Imaging Inflammation in Patients and Animals: Focus on PET Imaging the Vulnerable Plaque
Acute coronary syndrome (ACS) describes a range of conditions associated with the rupture of high-risk or vulnerable plaque. Vulnerable atherosclerotic plaque is associated with many changes in its microenvironment which could potentially cause rapid plaque progression. Present-day PET imaging prese...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/10/2573 |
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| author | Benjamin Bartlett Herbert P. Ludewick Silvia Lee Shipra Verma Roslyn J. Francis Girish Dwivedi |
| author_facet | Benjamin Bartlett Herbert P. Ludewick Silvia Lee Shipra Verma Roslyn J. Francis Girish Dwivedi |
| author_sort | Benjamin Bartlett |
| collection | DOAJ |
| description | Acute coronary syndrome (ACS) describes a range of conditions associated with the rupture of high-risk or vulnerable plaque. Vulnerable atherosclerotic plaque is associated with many changes in its microenvironment which could potentially cause rapid plaque progression. Present-day PET imaging presents a plethora of radiopharmaceuticals designed to image different characteristics throughout plaque progression. Improved knowledge of atherosclerotic disease pathways has facilitated a growing number of pathophysiological targets for more innovative radiotracer design aimed at identifying at-risk vulnerable plaque and earlier intervention opportunity. This paper reviews the efficacy of PET imaging radiotracers <sup>18</sup>F-FDG, <sup>18</sup>F-NaF, <sup>68</sup>Ga-DOTATATE, <sup>64</sup>Cu-DOTATATE and <sup>68</sup>Ga-pentixafor in plaque characterisation and risk assessment, as well as the translational potential of novel radiotracers in animal studies. Finally, we discuss our murine PET imaging experience and the challenges encountered. |
| first_indexed | 2024-03-10T06:39:59Z |
| format | Article |
| id | doaj.art-e76d4b8b6f8f4e42931ff4c117091656 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T06:39:59Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e76d4b8b6f8f4e42931ff4c1170916562023-11-22T17:45:47ZengMDPI AGCells2073-44092021-09-011010257310.3390/cells10102573Imaging Inflammation in Patients and Animals: Focus on PET Imaging the Vulnerable PlaqueBenjamin Bartlett0Herbert P. Ludewick1Silvia Lee2Shipra Verma3Roslyn J. Francis4Girish Dwivedi5Department of Advanced Clinical and Translational Cardiovascular Imaging, Harry Perkins Institute of Medical Research, Murdoch, WA 6150, AustraliaDepartment of Advanced Clinical and Translational Cardiovascular Imaging, Harry Perkins Institute of Medical Research, Murdoch, WA 6150, AustraliaDepartment of Advanced Clinical and Translational Cardiovascular Imaging, Harry Perkins Institute of Medical Research, Murdoch, WA 6150, AustraliaDepartment of Nuclear Medicine, PET CT and Radionuclide Therapy, Fiona Stanley Hospital, Murdoch, WA 6150, AustraliaSchool of Medicine, University of Western Australia, Perth, WA 6009, AustraliaDepartment of Advanced Clinical and Translational Cardiovascular Imaging, Harry Perkins Institute of Medical Research, Murdoch, WA 6150, AustraliaAcute coronary syndrome (ACS) describes a range of conditions associated with the rupture of high-risk or vulnerable plaque. Vulnerable atherosclerotic plaque is associated with many changes in its microenvironment which could potentially cause rapid plaque progression. Present-day PET imaging presents a plethora of radiopharmaceuticals designed to image different characteristics throughout plaque progression. Improved knowledge of atherosclerotic disease pathways has facilitated a growing number of pathophysiological targets for more innovative radiotracer design aimed at identifying at-risk vulnerable plaque and earlier intervention opportunity. This paper reviews the efficacy of PET imaging radiotracers <sup>18</sup>F-FDG, <sup>18</sup>F-NaF, <sup>68</sup>Ga-DOTATATE, <sup>64</sup>Cu-DOTATATE and <sup>68</sup>Ga-pentixafor in plaque characterisation and risk assessment, as well as the translational potential of novel radiotracers in animal studies. Finally, we discuss our murine PET imaging experience and the challenges encountered.https://www.mdpi.com/2073-4409/10/10/2573PET imagingatherosclerosisvulnerable plaqueinflammation |
| spellingShingle | Benjamin Bartlett Herbert P. Ludewick Silvia Lee Shipra Verma Roslyn J. Francis Girish Dwivedi Imaging Inflammation in Patients and Animals: Focus on PET Imaging the Vulnerable Plaque Cells PET imaging atherosclerosis vulnerable plaque inflammation |
| title | Imaging Inflammation in Patients and Animals: Focus on PET Imaging the Vulnerable Plaque |
| title_full | Imaging Inflammation in Patients and Animals: Focus on PET Imaging the Vulnerable Plaque |
| title_fullStr | Imaging Inflammation in Patients and Animals: Focus on PET Imaging the Vulnerable Plaque |
| title_full_unstemmed | Imaging Inflammation in Patients and Animals: Focus on PET Imaging the Vulnerable Plaque |
| title_short | Imaging Inflammation in Patients and Animals: Focus on PET Imaging the Vulnerable Plaque |
| title_sort | imaging inflammation in patients and animals focus on pet imaging the vulnerable plaque |
| topic | PET imaging atherosclerosis vulnerable plaque inflammation |
| url | https://www.mdpi.com/2073-4409/10/10/2573 |
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