Autosomal recessive hyposegmentation of granulocytes in Australian Shepherd Dogs indicates a role for LMBR1L in myeloid leukocytes.

Autosomal recessive hyposegmentation of granulocytes in Australian Shepherd Dogs indicates a role for LMBR1L in myeloid leukocytes.

Pelger-Huët anomaly (PHA) in humans is an autosomal dominant hematological phenotype without major clinical consequences. PHA involves a characteristic hyposegmentation of granulocytes (HG). Human PHA is caused by heterozygous loss of function variants in the LBR gene encoding lamin receptor B. Bi-a...

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Bibliographic Details
Main Authors: Bianca Lourdes Frehner, Matthias Christen, Iris M Reichler, Vidhya Jagannathan, Marilisa Novacco, Barbara Riond, Laureen M Peters, José Suárez Sánchez-Andrade, Aldona Pieńkowska-Schelling, Claude Schelling, Anja Kipar, Tosso Leeb, Orsolya Balogh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-06-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010805

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https://doi.org/10.1371/journal.pgen.1010805

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