Regulation of flagellar motility and biosynthesis in enterohemorrhagic Escherichia coli O157:H7
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a human pathogen that causes a variety of diseases, such as hemorrhagic colitis and lethal hemolytic uremic syndrome. Flagellum-dependent motility plays diverse roles in the pathogenesis of EHEC O157:H7, including its migration to an optimal host...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2022.2110822 |
| _version_ | 1811215176284766208 |
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| author | Hongmin Sun Min Wang Yutao Liu Pan Wu Ting Yao Wen Yang Qian Yang Jun Yan Bin Yang |
| author_facet | Hongmin Sun Min Wang Yutao Liu Pan Wu Ting Yao Wen Yang Qian Yang Jun Yan Bin Yang |
| author_sort | Hongmin Sun |
| collection | DOAJ |
| description | Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a human pathogen that causes a variety of diseases, such as hemorrhagic colitis and lethal hemolytic uremic syndrome. Flagellum-dependent motility plays diverse roles in the pathogenesis of EHEC O157:H7, including its migration to an optimal host site, adherence and colonization, survival at the infection site, and post-infection dispersal. However, it is very expensive for cellular economy in terms of the number of genes and the energy required for flagellar biosynthesis and functioning. Furthermore, the flagellar filament bears strong antigenic properties that induce a strong host immune response. Consequently, the flagellar gene expression and biosynthesis are highly regulated to occur at the appropriate time and place by different regulatory influences. The present review focuses on the regulatory mechanisms of EHEC O157:H7 motility and flagellar biosynthesis, especially in terms of flagellar gene regulation by environmental factors, regulatory proteins, and small regulatory RNAs. |
| first_indexed | 2024-04-12T06:17:39Z |
| format | Article |
| id | doaj.art-e771795597474326b0072c351fa9131a |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-12T06:17:39Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-e771795597474326b0072c351fa9131a2022-12-22T03:44:25ZengTaylor & Francis GroupGut Microbes1949-09761949-09842022-12-0114110.1080/19490976.2022.2110822Regulation of flagellar motility and biosynthesis in enterohemorrhagic Escherichia coli O157:H7Hongmin Sun0Min Wang1Yutao Liu2Pan Wu3Ting Yao4Wen Yang5Qian Yang6Jun Yan7Bin Yang8TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, ChinaTEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, ChinaTEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, ChinaTEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, ChinaTEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, ChinaTEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, ChinaTEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, ChinaTEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, ChinaTEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, ChinaEnterohemorrhagic Escherichia coli (EHEC) O157:H7 is a human pathogen that causes a variety of diseases, such as hemorrhagic colitis and lethal hemolytic uremic syndrome. Flagellum-dependent motility plays diverse roles in the pathogenesis of EHEC O157:H7, including its migration to an optimal host site, adherence and colonization, survival at the infection site, and post-infection dispersal. However, it is very expensive for cellular economy in terms of the number of genes and the energy required for flagellar biosynthesis and functioning. Furthermore, the flagellar filament bears strong antigenic properties that induce a strong host immune response. Consequently, the flagellar gene expression and biosynthesis are highly regulated to occur at the appropriate time and place by different regulatory influences. The present review focuses on the regulatory mechanisms of EHEC O157:H7 motility and flagellar biosynthesis, especially in terms of flagellar gene regulation by environmental factors, regulatory proteins, and small regulatory RNAs.https://www.tandfonline.com/doi/10.1080/19490976.2022.2110822EHEC O157:H7flagellum-mediated motilityflagellar biosynthesisflagellar gene expressionregulationmolecular mechanism |
| spellingShingle | Hongmin Sun Min Wang Yutao Liu Pan Wu Ting Yao Wen Yang Qian Yang Jun Yan Bin Yang Regulation of flagellar motility and biosynthesis in enterohemorrhagic Escherichia coli O157:H7 Gut Microbes EHEC O157:H7 flagellum-mediated motility flagellar biosynthesis flagellar gene expression regulation molecular mechanism |
| title | Regulation of flagellar motility and biosynthesis in enterohemorrhagic Escherichia coli O157:H7 |
| title_full | Regulation of flagellar motility and biosynthesis in enterohemorrhagic Escherichia coli O157:H7 |
| title_fullStr | Regulation of flagellar motility and biosynthesis in enterohemorrhagic Escherichia coli O157:H7 |
| title_full_unstemmed | Regulation of flagellar motility and biosynthesis in enterohemorrhagic Escherichia coli O157:H7 |
| title_short | Regulation of flagellar motility and biosynthesis in enterohemorrhagic Escherichia coli O157:H7 |
| title_sort | regulation of flagellar motility and biosynthesis in enterohemorrhagic escherichia coli o157 h7 |
| topic | EHEC O157:H7 flagellum-mediated motility flagellar biosynthesis flagellar gene expression regulation molecular mechanism |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2022.2110822 |
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