Nicotine: From Discovery to Biological Effects
Nicotine, the primary psychoactive agent in tobacco leaves, has led to the widespread use of tobacco, with over one billion smokers globally. This article provides a historical overview of tobacco and discusses tobacco dependence, as well as the biological effects induced by nicotine on mammalian ce...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/19/14570 |
| _version_ | 1797575854444773376 |
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| author | Luigi Sansone Francesca Milani Riccardo Fabrizi Manuel Belli Mario Cristina Vincenzo Zagà Antonio de Iure Luca Cicconi Stefano Bonassi Patrizia Russo |
| author_facet | Luigi Sansone Francesca Milani Riccardo Fabrizi Manuel Belli Mario Cristina Vincenzo Zagà Antonio de Iure Luca Cicconi Stefano Bonassi Patrizia Russo |
| author_sort | Luigi Sansone |
| collection | DOAJ |
| description | Nicotine, the primary psychoactive agent in tobacco leaves, has led to the widespread use of tobacco, with over one billion smokers globally. This article provides a historical overview of tobacco and discusses tobacco dependence, as well as the biological effects induced by nicotine on mammalian cells. Nicotine induces various biological effects, such as neoangiogenesis, cell division, and proliferation, and it affects neural and non-neural cells through specific pathways downstream of nicotinic receptors (nAChRs). Specific effects mediated by α7 nAChRs are highlighted. Nicotine is highly addictive and hazardous. Public health initiatives should prioritize combating smoking and its associated risks. Understanding nicotine’s complex biological effects is essential for comprehensive research and informed health policies. While potential links between nicotine and COVID-19 severity warrant further investigation, smoking remains a significant cause of morbidity and mortality globally. Effective public health strategies are vital to promote healthier lifestyles. |
| first_indexed | 2024-03-10T21:44:11Z |
| format | Article |
| id | doaj.art-e7727f528fed46518a4ad3f8c6dea169 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:44:11Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e7727f528fed46518a4ad3f8c6dea1692023-11-19T14:28:32ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124191457010.3390/ijms241914570Nicotine: From Discovery to Biological EffectsLuigi Sansone0Francesca Milani1Riccardo Fabrizi2Manuel Belli3Mario Cristina4Vincenzo Zagà5Antonio de Iure6Luca Cicconi7Stefano Bonassi8Patrizia Russo9Department of Human Sciences and Quality, Life Promotion San Raffaele University, Via di Val Cannuta 247, 00166 Rome, ItalyClinical and Molecular Epidemiology, IRCCS San Raffaele Roma, Via di Val Cannuta 247, 00166 Rome, ItalyClinical and Molecular Epidemiology, IRCCS San Raffaele Roma, Via di Val Cannuta 247, 00166 Rome, ItalyDepartment of Human Sciences and Quality, Life Promotion San Raffaele University, Via di Val Cannuta 247, 00166 Rome, ItalyDepartment of Human Sciences and Quality, Life Promotion San Raffaele University, Via di Val Cannuta 247, 00166 Rome, ItalyItalian Society of Tabaccology (SITAB), 00136 Bologna, ItalyDepartment of Human Sciences and Quality, Life Promotion San Raffaele University, Via di Val Cannuta 247, 00166 Rome, ItalyClinical and Molecular Epidemiology, IRCCS San Raffaele Roma, Via di Val Cannuta 247, 00166 Rome, ItalyDepartment of Human Sciences and Quality, Life Promotion San Raffaele University, Via di Val Cannuta 247, 00166 Rome, ItalyDepartment of Human Sciences and Quality, Life Promotion San Raffaele University, Via di Val Cannuta 247, 00166 Rome, ItalyNicotine, the primary psychoactive agent in tobacco leaves, has led to the widespread use of tobacco, with over one billion smokers globally. This article provides a historical overview of tobacco and discusses tobacco dependence, as well as the biological effects induced by nicotine on mammalian cells. Nicotine induces various biological effects, such as neoangiogenesis, cell division, and proliferation, and it affects neural and non-neural cells through specific pathways downstream of nicotinic receptors (nAChRs). Specific effects mediated by α7 nAChRs are highlighted. Nicotine is highly addictive and hazardous. Public health initiatives should prioritize combating smoking and its associated risks. Understanding nicotine’s complex biological effects is essential for comprehensive research and informed health policies. While potential links between nicotine and COVID-19 severity warrant further investigation, smoking remains a significant cause of morbidity and mortality globally. Effective public health strategies are vital to promote healthier lifestyles.https://www.mdpi.com/1422-0067/24/19/14570nicotinenicotinic receptortobaccodependencecell proliferationneo-angiogenesis |
| spellingShingle | Luigi Sansone Francesca Milani Riccardo Fabrizi Manuel Belli Mario Cristina Vincenzo Zagà Antonio de Iure Luca Cicconi Stefano Bonassi Patrizia Russo Nicotine: From Discovery to Biological Effects International Journal of Molecular Sciences nicotine nicotinic receptor tobacco dependence cell proliferation neo-angiogenesis |
| title | Nicotine: From Discovery to Biological Effects |
| title_full | Nicotine: From Discovery to Biological Effects |
| title_fullStr | Nicotine: From Discovery to Biological Effects |
| title_full_unstemmed | Nicotine: From Discovery to Biological Effects |
| title_short | Nicotine: From Discovery to Biological Effects |
| title_sort | nicotine from discovery to biological effects |
| topic | nicotine nicotinic receptor tobacco dependence cell proliferation neo-angiogenesis |
| url | https://www.mdpi.com/1422-0067/24/19/14570 |
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