Correlation between serum ANGPTL4 levels and white matter hyperintensity and cognitive impairment in patients with cerebral small vessel disease
Abstract Objectives To investigate the correlation between serum angiopoietin‐like protein 4 (ANGPTL4) levels, white matter hyperintensity (WMH), and cognitive impairment (CI) in patients with cerebral small vessel disease (CSVD). Methods This cross‐sectional study enrolled 171 patients with CSVD wh...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.3401 |
| _version_ | 1797293132242485248 |
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| author | Jianhua Zhao Shiyun Zhang Xiaoting Wang Minghua Wang Zehua Wang Ruotai Li Yuxi Liu Chengbiao Lu Shaomin Li |
| author_facet | Jianhua Zhao Shiyun Zhang Xiaoting Wang Minghua Wang Zehua Wang Ruotai Li Yuxi Liu Chengbiao Lu Shaomin Li |
| author_sort | Jianhua Zhao |
| collection | DOAJ |
| description | Abstract Objectives To investigate the correlation between serum angiopoietin‐like protein 4 (ANGPTL4) levels, white matter hyperintensity (WMH), and cognitive impairment (CI) in patients with cerebral small vessel disease (CSVD). Methods This cross‐sectional study enrolled 171 patients with CSVD who attended the First Affiliated Hospital of Xinxiang Medical University from December 2021 to July 2022. All subjects underwent a 3.0T head magnetic resonance imaging, neuropsychology assessment, and blood sampling. Serum ANGPTL4 levels were detected by enzyme‐linked immunosorbent assay and the severity of WMH was assessed by the Fazekas scale. According to the Montreal Cognitive Assessment (MoCA) scale, subjects were divided into normal cognition group (NC, n = 80) and CI group (n = 91). According to the total Fazekas scores, subjects were divided into a mild WMH group (n = 84), a moderate WMH group (n = 70), and a severe WMH group (n = 17). Results Serum ANGPTL4 levels were significantly higher in the CI group than in the NC group (p < .05) and were negatively correlated with mini–mental state examination scores and MoCA scores (r = −0.26, −0.341, p < .05). Serum ANGPTL4 levels increased significantly in the mild to moderate WMH group but tended to decrease in the severe WMH group. Binary logistic regression analysis showed that ANGPTL4 was an independent influencing factor for CSVD‐CI (OR = 2.062, 95% CI (1.591–2.674), p < .001). The area under curve of ANGPTL4 for CSVD‐CI was 0.847 (0.791–0.903). Conclusion ANGPTL4 may be involved in the process of white matter damage and CI in CSVD patients and shows a diagnostic value for CSVD‐CI. |
| first_indexed | 2024-03-07T20:08:28Z |
| format | Article |
| id | doaj.art-e76fe63642264c60863ade26a28d1184 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-07T20:08:28Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-e76fe63642264c60863ade26a28d11842024-02-28T03:46:31ZengWileyBrain and Behavior2162-32792024-02-01142n/an/a10.1002/brb3.3401Correlation between serum ANGPTL4 levels and white matter hyperintensity and cognitive impairment in patients with cerebral small vessel diseaseJianhua Zhao0Shiyun Zhang1Xiaoting Wang2Minghua Wang3Zehua Wang4Ruotai Li5Yuxi Liu6Chengbiao Lu7Shaomin Li8Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, Department of NeurologyFirst Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenanChinaHenan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, Department of NeurologyFirst Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenanChinaHenan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, Department of NeurologyFirst Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenanChinaDepartment of Neurology Beijing Tiantan Hospital, Capital Medical University Beijing ChinaHenan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, Department of NeurologyFirst Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenanChinaHenan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, Department of NeurologyFirst Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenanChinaHenan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, Department of NeurologyFirst Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenanChinaHenan International Joint Laboratory of Non‐Invasive Neuromodulation, Department of Physiology and NeurobiologyXinxiang Medical UniversityXinxiangHenanChinaAnn Romney Center for Neurologic Diseases, Brigham and Women's HospitalHarvard Medical SchoolBostonMassachusettsUSAAbstract Objectives To investigate the correlation between serum angiopoietin‐like protein 4 (ANGPTL4) levels, white matter hyperintensity (WMH), and cognitive impairment (CI) in patients with cerebral small vessel disease (CSVD). Methods This cross‐sectional study enrolled 171 patients with CSVD who attended the First Affiliated Hospital of Xinxiang Medical University from December 2021 to July 2022. All subjects underwent a 3.0T head magnetic resonance imaging, neuropsychology assessment, and blood sampling. Serum ANGPTL4 levels were detected by enzyme‐linked immunosorbent assay and the severity of WMH was assessed by the Fazekas scale. According to the Montreal Cognitive Assessment (MoCA) scale, subjects were divided into normal cognition group (NC, n = 80) and CI group (n = 91). According to the total Fazekas scores, subjects were divided into a mild WMH group (n = 84), a moderate WMH group (n = 70), and a severe WMH group (n = 17). Results Serum ANGPTL4 levels were significantly higher in the CI group than in the NC group (p < .05) and were negatively correlated with mini–mental state examination scores and MoCA scores (r = −0.26, −0.341, p < .05). Serum ANGPTL4 levels increased significantly in the mild to moderate WMH group but tended to decrease in the severe WMH group. Binary logistic regression analysis showed that ANGPTL4 was an independent influencing factor for CSVD‐CI (OR = 2.062, 95% CI (1.591–2.674), p < .001). The area under curve of ANGPTL4 for CSVD‐CI was 0.847 (0.791–0.903). Conclusion ANGPTL4 may be involved in the process of white matter damage and CI in CSVD patients and shows a diagnostic value for CSVD‐CI.https://doi.org/10.1002/brb3.3401ANGPTL4cerebral small vessel diseasecognitive impairmentwhite matter hyperintensity |
| spellingShingle | Jianhua Zhao Shiyun Zhang Xiaoting Wang Minghua Wang Zehua Wang Ruotai Li Yuxi Liu Chengbiao Lu Shaomin Li Correlation between serum ANGPTL4 levels and white matter hyperintensity and cognitive impairment in patients with cerebral small vessel disease Brain and Behavior ANGPTL4 cerebral small vessel disease cognitive impairment white matter hyperintensity |
| title | Correlation between serum ANGPTL4 levels and white matter hyperintensity and cognitive impairment in patients with cerebral small vessel disease |
| title_full | Correlation between serum ANGPTL4 levels and white matter hyperintensity and cognitive impairment in patients with cerebral small vessel disease |
| title_fullStr | Correlation between serum ANGPTL4 levels and white matter hyperintensity and cognitive impairment in patients with cerebral small vessel disease |
| title_full_unstemmed | Correlation between serum ANGPTL4 levels and white matter hyperintensity and cognitive impairment in patients with cerebral small vessel disease |
| title_short | Correlation between serum ANGPTL4 levels and white matter hyperintensity and cognitive impairment in patients with cerebral small vessel disease |
| title_sort | correlation between serum angptl4 levels and white matter hyperintensity and cognitive impairment in patients with cerebral small vessel disease |
| topic | ANGPTL4 cerebral small vessel disease cognitive impairment white matter hyperintensity |
| url | https://doi.org/10.1002/brb3.3401 |
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