun Joo Kang Bhumsuk Keam Jin-Hyuk Choi Jin-Soo Kim Keon Uk Park Kyoung Eun Lee Keun-Wook Lee Min Kyoung Kim Hee Kyung Ahn Seong Hoon Shin Hye Ryun Kim Sung-Bae Kim Hyo Jung Kim Hwan Jung Yun |
| author_sort | Yun-Gyoo Lee |
| collection | DOAJ |
| description | We aimed to compare treatment modalities and outcomes by gender in patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC). We characterized the sex-specific differences and compared the overall survival (OS) between male and female patients in a multicenter cohort of LA-HNSCC. To minimize the observed confounding, propensity score matching was utilized. The study included 445 patients; 385 (86.5%) were men and 60 (13.5%) were women. In terms of age, smoking habits, drinking habits, and primary tumor locations, there was a significant imbalance in sex before the matching. Propensity score matching yielded 60 patient pairs, with no statistical difference between the sexes in terms of their characteristics. As for the treatment strategies, there were no significant differences between the sexes before (<i>p</i> = 0.260) and after (<i>p</i> = 0.585) the propensity score matching. When comparing the survival probabilities between the sexes, OS was not significantly different in the overall (HR 1.02; 95% CI 0.59–1.76; <i>p</i> = 0.938) and propensity-score-matched population (HR 1.46; 95% CI 0.68–3.17; <i>p</i> = 0.331). These results suggest that there was no difference in prognosis by gender in the treatment modalities and outcomes of LA-HNSCC in real-world practice. |
| first_indexed | 2024-03-09T13:17:57Z |
| format | Article |
| id | doaj.art-e769245ffe7340be8603e1795b8ec92c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T13:17:57Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e769245ffe7340be8603e1795b8ec92c2023-11-30T21:34:21ZengMDPI AGCancers2072-66942023-01-0115247110.3390/cancers15020471Comparison of Treatment Patterns and Clinical Outcomes by Gender in Locally Advanced Head and Neck Squamous Cell Carcinoma (KCSG HN13-01)Yun-Gyoo Lee0Eun Joo Kang1Bhumsuk Keam2Jin-Hyuk Choi3Jin-Soo Kim4Keon Uk Park5Kyoung Eun Lee6Keun-Wook Lee7Min Kyoung Kim8Hee Kyung Ahn9Seong Hoon Shin10Hye Ryun Kim11Sung-Bae Kim12Hyo Jung Kim13Hwan Jung Yun14Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of KoreaDepartment of Internal Medicine, Korea University Guro Hospital, Seoul 08308, Republic of KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of KoreaDepartment of Hematology-Oncology, Ajou University Hospital, Suwon 16499, Republic of KoreaDepartment of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul 07061, Republic of KoreaDepartment of Hemato-Oncology, Keimyung University Dongsan Medical Center, Daegu 42601, Republic of KoreaDepartment of Hematology and Oncology, Ewha Women’s University Hospital, Seoul 07985, Republic of KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of KoreaDepartment of Hematology-Oncology, Yeungnam University Medical Center, Daegu 42415, Republic of KoreaDepartment of Internal Medicine, Gachon University Gil Medical Center, Incheon 21565, Republic of KoreaDepartment of Internal Medicine, Kosin University Gospel Hospital, Busan 49267, Republic of KoreaDepartment of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaDepartment of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of KoreaDepartment of Internal Medicine, Chungnam National University Hospital, Daejeon 35015, Republic of KoreaWe aimed to compare treatment modalities and outcomes by gender in patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC). We characterized the sex-specific differences and compared the overall survival (OS) between male and female patients in a multicenter cohort of LA-HNSCC. To minimize the observed confounding, propensity score matching was utilized. The study included 445 patients; 385 (86.5%) were men and 60 (13.5%) were women. In terms of age, smoking habits, drinking habits, and primary tumor locations, there was a significant imbalance in sex before the matching. Propensity score matching yielded 60 patient pairs, with no statistical difference between the sexes in terms of their characteristics. As for the treatment strategies, there were no significant differences between the sexes before (<i>p</i> = 0.260) and after (<i>p</i> = 0.585) the propensity score matching. When comparing the survival probabilities between the sexes, OS was not significantly different in the overall (HR 1.02; 95% CI 0.59–1.76; <i>p</i> = 0.938) and propensity-score-matched population (HR 1.46; 95% CI 0.68–3.17; <i>p</i> = 0.331). These results suggest that there was no difference in prognosis by gender in the treatment modalities and outcomes of LA-HNSCC in real-world practice.https://www.mdpi.com/2072-6694/15/2/471locally advanced head and neck squamous cell carcinomagenderclinical outcome |
| spellingShingle | Yun-Gyoo Lee Eun Joo Kang Bhumsuk Keam Jin-Hyuk Choi Jin-Soo Kim Keon Uk Park Kyoung Eun Lee Keun-Wook Lee Min Kyoung Kim Hee Kyung Ahn Seong Hoon Shin Hye Ryun Kim Sung-Bae Kim Hyo Jung Kim Hwan Jung Yun Comparison of Treatment Patterns and Clinical Outcomes by Gender in Locally Advanced Head and Neck Squamous Cell Carcinoma (KCSG HN13-01) Cancers locally advanced head and neck squamous cell carcinoma gender clinical outcome |
| title | Comparison of Treatment Patterns and Clinical Outcomes by Gender in Locally Advanced Head and Neck Squamous Cell Carcinoma (KCSG HN13-01) |
| title_full | Comparison of Treatment Patterns and Clinical Outcomes by Gender in Locally Advanced Head and Neck Squamous Cell Carcinoma (KCSG HN13-01) |
| title_fullStr | Comparison of Treatment Patterns and Clinical Outcomes by Gender in Locally Advanced Head and Neck Squamous Cell Carcinoma (KCSG HN13-01) |
| title_full_unstemmed | Comparison of Treatment Patterns and Clinical Outcomes by Gender in Locally Advanced Head and Neck Squamous Cell Carcinoma (KCSG HN13-01) |
| title_short | Comparison of Treatment Patterns and Clinical Outcomes by Gender in Locally Advanced Head and Neck Squamous Cell Carcinoma (KCSG HN13-01) |
| title_sort | comparison of treatment patterns and clinical outcomes by gender in locally advanced head and neck squamous cell carcinoma kcsg hn13 01 |
| topic | locally advanced head and neck squamous cell carcinoma gender clinical outcome |
| url | https://www.mdpi.com/2072-6694/15/2/471 |
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