Safety and efficacy of l‐tryptophan produced by fermentation with Corynebacterium glutamicum KCCM 80176 for all animal species
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐tryptophan produced by fermentation with a genetically modified strain of Corynebacterium glutamicum (KCCM 80176) w...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-06-01
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| Series: | EFSA Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.2903/j.efsa.2019.5729 |
| _version_ | 1818722322170773504 |
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| author | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Birgit Dusemund Maryline Kouba Mojca Kos Durjava Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Lucio Costa Noël Dierick Gerhard Flachowsky Boet Glandorf Alberto Mantovani Robert John Wallace Montserrat Anguita Paola Manini Jordi Tarrés‐Call Fernando Ramos |
| author_facet | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Birgit Dusemund Maryline Kouba Mojca Kos Durjava Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Lucio Costa Noël Dierick Gerhard Flachowsky Boet Glandorf Alberto Mantovani Robert John Wallace Montserrat Anguita Paola Manini Jordi Tarrés‐Call Fernando Ramos |
| author_sort | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) |
| collection | DOAJ |
| description | Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐tryptophan produced by fermentation with a genetically modified strain of Corynebacterium glutamicum (KCCM 80176) when used as a nutritional additive in feed and water for drinking for all animal species. Viable cells of the production strain and its recombinant DNA were not detected in the additive. l‐Tryptophan manufactured by fermentation using C. glutamicum KCCM 80176 does not give rise to any safety concern with regard to the genetic modification of the production strain. The use of l‐tryptophan produced using C. glutamicum KCCM 80176 in supplementing feed to compensate for tryptophan deficiency in feedingstuffs is safe for non‐ruminant target species and in ruminants when a rumen‐protected form is used. The use of l‐tryptophan produced by C. glutamicum KCCM 80176 in animal nutrition presents no safety concerns to consumers of animal products. l‐Tryptophan produced by C. glutamicum KCCM 80176 is considered not toxic by inhalation, not irritant to skin or eyes and not a dermal sensitiser. l‐Tryptophan produced by C. glutamicum KCCM 80176 is safe for the environment. l‐Tryptophan produced by C. glutamicum KCCM 80176 is regarded as an effective source of the amino acid l‐tryptophan for all non‐ruminant species. If l‐tryptophan is intended for use in ruminants, it should be protected from ruminal degradation. |
| first_indexed | 2024-12-17T20:52:47Z |
| format | Article |
| id | doaj.art-e76b550c573640b5994dbd89c9aa8fe3 |
| institution | Directory Open Access Journal |
| issn | 1831-4732 |
| language | English |
| last_indexed | 2024-12-17T20:52:47Z |
| publishDate | 2019-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj.art-e76b550c573640b5994dbd89c9aa8fe32022-12-21T21:32:59ZengWileyEFSA Journal1831-47322019-06-01176n/an/a10.2903/j.efsa.2019.5729Safety and efficacy of l‐tryptophan produced by fermentation with Corynebacterium glutamicum KCCM 80176 for all animal speciesEFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Vasileios BampidisGiovanna AzimontiMaria de Lourdes BastosHenrik ChristensenBirgit DusemundMaryline KoubaMojca Kos DurjavaMarta López‐AlonsoSecundino López PuenteFrancesca MarconBaltasar MayoAlena PechováMariana PetkovaYolanda SanzRoberto Edoardo VillaRuud WoutersenLucio CostaNoël DierickGerhard FlachowskyBoet GlandorfAlberto MantovaniRobert John WallaceMontserrat AnguitaPaola ManiniJordi Tarrés‐CallFernando RamosAbstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐tryptophan produced by fermentation with a genetically modified strain of Corynebacterium glutamicum (KCCM 80176) when used as a nutritional additive in feed and water for drinking for all animal species. Viable cells of the production strain and its recombinant DNA were not detected in the additive. l‐Tryptophan manufactured by fermentation using C. glutamicum KCCM 80176 does not give rise to any safety concern with regard to the genetic modification of the production strain. The use of l‐tryptophan produced using C. glutamicum KCCM 80176 in supplementing feed to compensate for tryptophan deficiency in feedingstuffs is safe for non‐ruminant target species and in ruminants when a rumen‐protected form is used. The use of l‐tryptophan produced by C. glutamicum KCCM 80176 in animal nutrition presents no safety concerns to consumers of animal products. l‐Tryptophan produced by C. glutamicum KCCM 80176 is considered not toxic by inhalation, not irritant to skin or eyes and not a dermal sensitiser. l‐Tryptophan produced by C. glutamicum KCCM 80176 is safe for the environment. l‐Tryptophan produced by C. glutamicum KCCM 80176 is regarded as an effective source of the amino acid l‐tryptophan for all non‐ruminant species. If l‐tryptophan is intended for use in ruminants, it should be protected from ruminal degradation.https://doi.org/10.2903/j.efsa.2019.5729tryptophanCorynebacterium glutamicum KCCM 80176amino acidnutritional additivesafetyefficacy |
| spellingShingle | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Birgit Dusemund Maryline Kouba Mojca Kos Durjava Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Lucio Costa Noël Dierick Gerhard Flachowsky Boet Glandorf Alberto Mantovani Robert John Wallace Montserrat Anguita Paola Manini Jordi Tarrés‐Call Fernando Ramos Safety and efficacy of l‐tryptophan produced by fermentation with Corynebacterium glutamicum KCCM 80176 for all animal species EFSA Journal tryptophan Corynebacterium glutamicum KCCM 80176 amino acid nutritional additive safety efficacy |
| title | Safety and efficacy of l‐tryptophan produced by fermentation with Corynebacterium glutamicum KCCM 80176 for all animal species |
| title_full | Safety and efficacy of l‐tryptophan produced by fermentation with Corynebacterium glutamicum KCCM 80176 for all animal species |
| title_fullStr | Safety and efficacy of l‐tryptophan produced by fermentation with Corynebacterium glutamicum KCCM 80176 for all animal species |
| title_full_unstemmed | Safety and efficacy of l‐tryptophan produced by fermentation with Corynebacterium glutamicum KCCM 80176 for all animal species |
| title_short | Safety and efficacy of l‐tryptophan produced by fermentation with Corynebacterium glutamicum KCCM 80176 for all animal species |
| title_sort | safety and efficacy of l tryptophan produced by fermentation with corynebacterium glutamicum kccm 80176 for all animal species |
| topic | tryptophan Corynebacterium glutamicum KCCM 80176 amino acid nutritional additive safety efficacy |
| url | https://doi.org/10.2903/j.efsa.2019.5729 |
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