Balancing act: the complex role of NK cells in immune regulation
Natural killer (NK) cells, as fundamental components of innate immunity, can quickly react to abnormalities within the body. In-depth research has revealed that NK cells possess regulatory functions not only in innate immunity but also in adaptive immunity under various conditions. Multiple aspects...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1275028/full |
| _version_ | 1797640510830018560 |
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| author | Hongwei Jiang Hongwei Jiang Hongwei Jiang Jingting Jiang Jingting Jiang Jingting Jiang |
| author_facet | Hongwei Jiang Hongwei Jiang Hongwei Jiang Jingting Jiang Jingting Jiang Jingting Jiang |
| author_sort | Hongwei Jiang |
| collection | DOAJ |
| description | Natural killer (NK) cells, as fundamental components of innate immunity, can quickly react to abnormalities within the body. In-depth research has revealed that NK cells possess regulatory functions not only in innate immunity but also in adaptive immunity under various conditions. Multiple aspects of the adaptive immune process are regulated through NK cells. In our review, we have integrated multiple studies to illuminate the regulatory function of NK cells in regulating B cell and T cell responses during adaptive immune processes, focusing on aspects including viral infections and the tumor microenvironment (TME). These insights provide us with many new understandings on how NK cells regulate different phases of the adaptive immune response. |
| first_indexed | 2024-03-11T13:32:59Z |
| format | Article |
| id | doaj.art-e76b58125c084d8dad3b5f80e624ce2b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T13:32:59Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e76b58125c084d8dad3b5f80e624ce2b2023-11-02T16:58:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-11-011410.3389/fimmu.2023.12750281275028Balancing act: the complex role of NK cells in immune regulationHongwei Jiang0Hongwei Jiang1Hongwei Jiang2Jingting Jiang3Jingting Jiang4Jingting Jiang5Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaJiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaInstitute for Cell Therapy, Soochow University, Changzhou, Jiangsu, ChinaDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaJiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaInstitute for Cell Therapy, Soochow University, Changzhou, Jiangsu, ChinaNatural killer (NK) cells, as fundamental components of innate immunity, can quickly react to abnormalities within the body. In-depth research has revealed that NK cells possess regulatory functions not only in innate immunity but also in adaptive immunity under various conditions. Multiple aspects of the adaptive immune process are regulated through NK cells. In our review, we have integrated multiple studies to illuminate the regulatory function of NK cells in regulating B cell and T cell responses during adaptive immune processes, focusing on aspects including viral infections and the tumor microenvironment (TME). These insights provide us with many new understandings on how NK cells regulate different phases of the adaptive immune response.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1275028/fullNK celladaptive immunityregulationT cellB cellvirus infection |
| spellingShingle | Hongwei Jiang Hongwei Jiang Hongwei Jiang Jingting Jiang Jingting Jiang Jingting Jiang Balancing act: the complex role of NK cells in immune regulation Frontiers in Immunology NK cell adaptive immunity regulation T cell B cell virus infection |
| title | Balancing act: the complex role of NK cells in immune regulation |
| title_full | Balancing act: the complex role of NK cells in immune regulation |
| title_fullStr | Balancing act: the complex role of NK cells in immune regulation |
| title_full_unstemmed | Balancing act: the complex role of NK cells in immune regulation |
| title_short | Balancing act: the complex role of NK cells in immune regulation |
| title_sort | balancing act the complex role of nk cells in immune regulation |
| topic | NK cell adaptive immunity regulation T cell B cell virus infection |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1275028/full |
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